Phosphatase Subfamily DSP8

Phosphatase Classification: Superfamily CC1: Family DSP: Subfamily DSP8

Evolution

DSP8 is found in metazoan, typically single-copy, but expanded to two genes, DUSP8 and DUSP16 in human.

Domain Structure

TBD.

Functions

DUSP16 (MKP7)

DUSP16 is predominantly localized in the cytoplasm when expressed in cultured cells, whereas DUSP8 (hVH5) is both in the nucleus and the cytoplasm. DUSP16 binds to and inactivates p38 MAPK and JNK/SAPK, but not ERK. In particular, DUSP16 binds to and inactivates p38 alpha and -beta isoforms, but not gamma or delta [1].