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Welcome to Phosphatase Wiki, a resource for of phosphatases and phosphatase signaling. This is a pilot project for sharing and publication of discoveries that do not fit into traditional publications or haven't yet been polished for publication. Initial content is mostly from the Manning lab at Salk (moved to Genentech in 2012), but we welcome anyone who would like to contribute. Like other wiki's, just go to the login page to request an account.

Protein phosphatase classification

Of the hundreds of phosphatases in the genome, how are they organized and classified?

Topics

Dephosphorylation on unusual amino acids

Unusual evidence for phosphorylation on histidine, aspartate, cysteine, lysine, and arginine.

Regulatory subunits

Some phosphatases, particularly PPPs, consist of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.

Phosphorylation of RNA polymerase II C-terminal domain

The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. This complex phosphorylation patterns are regulated by quite a few phosphatases and kinases.

PTPLA is a dubious phosphatase

Notes on the PTPLA/PTP-like family that was claimed to be a phosphatase, but probably is not.