Phosphatase Subfamily PTPDC1

Phosphatase Classification: Superfamily CC1: Family DSP: Subfamily PTPDC1

Evolution

PTPDC1 is found in holozoans but lost from Drosophila and most other insects. Distant homologs are also seen in a number of protist genomes.

Domain Structure

PTPDC1 typically has an N-terminal phosphatase domain and usually an extended C-terminal region. The Monosiga homolog has an N-terminal PH domain extension.

Functions

Mouse PTPDC1 has been proposed as a cilia gene by tissue-specific expression [1] and RNAi knockdown [2] and implicated in centriole duplication and cytokinesis [3]

References

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