Phosphatase Subfamily egg

Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Egg

Evolution

The eak subfamily is nematode specific. C. elegans has three members: egg-3, egg-4, egg-5.

Domain

The egg subfamily has a single structural domain: the phosphatase domain of CC1 fold.

Function

All three C. elegans members are predicted to be catalytically inactive, due to loss of the cysteine and/or arginine of the Cx5R motif. egg-4 and egg-5 control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling [1, 2, 3].

References

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