Other Classification Schemes

Phosphatase Classification: Other Classification Schemes

PP1 & PP2 v.s. PPP & PPM

Using enzymological criteria, PPP & PPM members were initially classified as type 1 (PP1) and type 2 (PP2). PP2 enzymes were further divided into three groups on the basis of the requirement for metal ions: PP2A (not requiring metal ions), PP2B (requiring calcium), and PP2C (requiring magnesium). Based upon their sequence and structure similarity, PP1, PP2A and PP2B form PPP, and PP2C forms PPM.