Phosphatase Subfamily FCP1

Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily FCP1

F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].

Evolution

FCP1 is conserved from yeast to human, usually one copy per genome.

Domain Structure

In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF.

Substrates and Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

References

1. Kamenski T, Heilmeier S, Meinhart A, and Cramer P. Structure and mechanism of RNA polymerase II CTD phosphatases. Mol Cell. 2004 Aug 13;15(3):399-407. DOI:10.1016/j.molcel.2004.06.035 |

Links

Human FCP1 from NCBI Gene