Phosphatase Superfamily CC1

Phosphatase classification: Fold CC1: Superfamily CC1

CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of the families in human as below:

• PTP (Protein Tyrosine Phosphatase) - generally tyrosine-specific phosphatases.

• DSP (Dual Specificity Phosphatases) - diverse substrates, from tyrosine, serine, threonine to small molecules.

• PTEN - phosphoinositide phosphatases.

• Myotubularin - phosphoinositide phosphatases.

• SAC - phosphoinositide phosphatases.

• Paladin - catalytically inactive phosphatase.

Fungi, plants and many protists also have the OCA family.

CC1 shares a Cys-based catalytic motif, CX5R with another two superfamilies CC2 and CC3, but it has distinct structure from them.