Difference between revisions of "Phosphatase Subfamily FCP1"
From PhosphataseWiki
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| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_FCP1|Subfamily FCP1]] | ||
F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast <cite>Kamenski04</cite>. | F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast <cite>Kamenski04</cite>. | ||
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In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF. | In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF. | ||
| − | === | + | ===Functions=== |
| − | + | ===== Substrates and Related Kinases ===== | |
| − | ===Substrates and Related Kinases=== | + | |
See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | ||
| − | + | === References === | |
| − | == References == | + | |
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<biblio> | <biblio> | ||
#Kamenski04 pmid=15304220 | #Kamenski04 pmid=15304220 | ||
</biblio> | </biblio> | ||
| − | + | === Links === | |
| − | ===Links=== | + | |
[http://www.ncbi.nlm.nih.gov/gene/2221 Human FCP1] from NCBI Gene | [http://www.ncbi.nlm.nih.gov/gene/2221 Human FCP1] from NCBI Gene | ||
Revision as of 18:35, 18 April 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily FCP1
F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].
Evolution
FCP1 is conserved from yeast to human, usually one copy per genome.
Domain Structure
In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF.
Functions
Substrates and Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
- Kamenski T, Heilmeier S, Meinhart A, and Cramer P. Structure and mechanism of RNA polymerase II CTD phosphatases. Mol Cell. 2004 Aug 13;15(3):399-407. DOI:10.1016/j.molcel.2004.06.035 |
Links
Human FCP1 from NCBI Gene
