Phosphatase Subfamily PPM1E

Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E

The subfamily is named named after two human PPMs, PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N) and PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g [1, 2, 3] and PAK [4], and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).

The subfamily has some potent inhibitors [5].

The subfamily also dephosphorylate 5'-AMP-activated protein kinase (AMPK) [6]. The activation of AMPK is related to the treatment of type 2 diabetes.

References

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