Difference between revisions of "Phosphatase Family PTEN"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily | + | __NOTOC__ |
| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTEN|Family PTEN]] | ||
| + | PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the [[Phosphatase_Family_DSP|DSP]] family. PTEN itself is found in all eukaryotes and is a negative regulator of PI3K signaling. Other defined subfamilies are largely [[holozoa]]n-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins. All subfamilies have a specialized C2 domain (C2_PTEN) immediately following the phosphatase domain. | ||
| − | + | ===== [[Phosphatase_Subfamily_PTEN|PTEN subfamily]] ===== | |
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| − | ===== [[ | + | |
PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes ([http://resdev.gene.com/gOrtholog/view/cluster/MC0001193/overview unpublished data from gOrtholog]). | PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes ([http://resdev.gene.com/gOrtholog/view/cluster/MC0001193/overview unpublished data from gOrtholog]). | ||
| − | ===== [[ | + | ===== [[Phosphatase_Subfamily_VSP|VSP subfamily]] ===== |
| − | + | The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments <cite>Iwasaki08</cite>, in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in [[holozoa]] but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication. | |
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| − | + | ===== [[Phosphatase_Subfamily_Tensin|Tensin subfamily]] ===== | |
| + | Tensin are adaptor proteins that link integrins to the actin cytoskeleton and are involved in a variety of signal transduction cascades. | ||
| + | ===== [[Phosphatase_Subfamily_Auxilin|Auxilin subfamily]] ===== | ||
| + | Inactive phosphatases that bind phospholipids during clathrin-coated vesicle formation and uncoating. Most also have a kinase domain. | ||
| − | === | + | === References === |
<biblio> | <biblio> | ||
| − | # | + | #Iwasaki08 pmid=18524949 |
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</biblio> | </biblio> | ||
Latest revision as of 18:56, 4 May 2018
Phosphatase Classification: Superfamily CC1: Family PTEN
PTEN is a family of lipid phosphatases and lipid-binding proteins that is closely related to the DSP family. PTEN itself is found in all eukaryotes and is a negative regulator of PI3K signaling. Other defined subfamilies are largely holozoan-specific and frequently appear to be catalytically inactive and to function as lipid-binding domains of larger proteins. All subfamilies have a specialized C2 domain (C2_PTEN) immediately following the phosphatase domain.
PTEN subfamily
PTEN subfamily is named after its single member in human, PTEN, which acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN is one of the most commonly lost tumor suppressors in human cancer. It is found throughout eukaryotes (unpublished data from gOrtholog).
VSP subfamily
The Voltage Sensitive Phosphatase (VSP) members consist of a voltage sensor consisting of four transmembrane segments [1], in addition to phosphatase domain and C2 domain. It has two members in human, TPTE and TPTE2 (TPIP), but TPTE is a pseudophosphatase. The subfamily is conserved in holozoa but absent from nematodes and most arthropods. It usually has a single copy in each species, and the two human copies appear to be a primate duplication.
Tensin subfamily
Tensin are adaptor proteins that link integrins to the actin cytoskeleton and are involved in a variety of signal transduction cascades.
Auxilin subfamily
Inactive phosphatases that bind phospholipids during clathrin-coated vesicle formation and uncoating. Most also have a kinase domain.
References
- Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, and Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):7970-5. DOI:10.1073/pnas.0803936105 |
