Phosphatase Subfamily Acr2

Phosphatase Classification: Superfamily Cys-based II: Family CDC25: Subfamily Acr2

Arsenate Reductase

Prokaryotes and eukaryotes use arsenate reductases of distinct folds. E. coli uses ArsC, which belongs to Superfamily Cys-based III, the same as LMWPTP and SSU72. In eukaryotes, particularly fungi, plants and protists, ACR2 exhibit arsenate reductase activity [1]

Arc2 as Arsenate Reductase

The ACR2 gene of Saccharomyces cerevisiae overexpressed in E. coli was shown to exhibit arsenate reductase activity and complement the arsenate-sensitive phenotype of an arsC deletion in E. coli [2, 3].

Reference

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