Phosphatase Family PAP
From PhosphataseWiki
Phosphatase Classification: Fold MTDP: Superfamily MTDP: Family PAP (purple acid phosphatase)
PAP is short for purple acid phosphatase. It has two subfamilies present in human:
- ACP5. ACP5 subfamily is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acid pH in vitro. It also show phosphatase activity towards protein osteopontin, and mannose 6-phosphate modification on lysosomal proteins.
- PAPL. PAPL is conserved holozoan, but is lost in most of arthropoda. Its function is unclear.
