Phosphatase Subfamily PPM1E

Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E

The subfamily is named named after two human PPMs, PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N) and PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g [1, 2, 3] and PAK [4], and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).

The subfamily has some potent inhibitors [5].

References

1. Takeuchi M, Ishida A, Kameshita I, Kitani T, Okuno S, and Fujisawa H. Identification and characterization of CaMKP-N, nuclear calmodulin-dependent protein kinase phosphatase. J Biochem. 2001 Dec;130(6):833-40. DOI:10.1093/oxfordjournals.jbchem.a003055 |
2. Takeuchi M, Taniguchi T, and Fujisawa H. Identification and characterization of nuclear localization signals of CaMKP-N. J Biochem. 2004 Aug;136(2):183-8. DOI:10.1093/jb/mvh109 |
3. Ishida A, Tada Y, Nimura T, Sueyoshi N, Katoh T, Takeuchi M, Fujisawa H, Taniguchi T, and Kameshita I. Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction. Arch Biochem Biophys. 2005 Mar 1;435(1):134-46. DOI:10.1016/j.abb.2004.11.022 |
4. Koh CG, Tan EJ, Manser E, and Lim L. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr Biol. 2002 Feb 19;12(4):317-21. DOI:10.1016/s0960-9822(02)00652-8 |
5. Sueyoshi N, Takao T, Nimura T, Sugiyama Y, Numano T, Shigeri Y, Taniguchi T, Kameshita I, and Ishida A. Inhibitors of the Ca(2+)/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N). Biochem Biophys Res Commun. 2007 Nov 23;363(3):715-21. DOI:10.1016/j.bbrc.2007.09.022 |