Phosphatase Family PAP

Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP (purple acid phosphatase)

PAP (Purple Acid Phosphatase is found in most eukaryotes, even in some prokaryotes. It has three eukaryotic subfamilies, the first two present in human:

• ACP5. ACP5 subfamily is found in most eukaryotes. Human ACP5 hydrolyzes a variety of phosphomonoesters at acid pH in vitro. It also shows phosphatase activity towards the protein osteopontin, and the mannose 6-phosphate modification on lysosomal proteins.

• PAPL. PAPL is found in holozoa, but is lost in most arthropods. Its function is unclear.

• DCR2 subfamily is present in most fungi, most plants and some chromalveolata (internal data from gOrtholog database).