Phosphatase Family PAP

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Phosphatase Classification: Fold MTDP:Superfamily MTDP: Family PAP (purple acid phosphatase)

PAP is short for purple acid phosphatase. It has two subfamilies present in human:

  • ACP5. ACP5 subfamily is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acid pH in vitro. It also show phosphatase activity towards protein osteopontin, and mannose 6-phosphate modification on lysosomal proteins.