Phosphatase Subfamily PPP4C Functions
Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PPPc: Subfamily PPP4C (catalytic subunit of PP4 holoenzyme) - Functions notes
PP4 negatively regulates type I IFN Production and antiviral innate immunity by dephosphorylating and deactivating TANK-binding kinase 1 (TBK1) of TK group, ACK family according to KinBase classification [1].
PPP4C is implicated in cancer. For instance, high expression of PPP4C is associated with the aggressive malignant behavior of colorectal carcinoma [2].
PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX.
PP4 in C. elegans is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene [3].
References
Error fetching PMID 25927939:
Error fetching PMID 25340746:
Error fetching PMID 26363053:
- Error fetching PMID 26363053:
- Error fetching PMID 25927939:
- Error fetching PMID 25340746:
- Error fetching PMID 25215539:
