Difference between revisions of "Phosphatase Subfamily PPIP5K"

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=== Functions ===
 
=== Functions ===
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Human PPIP5K1 and PPIP5K2 mediates phosphorylation of InsP6 and 5-InsP7 to 1-InsP7 and InsP8, which are multifunctional signaling molecules that regulate diverse cellular activities <cite>fridy07, choi07</cite>.
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This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways.
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Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096])
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Revision as of 03:30, 2 January 2015

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: PPIP5K


Evolution

PPIP5K is conserved across opisthokont. Human genome has three copies.


Functions

Human PPIP5K1 and PPIP5K2 mediates phosphorylation of InsP6 and 5-InsP7 to 1-InsP7 and InsP8, which are multifunctional signaling molecules that regulate diverse cellular activities [1, 2].

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