Gene PAPL-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP167_AA protein Get Run
AqueP167_AA_264-480 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 220-322 3.8e-08 23.7 Pfam-A 62-151 (453) alignment 
Range on Protein: 220-322
Range on HMM: 62-151/453.0
HT--AKLSGLTPGQEYNYQFGD--DPEWSQVFSFRMPPAPSPNAsITFIAFGDMGQAQ-VddtlrplyvhaqppaVNNTNLMAKEvNERDLVLHIGDISY
.|  ....|| ||||| |.|    . . |.| ..|  |. .... ... .....   |                 .|  . .|.. .. |.|||.||. |
ytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaves.lrlavvSCsnyeqGy...............fnayrelaek.edlDfvlhlGDyiY

AIGYaGVW
. |  |..
eyge.gty
PAPL 265-480 3.7e-51 166.0 In-house 2-194 (194) alignment 
Range on Protein: 265-480
Range on HMM: 2-194/194.0
AFGDMGQAQVDDtlrplyvhaqppavNNTNLMAKEVNERDLVLHIGDISYAIGYAGVWDEFF--DLIQPISSRVPYMVCGGNHERDYPHSGSYYEGTDSG
.|||.||.. .               ...   ... .. |..||.||..|| ..   ||..   ..|.|....|||||. ||||..| .|..... ...|
vfGDlGqtnass..............lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpg

GECGVPYEMrfqmprpDPKQHWYDFSLGSVHFVLMSTEIDFTVNSVQYNWLKDHLSSVDRSVTPWLIFAGHRPMYIDSDYgllpSSDLVVSKELQDNIEP
.|.|  ...       . ... | |. .||||. .|.| |.. .| ||.||.  |..|.||.|||.|..||||||  ..     ..|   ... ....|.
seegesnss.......esgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkd....kddckekakmlaaled

LLLEYKVDLAFWGHHHSY
||..|.||| ..||.|||
llykygVDlvlaGHeHsY
subfamily_ACP5_pd Subfamily ACP5 266-481 1.4e-65 212.8 In-house 2-189 (189) alignment 
Range on Protein: 266-481
Range on HMM: 2-189/189.0
FGDMGQAQVDDTLRPLYVHaqppavnntnlmakEVNERDLVLHIGDISYAIGY--AGVWDEFFDLIQPISSRVPYMVCGGNHERDYphSGSYYegtdsgg
|||.|. . ... . |. .              | || ||..|.||..|| ..  . |||||..||.|..|.|||||. ||||.|.  . |.|       
fgDlgvseaaslatllkee..............eaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesds..nfsay.......

ecgvpyEMRFQMPrpdPKQHWYDFSLGSVHFVLMSTEIDFTVNSVQYNWLKDHLSSV-DRSVTPWLIFAGHRPMYIDSDYGLLPSSDLV-VSKELQDNIE
      ..||.||    |..|| | .|.|||. .|||.||...| ||.||...|... .|. |||.|..||||||......   ... . |.|.|....|
......kkrfsmp...sknewYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresle

PLLLEYKVDLAFWGHHHSYQ
.|| .||||||..||.|||.
dllykykvdlalsgHeHsYe
Metallophos Calcineurin-like phosphoesterase 284-480 7.2e-20 65.1 Pfam-A 10-200 (200) alignment 
Range on Protein: 284-480
Range on HMM: 10-200/200.0
HAQPPAV---NNTNLMAKEVNERDLVLHIGDISYAIGYAGVWDEFF-DLIQPISSRVPYMVCGGNHERDYPHSGSYYEGTDSGGECGVPYEMRFQMPRpd
| ..       .  |.. . .. ||||. ||....  ..  .   .  | ....  .|.... |||| |.  | ..   . ..   | ...   . ..  
HgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenl..

pKqhwYDFSLGSVHFVLMSTEIDFTVNSVQYNWLKDHLSSVDRSVTPWLIFAGHRPMYIDSDYGLLPssdlVVSKELQDNIEPLLLEYKVDLAFWGHHHS
 |   . .  .|. ..  | .  .. .|.|. .|.  |  ..|. ... |. .|.|.. . ..|. .           |. |.||..|.||| ..|| | 
.k...itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi....gselfgpdalekllekygvdlvlrGHtHk

Y
.
p
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 293-482 7.7e-08 24.5 Pfam-A 16-123 (156) alignment 
Range on Protein: 293-482
Range on HMM: 16-123/156.0
TNLMAKEVNERDLVLHIGDISYAigyagvwDEFFDLIQPIssrvPYMVCGGNHErdyphsgsyY----------Egtdsggecgvpyemrfqmprpdpkq
.. . ....| ||.|| ||.          .|...|.. |    |  .. |||.         .                                    
leavledikevdlilhaGDlvep.......eevvelledi....pvlavrGnhD.........eaelpkelavel.........................

hwydfslgsvhfvlMSTEIDFTVNsvqynwlK-----------DhlssvdrsvtpwlifaghrpmyidsdygllpssdlvVSkELQDNIEPLLLEYKVDL
              .... .....       .           .                                    |  . ..... || |...||
..............llaaaaleie.......gdrvllvhgtpls....................................vq.sseeelaellkeagadl

AFWGHHHSYQR
.| || | .. 
vflGHtHkpkv
ACP5 296-479 2.6e-10 32.3 In-house 24-198 (198) alignment 
Range on Protein: 296-479
Range on HMM: 24-198/198.0
MAKEVNERDLVLHIGDISYAIGYAGVWDEFF-----DLIQPISSRVPYMVCGGNHERDYPHSGSYYEGTDSGGECGVPYEMRFQmprpdpKQHWYDFSLG
 . | .. | || .||  |  | ..| |. |     .  .  | .||..|. |||.     |    .   |  .  ...  ...      |..  .    
kvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslrysls......kkevvtelft

SVHFVLMSTEIDFTVNSVQYNWLKDHLSSVDRSVTPWLIFAGHRPMYIDSDYGllpssdlvVSKELQDNIEPLLLEYKVDLAFWGHHHS
. .   .... . . .. . ..||.  ... .| . |.| .|| |.|  .  |         .|||.....||| .||||. . || |.
ekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehg........dtkelverllpllkkykvdaYlnGHdHc
subfamily_PAPL_pd Subfamily PAPL 397-479 3.6e-09 28.1 In-house 140-211 (212) alignment 
Range on Protein: 397-479
Range on HMM: 140-211/212.0
MSTEIDFTVNSVQYNWLKDHLSSvdrSVTPWLIFAGHRPMYIDSDYGllpssdlvVSKELQDNIEPLLLEYKVDLAFWGHHHS
... .| .... |..||...|..   |   .|| ||| |..  .. |          |.|.....||| .|.|.  . || |.
legpvdvslaeeqwawleeeLka...seadylivaGhypvwsvaehG........ptkiLvkrLkPlLekynvtaylsGhDhn
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 496-557 2.3e-14 44.9 Pfam-A 1-62 (62) alignment 
Range on Protein: 496-557
Range on HMM: 1-62/62.0
TAPVHVVIGMAGHSLSTnIQNKQPDWIRFvDVDDYGYTRIS-VSPLSLTLEYIKSD-GTTKDTF
.||||.|.|.||..||.  ...||.| .| . .||||.|.. |    |..|...|| |.  |.|
kApvhIvvGaAGnglsk.fskpqpewsaf.resdyGysrltvvNrthLhwefvrsddgqvlDsf