Difference between revisions of "Phosphatase Subfamily PAPL"
From PhosphataseWiki
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=== Evolution === | === Evolution === | ||
| − | PAPL | + | PAPL is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL (aka ACP7, PAPL1), but many invertebrates have multiple members, including 3 members each in Monosiga, Nematostella, sponge, and sea urchin. These appear to be independent expansions by protein sequence similarity, and in sea urchin, they form a tandem duplication cluster. |
=== Domain Structure === | === Domain Structure === | ||
| − | PAPL has a phosphatase domain and | + | PAPL has a phosphatase domain and most members have an N-terminal signal peptide cleavage site. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue). |
=== Function === | === Function === | ||
Unclear. | Unclear. | ||
Revision as of 01:07, 9 May 2016
Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP: PAPL
Evolution
PAPL is found in holozoa but lost from most arthropods. Humans have a single member, PAPL (aka ACP7, PAPL1), but many invertebrates have multiple members, including 3 members each in Monosiga, Nematostella, sponge, and sea urchin. These appear to be independent expansions by protein sequence similarity, and in sea urchin, they form a tandem duplication cluster.
Domain Structure
PAPL has a phosphatase domain and most members have an N-terminal signal peptide cleavage site. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).
Function
Unclear.
