Phosphatase Subfamily CG42327
Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily CG42327
CG42327 is a receptor PTP found in metazoa, of unknown function and distribution.
Evolution
CG42327 is defined by the Drosophila melanogaster CG42327 gene. Clear orthologs exist in most arthropods. Possible orthologs exist in several other metazoa, including Amphimedon (AquePTP-Un-2), Monosiga (MbrePTP-Un-8) and S. purpuratus (SpurPTP-Un-2). The Amphimedon protein also encodes a signal peptide.
Domain Structure
Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain.
The putative Monosiga homolog (MbrePTP-Un-8) has a Sec14 upstream of the phosphatase domain, but this is not conserved in choanoflagellate orthologs. It also has a C-terminal PDZ domain which is conserved in both Monosiga ovata and S. rosetta.
Functions
Unknown
References
- Chang C, Yu TW, Bargmann CI, and Tessier-Lavigne M. Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science. 2004 Jul 2;305(5680):103-6. DOI:10.1126/science.1096983 |
- Kokel M, Borland CZ, DeLong L, Horvitz HR, and Stern MJ. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 1998 May 15;12(10):1425-37. DOI:10.1101/gad.12.10.1425 |
- Marlo JE and Desai CJ. Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects. J Cell Biochem. 2006 Aug 1;98(5):1296-307. DOI:10.1002/jcb.20862 |
- Song JK, Giniger E, and Desai CJ. The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech Dev. 2008 Mar-Apr;125(3-4):247-56. DOI:10.1016/j.mod.2007.11.005 |
