Phosphatase Subfamily PXYLP1
From PhosphataseWiki
Phosphatase Classification: Fold HP: Superfamily HP: Family HP, branch 2: Subfamily PXYLP1
Evolution
PXYLP1 is found in bilateria, but Entamoeba histolytica and Emiliania huxleyi have PXYLP1 like genes.
Domain
PXYLP1 has a N-terminal transmembrane region and C-terminal phosphatase domain.
Functions
Human PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans . In collaboration with kinase FAM20B, it regulates the transient phosphorylation of the Xyl residue in the glycosaminoglycan-protein linkage region, which controls the formation of glycosaminoglycan chains of proteoglycans [1].
