Phosphatase Subfamily DSP11

Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP11

DSP11 is a metazoan-specific subfamily. Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing.

Evolution

DSP11 subfamily is found through metazoa (unpublished data from gOrtholog).

Domain

DSP11 has a single domain: phosphatase domain.

Function

Human DUSP11 is mainly localized to the cell nucleus. It was originally identified as being associated with RNA or ribonucleoprotein complexes. It is therefore called phosphatase that interacts with RNA–ribonucleoprotein complex 1 (PIR1). Its exact physiological substrate is unknown, but several lines of evidence link this phosphatase to RNA splicing [1]. DSP11 prefers to dephosphorylate RNA than phosphoprotein substrates. Its primary function in vivo is supposed to dephosphorylate RNA 5′-ends [2]. This is not surprising given that it is close to another atypical DSP, RNGTT, (RNA guanylyltransferase and 5'-phosphatase). Its function was reviewed in introduction of [1] in details.

References

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