Phosphatase Subfamily PPP4C Functions
Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PPPc: Subfamily PPP4C (catalytic subunit of PP4 holoenzyme) - Functions notes
PP4 negatively regulates type I IFN Production and antiviral innate immunity by dephosphorylating and deactivating TANK-binding kinase 1 (TBK1) of TK group, ACK family according to KinBase classification [1].
PPP4C is implicated in cancer. For instance, high expression of PPP4C is associated with the aggressive malignant behavior of colorectal carcinoma [2].
PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX.
PP4 in C. elegans is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene [3].
References
- Zhan Z, Cao H, Xie X, Yang L, Zhang P, Chen Y, Fan H, Liu Z, and Liu X. Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1. J Immunol. 2015 Oct 15;195(8):3849-57. DOI:10.4049/jimmunol.1403083 |
- Li X, Liang L, Huang L, Ma X, Li D, and Cai S. High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. Mol Cancer. 2015 Apr 28;14:95. DOI:10.1186/s12943-015-0356-7 |
- Sato-Carlton A, Li X, Crawley O, Testori S, Martinez-Perez E, Sugimoto A, and Carlton PM. Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age. PLoS Genet. 2014 Oct;10(10):e1004638. DOI:10.1371/journal.pgen.1004638 |
- Chen MY, Chen YP, Wu MS, Yu GY, Lin WJ, Tan TH, and Su YW. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One. 2014;9(9):e107505. DOI:10.1371/journal.pone.0107505 |
