Difference between revisions of "Phosphatase Subfamily PXYLP1"

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=== Evolution ===
 
=== Evolution ===
PXYLP1 is found in bilateria, but ''Entamoeba histolytica'' and ''Emiliania huxleyi'' have PXYLP1 like genes.
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PXYLP1 is found in bilateria.
  
 
=== Domain ===
 
=== Domain ===

Latest revision as of 22:55, 25 October 2016

Phosphatase Classification: Fold HP: Superfamily HP: Family HP, branch 2: Subfamily PXYLP1

Evolution

PXYLP1 is found in bilateria.

Domain

PXYLP1 has a N-terminal transmembrane region and C-terminal phosphatase domain.

Functions

Human PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans . In collaboration with kinase FAM20B, it regulates the transient phosphorylation of the Xyl residue in the glycosaminoglycan-protein linkage region, which controls the formation of glycosaminoglycan chains of proteoglycans [1].

Related kinase

FAM20B.

References

  1. Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-6708. DOI:10.1074/jbc.M113.520536 | PubMed ID:24425863 | HubMed [koike14]