Phosphatase Gene PPM1E

Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E: Gene PPM1E

PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N).

PPM1E and another phosphatase of this subfamily PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase) dephosphorylate and regulate multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs). PPM1E dephosphorylates CaMKIV and nuclear CaMKII, whereas PPM1F dephosphorylates CaMKI and cytosolic CaMKII. their localizations are different [1]. PPM1E is localized in the nucleus, whereas PPM1F is localized in the cytosol. PPM1E contains two NLSs, NLS1 and NLS2, at the C-terminus. A cluster of basic residues in the NLSs is important for their function. NLS1 and NLS2 function independently, but mutagenesis analysis suggests that these NLSs interact with each other [2].

PPM1E and PPM1F also dephoshorylate p21 (Cdc42/Rac)- activated kinase PAK [3].

PPM1E and PPM1F also dephosphorylate 5'-AMP-activated protein kinase (AMPK) [4]. The activation of AMPK is related to the treatment of type 2 diabetes.

References

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