Difference between revisions of "Phosphatase Subfamily PPM1E"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]]
  
The subfamily is named named after two human PPMs, [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g and PAK, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
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The subfamily is named named after two human PPMs, [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g <cite>Takeuchi01 Takeuchi04 Ishida05</cite> and PAK <cite>Koh02</cite>, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
  
 
The subfamily has some potent inhibitors <cite>Ishida07</cite>.
 
The subfamily has some potent inhibitors <cite>Ishida07</cite>.
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== References ==
 
== References ==
 
<biblio>
 
<biblio>
 +
#Koh02 pmid=11864573
 
#Ishida07 pmid=17897624
 
#Ishida07 pmid=17897624
 
#Ishida05 pmid=15680915
 
#Ishida05 pmid=15680915
#Takeuchi2014 pmid=15496589
+
#Takeuchi04 pmid=15496589
 +
#Takeuchi01 pmid=11726284
 
</biblio>
 
</biblio>

Revision as of 04:20, 6 May 2014

Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E

The subfamily is named named after two human PPMs, PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N) and PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g [1, 2, 3] and PAK [4], and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).

The subfamily has some potent inhibitors [5].


References

  1. Takeuchi M, Ishida A, Kameshita I, Kitani T, Okuno S, and Fujisawa H. Identification and characterization of CaMKP-N, nuclear calmodulin-dependent protein kinase phosphatase. J Biochem. 2001 Dec;130(6):833-40. DOI:10.1093/oxfordjournals.jbchem.a003055 | PubMed ID:11726284 | HubMed [Takeuchi01]
  2. Takeuchi M, Taniguchi T, and Fujisawa H. Identification and characterization of nuclear localization signals of CaMKP-N. J Biochem. 2004 Aug;136(2):183-8. DOI:10.1093/jb/mvh109 | PubMed ID:15496589 | HubMed [Takeuchi04]
  3. Ishida A, Tada Y, Nimura T, Sueyoshi N, Katoh T, Takeuchi M, Fujisawa H, Taniguchi T, and Kameshita I. Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction. Arch Biochem Biophys. 2005 Mar 1;435(1):134-46. DOI:10.1016/j.abb.2004.11.022 | PubMed ID:15680915 | HubMed [Ishida05]
  4. Koh CG, Tan EJ, Manser E, and Lim L. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr Biol. 2002 Feb 19;12(4):317-21. DOI:10.1016/s0960-9822(02)00652-8 | PubMed ID:11864573 | HubMed [Koh02]
  5. Sueyoshi N, Takao T, Nimura T, Sugiyama Y, Numano T, Shigeri Y, Taniguchi T, Kameshita I, and Ishida A. Inhibitors of the Ca(2+)/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N). Biochem Biophys Res Commun. 2007 Nov 23;363(3):715-21. DOI:10.1016/j.bbrc.2007.09.022 | PubMed ID:17897624 | HubMed [Ishida07]
All Medline abstracts: PubMed | HubMed