Phosphatome Computational Tools and Resources
From PhosphataseWiki
PTP.cshl
PTP.cshl focuses on protein tyrosine phosphatases. It was launched in 2011 and provided a most complete census on human protein tyrosine phosphatases [1]. However, the content of the web site seems not updated since 2005.
PTP-central
PTP-central focuses on protein tyrosine phosphatases. It uses the same classification schema as the landmark work of Alonso et al. [2]. It comes with a tool (Y-Phosphatomer) to scan protein tyrosine phosphatases from genomes, and updated the total number of human protein tyrosine phosphatase to 109 [3].
GeneNet™ Phosphatase shRNA Library
GeneNet™ Phosphatase shRNA Library provides a list of 244 phosphatases, but some genes on the list are probably not phosphatases, such as discs and speedy homolog A, SIRPA and etc.
References
- Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, Jansen PG, Andersen HS, Tonks NK, and Møller NP. Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol. 2001 Nov;21(21):7117-36. DOI:10.1128/MCB.21.21.7117-7136.2001 |
- Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, and Mustelin T. Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11;117(6):699-711. DOI:10.1016/j.cell.2004.05.018 |
- Hatzihristidis T, Liu S, Pryszcz L, Hutchins AP, Gabaldón T, Tremblay ML, and Miranda-Saavedra D. PTP-central: a comprehensive resource of protein tyrosine phosphatases in eukaryotic genomes. Methods. 2014 Jan 15;65(2):156-64. DOI:10.1016/j.ymeth.2013.07.031 |
