Difference between revisions of "Phosphatase Family OCA"
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| − | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_OCA|Family OCA]] | |
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| + | The OCA family is named after the five member genes in yeast (OCA1-4, OCA6 = Oxidant-induced Cell-cycle Arrest). The family is also called Plant and Fungi Atypical (PFA)-DSPs <cite>Pulido07 Pulido11</cite>. | ||
| + | |||
| + | === Evolution === | ||
| + | The OCA family is found in many eukaryotes, including fungi, plants, protists, choanoflagellates (''Monosiga''), and sponge. It is absent from most eumetazoa, but is found in several invertebrate deuterostomes (the urchin (''Strongylocentrotus purpuratus''), lancelet (''Branchiostoma floridae'')) and even an early-branching vertebrate, the ghostshark (''Callorhinchus milii'') and a few protostomes: ''Capitella teleta'', the owl limpet (''Lottia gigantea''), and the leech (''Helobdella robusta''). | ||
| + | |||
| + | === Domain === | ||
| + | OCA has a single domain, a phosphatase domain of fold CC1. | ||
| + | |||
| + | === Functions === | ||
| + | Yeast OCA members are involved in cell cycle arrest in response to oxidative damage<cite>Alic</cite>, in telomere capping <cite>lydall08</cite>, and in actin organization <cite>Care</cite>. [[Gene_OCA3|OCA3]] has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase <cite>Harashima08</cite>. | ||
| + | |||
| + | === References === | ||
| + | <biblio> | ||
| + | #Alic pmid=11408586 | ||
| + | #Care pmid=15020461 | ||
| + | #Pulido07 pmid=17976645 | ||
| + | #Pulido11 pmid=21409566 | ||
| + | #lydall08 pmid=18845848 | ||
| + | #Harashima08 pmid=18166280 | ||
| + | </biblio> | ||
Latest revision as of 20:13, 14 August 2016
Phosphatase Classification: Fold CC1: Superfamily CC1: Family OCA
The OCA family is named after the five member genes in yeast (OCA1-4, OCA6 = Oxidant-induced Cell-cycle Arrest). The family is also called Plant and Fungi Atypical (PFA)-DSPs [1, 2].
Evolution
The OCA family is found in many eukaryotes, including fungi, plants, protists, choanoflagellates (Monosiga), and sponge. It is absent from most eumetazoa, but is found in several invertebrate deuterostomes (the urchin (Strongylocentrotus purpuratus), lancelet (Branchiostoma floridae)) and even an early-branching vertebrate, the ghostshark (Callorhinchus milii) and a few protostomes: Capitella teleta, the owl limpet (Lottia gigantea), and the leech (Helobdella robusta).
Domain
OCA has a single domain, a phosphatase domain of fold CC1.
Functions
Yeast OCA members are involved in cell cycle arrest in response to oxidative damage[3], in telomere capping [4], and in actin organization [5]. OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [6].
References
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