Gene PAPL-5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP170_AA protein Get Run
AqueP170_AA_131-327 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 86-172 9.8e-08 22.4 Pfam-A 60-147 (453) alignment 
Range on Protein: 86-172
Range on HMM: 60-147/453.0
KRFVHRVKLSDLKPSTKYDYQCGS--SANWSSLYTMRTLGSGPDYSPVFLVYGDLGYDN--AQSLSRIRAEvnaGGIDAILHVGDLAYDMF
. .  .|....|.|...| |.  .  . . | .  .||| ..   |  ..|...  | .   . .......     .|..||.||  |   
rdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaveslrlavvSCsnyeqGyfnayrelaek...edlDfvlhlGDyiYeyg
Metallophos Calcineurin-like phosphoesterase 132-315 2.1e-22 73.4 Pfam-A 3-200 (200) alignment 
Range on Protein: 132-315
Range on HMM: 3-200/200.0
FLVYGDLGYDNAQS---LSRIRAEVNAGGIDAILHVGDLAYDMFEDDGRKGDNFmNMIQNVSTQIPYMTLPGNHEYSHIDIGSVHFIMFS----------
.|| |||.......   | .. .    ...|..|. ||| .   . ..  ..   .  ....  ||.. |.||||.....  . ...  .          
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------TEVYFFTDFGKEQIQTQYQWLEEDLKKATTPEALSERPWIITMGHRPMYCSTTNSNDCdhktsvtrtGTSDLHLYPLEKLFYNYGVDMF
           |  .....   .   ..    || |..   ... .  ...| ..|.|...|. ...|          |  .   . ||||...||||. 
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.........gselfgpdalekllekygvdlv

ISAHEHIY
...|.| .
lrGHtHkp
ACP5 132-205 8.3e-08 24.1 In-house 1-81 (198) alignment 
Range on Protein: 132-205
Range on HMM: 1-81/198.0
FLVYGDLGYDNAQSLSRIRAE----VNAGGIDAILHVGDLAYDM---FEDDGRKGDNFMNMIQNVSTQIPYMTLPGNHEYS
||| || | ... . |.. ..    ..  .||..| .||  ||     .|| |  ..| .. .. |.|.|.... |||.| 
flvvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyr
subfamily_ACP5_pd Subfamily ACP5 134-316 7.1e-62 200.7 In-house 1-189 (189) alignment 
Range on Protein: 134-316
Range on HMM: 1-189/189.0
VYGDLGYDNAQSLSRIRAEVNAGGIDAILHVGDLAYDMFEDDGRKGDNFMNMIQNVSTQIPYMTLPGNHEYS-------------------HIDIGSVHF
|.||||...|.||...  | .|. .|.|.|||||||.. ..... .|.|||.|.......|||...||||..                   ..|.|.|||
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmpsknewYsfdygpvhf

IMFSTEVYFFTDfgkeqiQTQYQWLEEDLKKATtpeALSERPWIITMGHRPMYCSTTNSNDCDHKTSVTRTGtsdlHLYPLEKLFYNYGVDMFISAHEHI
|..||||.|...      ..||.|||.|||.|.     ...||||.|||||||||.....||.......|.|    . . ||.|.|.|.||...|.|||.
islstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg....lresledllykykvdlalsgHeHs

YE
||
Ye
PAPL 134-315 1.3e-51 167.5 In-house 2-194 (194) alignment 
Range on Protein: 134-315
Range on HMM: 2-194/194.0
VYGDLGYDNAQSLSRIRAEVNAGGIDAILHVGDLAYDMFEDDGRKGDNFMNMIQNVSTQIPYMTLPGNHEYSHIDIGSV--------------------H
|.||||..||.||.|...|.. | .|||||||||||.. |.....||.||..|.......|||..|||||. .   ...                    .
vfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgsn

FIMFSTEVYFFTDFGKEQIQTQYQWLEEDLKKATTPEALSERPWIITMGHRPMYCSTTNSNDCDHKtsvtrtgtsDLHLYPLEKLFYNYGVDMFISAHEH
 . |.||...|.....|.  .....  |.|...  ..  |..||||.|||||||||.....||..|         . .|. ||.|.|.||||.....|||
sysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckek.........akmlaaledllykygVDlvlaGHeH

IY
 |
sY
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 142-353 9.3e-09 27.5 Pfam-A 12-141 (156) alignment 
Range on Protein: 142-353
Range on HMM: 12-141/156.0
NAQSLSRIRAEVNAggIDAILHVGDLAYdMfeddgrkgDNFMNMIQNVstqiPYMTLPGNHEyshidigsvhfI----------Mfstevyfftdfgkeq
| ..|... ....   .|.|||.|||   .        . ........    |  ...|||.                      .               
nldaleavledike..vdlilhaGDlve.p........eevvelledi....pvlavrGnhD...........eaelpkelavel...............

iqtqyqwleedlkkattpealS---------ERPWIITMGHRPMycsttnsndcdhktsvtrtgTSDLHLYpLEKLFYNYGVDMFISAHEHIYERmwpiy
                               .. .... |..                        . . . |..|. ..|.|.....| | ..      
.....................llaaaaleiegdrvllvhgtpls....................vqsseee.laellkeagadlvflGHtHkpkv.....

dykvlngsydapyTNPKGPIHIVTGSAGCRE
             .  .| .....||.| . 
.............ekrggtlvvnpGsvgepr
ACP5 232-313 1.1e-06 20.5 In-house 129-197 (198) alignment 
Range on Protein: 232-313
Range on HMM: 129-197/198.0
IQTQYQWLEEDLKKATTPEALSERPWIITMGHRPMYcsttnsndcdhktSVTRTGTSDLHLYPLEKLFYNYGVDMFISAHEH
 ... .  || ||. ..  | |.  |.| .|| |.|             |. . | ..  .. |. |. .|.||.... |.|
vaerekyaeeqlkwlekalakstadwkiVvGHhpvy.............SigehgdtkelverllpllkkykvdaYlnGHdH
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 339-402 1.3e-21 68.1 Pfam-A 1-62 (62) alignment 
Range on Protein: 339-402
Range on HMM: 1-62/62.0
KGPIHIVTGSAGCRERHaTFSPKPDWVALTSSDYGYTRMTVHSKTQISFEQISDDqNGKIVDSF
|.|.|||.|.||... .   .|.|.| |. .|||||.|.||. .| ...|....| .|...|||
kApvhIvvGaAGnglsk.fskpqpewsafresdyGysrltvvNrthLhwefvrsd.dgqvlDsf