Phosphatase Subfamily FCP1

Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily FCP1

F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1 (CTDP1), prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].

Evolution

FCP1 is conserved from yeast to human, usually one copy per genome.

Domain Structure

In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region (FCP1_C) that binds regulatory TFIIF.

The FCP1_C domain is found widely in deuterosomes (from sea urchin to chordates). It is absent from most proteostomes, except some individual organisms. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.

Functions

FCP1 preferentially hydrolyzes Ser2 in CTD repeats in budding yeast [1] and fission yeast [2].

Substrates and Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

References

Error fetching PMID 24752900:
Error fetching PMID 15304220:
Error fetching PMID 25883047:

Links

Human FCP1 from NCBI Gene

Technical notes

FCP1_C domain

In order to find FCP1_C domain phylogenetic distribution among FCP1, we obtained the FCP1 from our internal orthology database, which contains 227 from 183 eukaryotic genomes. We then searched the FCP1_C domain by Pfam web server.