Phosphatase Superfamily Cys-based III

Phosphatase Classification: Superfamily Cys-based III

The superfamily consists of two member families present in human low molecular weight PTP (LWMPTP) and SSU72. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) [1].

The subfamily has an additional member only present in prokaryotes, arsenate reductase (ArsC). It has low sequence identity with LMWPTP and SSU72, 19% between Golden Staph ArsC (PDB ID: 1LJL) and mouse LMWPTP (PDB ID: 2P4U), 16% between Golden Staph ArsC and fruit fly SSU72 (PDB ID: 3FMV). But, ArsC has very similar structure with LMWPTP as shown in [SCOP database].

Reference

1. Zhang Y, Zhang M, and Zhang Y. Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem J. 2011 Mar 15;434(3):435-44. DOI:10.1042/BJ20101471 |