Difference between revisions of "Phosphatase Subfamily PPP4C"
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PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX. | PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX. | ||
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| + | PP4 in ''C. elegans'' is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene <cite>sato-carlton14</cite>. | ||
=== References === | === References === | ||
<biblio> | <biblio> | ||
</biblio> | </biblio> | ||
Revision as of 17:59, 5 January 2015
Phosphatase Classification: Fold MTDP: Superfamily MTDP: Family PPP: Subfamily PPP4C
Contents
Evolution
PPP4C is found in opisthokonta and amoebazoa, often one copy per genome.
Domain
PPP4C has a single domain - phosphatase domain.
Functions
PPP4C, catalytic subunit of Protein Phosphatase 4 (PP4) holoenzyme, is closely related to PPP2C, the catalytic subunit of PP2A holoenzyme. Like PP1 and PP2A, holoenzyme PP4 consists of the catalytic subunit and one or two regulatory subunits. At least 6 different holoenzyme complexes have been found.
PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX.
PP4 in C. elegans is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene [1].
