Gene PPP4C in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP179_AA protein Get Run
AqueP179_AA_4-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP4C_pd Subfamily PPP4C 5-292 1.5e-182 598.2 In-house 1-288 (288) alignment 
Range on Protein: 5-292
Range on HMM: 1-288/288.0
SDLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRY
||||||||.|||||.|||.|||.||.|||||| ||||||||| |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDID
|||||||||||||||||||||||||| |||||.||||||||.|||||||||||..||.|||||||||...|.||.|||||||||.||.||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNE
||..||||||||||.|||..||.||.|.||||||||||||||.||||.|||||||||||||||||||||||||.|..||.|||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 5-291 1.6e-155 509.5 In-house 2-288 (290) alignment 
Range on Protein: 5-291
Range on HMM: 2-288/290.0
SDLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRY
.|||..||.|..|. ..|.|||.|| ||.||||.||||| |  |||||||.||||.|| ||||.||..|.||||||||.||||.|||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDID
..|||..||||||||||||||||||| ||||. |||.| |..||||.|.|..||.||..||||||||...|.|||.|| |||||.||.||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPN
||||||||||| ||.|.  .|| .|.. || ||||||||||.| ... | |..||||||||||| |||||||..||. |  |..||.
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
0045823 Metallo-dependent phosphatases 5-294 6.4e-124 407.0 In-house 28-329 (473) alignment 
Range on Protein: 5-294
Range on HMM: 28-329/473.0
SDLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRY
.|||. ||.|.......| ....|...|.|||..|.|.........|.||||||..||..|..  |  ||....||||.|||| .|.|...||||||..|
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PDRITLIRGNHESRQITQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDID
|....|.|||||.|.....|||.||. .|| ........ | ...| |||.|...|. |||||||.....||||.|.| .|.|.||...|||||||...|
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

G--------WGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNET------VLTVWSAPNYCYRCGNVAAILELDENLkRDFTIFEAAP
|        .| |||||||||| |.| || . |..|||.|.|. |.|||...|.        ..||.||||||.|.|| ||.|..||.| . |..|...|
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

NEVR
 ...
hpli
0049330 Metallo-dependent phosphatases 5-293 1.1e-114 375.6 In-house 15-303 (309) alignment 
Range on Protein: 5-293
Range on HMM: 15-303/309.0
SDLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRY
|.||..||.|... ...|.|.. |. ||.||| .|.|..... ...|.||||||..||..|..  | .||....||||.|||| .|.|..|||||||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRITLIRGNHESRQITQVYGFYDECKRKYGsVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPE-DI
||...|.|||||.|.....|||.||..|||| ...|..... ...| |||.|...|. |||||||.....||||...| .|.|.||..||||||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

DGWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNEV
.|.. .|||.|..|| ..| .|   |..|||.|.|..|..||...|.. ..||.||||||.|.||..|.||.||.|.. |..||..| ..
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
0053225 Metallo-dependent phosphatases 5-290 4e-111 364.0 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SDLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRY
..||..||.|... ...|.|.. |. .|.|||..|.|..... ...|.|||||...||..|..  | .||....||||.|||| .|.|...||||||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDID
||...|.|||||.......|||.||..||||. ..|..... ...| |||.|...|. |||||||.....|||| |.| ...|..|...||||||| ...
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAP
||..|.||.|..|| ..| .|  .|..|||.|.||.|..||...|.. ..||.|||||..|.||..|.|.|||.|...|..|.. .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP6C_pd Subfamily PPP6C 6-293 6.5e-152 497.6 In-house 1-288 (290) alignment 
Range on Protein: 6-293
Range on HMM: 1-288/290.0
DLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYP
.||. ||. ..|. . |...| ||..  ..|.|||||| |  |||||||||||||||.|||. ||.||.|.|.|||||||||.||.||| .||.||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDIDG
|||||.|||||||||||||||||||..|||..|.|.|||..|| |..||||||... ||||||| .. .|||| |.| ||.||.|..|||.||||||.. 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNEV
| .||||||||||. |..||.. ||..|||||||||.||.|..|.| . ||||||||||||||||.||.|... .|.. .|.| |.| 
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdee
subfamily_PPP7C_pd Subfamily PPP7C 6-184 9.8e-40 129.4 In-house 19-203 (383) alignment 
Range on Protein: 6-184
Range on HMM: 19-203/383.0
DLDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDP----PVTVCGDIHGQFYDLKE-LFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLAL
.... ||.... .... . |  .  .|...| .  |..||       ||||||.||.. ||   |.| |   .| .|.| |||||||  |||  |.||||
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KVRYPDRITLIRGNHESRQITQVYGFYDECKRKY--GSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSpSITSIDQIRAIDRKQ
 . ||  . | |||||   .   |||  | . ||   . .. |   ..| .| ||..|||.|. ||||.|  .|... .  |.|..
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPG1_pd Subfamily PPG1 7-292 7.9e-133 435.3 In-house 1-299 (300) alignment 
Range on Protein: 7-292
Range on HMM: 1-299/300.0
LDRQIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPD
||. .|.|...|.. |  ||.|. | .|.| .||||...  |||| ||.||||||. |.||.||.||.||||||||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYDECKRKY-GSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPE----
||||.|||||||||||||||| || ||| |  .||.| |||||||.||||||| |..||||||||. |||||. .|| .|||..| ..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DIDG--WGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNE
      | .|  . .|.||||| .|.||| .|   |... | |||||..|||. .|.. . |||||||||||||| |.|||| |...| | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-289 5.3e-97 317.4 In-house 14-294 (298) alignment 
Range on Protein: 10-289
Range on HMM: 14-294/298.0
QIEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRIT
 ... . ..||||..|..|...|..|... . .  ||.|..||||||||. ||  ||. .|  |..|||||||.|||| ...|. .|||| ||.||... 
slsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnff

LIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPED-IDGWGI
|.|||||  .| .|||||.||||.| |....    ..|. | |.|.| .||. .|||||. ..|.||.|.. | .. ...    ||||.|||. . ||  
llrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwae

SPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAA
. ||... ||.||| .. .  .|||..||||.| .||..  .  ..|..|||.|| .  | ||....||.|.  |...  .
nsrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPP5C_pd Subfamily PPP5C 11-290 5.8e-85 278.1 In-house 25-310 (322) alignment 
Range on Protein: 11-290
Range on HMM: 25-310/322.0
IEQLRRCEVIKEQEVKSLCSKAREILSEESNVQRVDP----PVTVCGDIHGQFYDLKELFKVGGDVPET-NYLFLGDFVDRGFYSVETFLLLLALKVRYP
.|...  . .... . .. ..|.|.|.... .  ..      .||||||||||||| ..|.. | . |.  ||| ||||||| .|||. |.||..|. ||
lelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyP

DRITLIRGNHESRQITQVYGFYDECKRKYGSvNVWRYCTEIFDYLSLAAIIDERIFAVHGGLS-PSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDID
... | |||||| .. ..||| .|.| || . .|    ||.|..| || .|.|... |||||      ..|..| ||| .. |..| ...||||||..  
nhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqean

GWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILEL-DENLKRDFTIFEAAP
| . | || |  || || ..|   ||..|| |.|.. .|||. . .  ..||.|||||| . || .|...| ...||  |. ||| .
GrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_PPP3C_pd Subfamily PPP3C 14-279 3.1e-86 282.9 In-house 35-313 (452) alignment 
Range on Protein: 14-279
Range on HMM: 35-313/452.0
LRRCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRG
. .   ..|...  . ..| ..|..|... .|. |.||.|||||||||| .||.||||  .|.||||||.|||| .|.|. | |.|||. ||... |.||
flkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrG

NHESRQITQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPED-IDGWG-----
|||.| .|. . | .||| || | .|.  |.| || | |||..... . ||||||| |.|.|.|. .|| .|.|. ||.|||||||| .  .        
nhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekf

--ISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFN------ETVLTVWSAPNYCYRCGNVAAILELDENL
   |.||  |...   |.||  .|..  | |||.   .||. . .       ...|..|||||.    | ||.|....| 
vpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 15-294 9.7e-85 277.1 In-house 3-280 (280) alignment 
Range on Protein: 15-294
Range on HMM: 3-280/280.0
RRCevIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGN
 .|  ||| .....  | ..||. .. .  || ||.||||.|||. ||  ||.  .  |..|||||||.|||| . .|  ||||| |||||... ..|||
lac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPE-DIDGWGISPRGA
||  .| . |||.||.||.| | ...    |..| | |.|..  ||. .|||||. . |.|... . |  . ...    ||||.||| .. ||. ..||.
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNEVR
 ..||..|| ..    .||||.| ||.| .||..  .  ..||.|||.|.    | ||.| .||.|.  | ..  |  ||.
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrevk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 16-293 2.5e-86 282.6 In-house 20-298 (299) alignment 
Range on Protein: 16-293
Range on HMM: 20-298/299.0
RCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNH
  . .||||...||. |.... ... .  |..|. ||||||||. ||  .|.. |  |..|.|||||.||||   .|.  |||. |..||.|. ..||||
ltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnh

ESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPED-IDGWGISPRGAG
|   | .|||||.||...| |  .|    . |... |. .|  ||...|||||| ....||.| . | |. |      ||||.||.. . .|    ||  
ecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvs

YLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNEV
|.||.|||..  |  .|||..||||.| .||..  .  ..|..||| || .  | |||...||||   |.... .|...
yvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 16-287 5.6e-77 251.9 In-house 19-293 (297) alignment 
Range on Protein: 16-287
Range on HMM: 19-293/297.0
RCEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNH
 ..|| |. |  |   | ...  . ..  |. |. ||||||||| ||  ||. ||  | .|||||||.|||| .|.|| .|||| ||..|  . |.||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSIT---SIDQIRAIDRKQEVpHDGPMCDLLWSDPE-DIDGWGISPR
|   . .|||||.||...| || ..    ..|..| |. .| ..|...|||||| .|   ..| .| |.| .|  ... ..||||.||   . |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFE
|||  || | | .  |  ..||.|||||.| .||..     ..|..||| || .  |.||..  ||.|.  | |. 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-284 3.1e-73 239.7 In-house 3-270 (280) alignment 
Range on Protein: 17-284
Range on HMM: 3-270/280.0
CEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
|.|.  .|. ..      |. ||||.   . |. | |||| |. |.. || . | ||| . .||||.||||   .| ..||..||.|| ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECKRKYGsVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPED-IDGWGISPRGAGY
.  . ..|||| ||. ||| | .|     .|. . ....| .|....|||||| .  .| || | |  |    | . ||||||| .  .||  | ||  |
tpsvnkiygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFT
.||. || .   . .|||| ||||.| .||.      ..||.| |||| .  | ||.. |. ||.  | 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 17-286 5.3e-66 215.6 In-house 13-286 (290) alignment 
Range on Protein: 17-286
Range on HMM: 13-286/290.0
CEVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
 . ...... ..  |..|||     . .|  |... ||||||. .| . |.  |  |. ..|||||.||||  |.|  |||. .|.||. .. |.|||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

SRQITQVYGFYDECKRKYGSvNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQ--EVPHDGPMCDLLWSDPED--IDGWGIS-PR
 |.. ..|||..|  || || ..|.   ..|. ||| | ....|. .|||.|. | | . ..|. . .     ..| . ||||.||.    |   .   |
vrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIF
.   .||.... ..     ..|| |||..  ||... |.. ..||.||| |. .  |. ||... | |.  ....
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-287 1.2e-84 277.1 In-house 6-281 (284) alignment 
Range on Protein: 18-287
Range on HMM: 6-281/284.0
EVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDV------PETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLI
...||.|.  || .|||.. .|.  . .. ||...||||||| ||. |... |         |..||||||.|||| .|.|  .||.|.|...||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPE-DIDGWGISP
||||||| . . |||| |||..| |....      |  . |.|.....|. .|||.|  . ...|. ...|  ..|  | ..|| |.||| ...|.  ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFE
|||| .||.. | ||.   ..||. ||||.||.||..  .  ..|..||| || .  |.||.|..||.|   ||...
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 18-286 2.7e-82 269.2 In-house 5-274 (281) alignment 
Range on Protein: 18-286
Range on HMM: 5-274/281.0
EV-IKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
.| . ..|....  ... |.|||...  .|.|..| ||.|.|| |||.||.. | |||. ..||||.||||  |.|...||..||.||.||| |.|||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

SRQITQVYGFYDECKRKYGsVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPED-IDGWGISPRGAGY
  .. ..|||| ||. ||| ...|    . |. | ..| |..|.  .|||||| .|..|..| . .  . .. | . ||||.||..   .|  | ||...
iasvnkiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

LFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIF
.||..|| .     ...|| ||||.|..||.      ..||.|.||||    | ||.| .||.|. ..  .
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 18-288 2.3e-74 242.9 In-house 8-281 (287) alignment 
Range on Protein: 18-288
Range on HMM: 8-281/287.0
EVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
. ...... ..  |..|||   . . .|. |.|..||||||. ||  .|.  |  |...||||||.||||  |.|  |||..||..|| .. |.||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECKRKYGsVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQE--VPHDGPMCDLLWSDPE-DIDGWGIS-PRGA
..| ..|||..| |||..  ....   ..|..|.| |....||. .|||.|| . |.|...|. . .     ..| . ||||.||| | ..  .   |. 
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

GYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEA
  .||. .| ..    .|||| |||... |||.. |.. ..||.||| |. .  |..|.. ... |.  |. .  
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 18-282 1.8e-56 184.5 In-house 4-293 (302) alignment 
Range on Protein: 18-282
Range on HMM: 4-293/302.0
EVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKV-----------GGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPD
.. ...|. .|...  | |..|... .. ||||. ||||||| ||  ...                 .  ..||||.||||  |.|   |..|||| || 
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITLIRGNHESRQITQVYGFYDECKRKYGSVN---VWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRK-QEVPHDGPMCDLLWSDPED
.  |.|||||.. |   ||| .| . ..|  .   .|.   |.| .. |||.. |.|. ||||.|| ..|...|. |.|  .|| .|    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

IDGWGISP----------RGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRD
...  . .          ||  ..| .  | ..    |..|| |||| . ||.|.. .. .||..|||.|     |  |.|..| | |  
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 18-282 2.6e-56 184.0 In-house 5-294 (302) alignment 
Range on Protein: 18-282
Range on HMM: 5-294/302.0
EVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKV-----------GGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPD
.. ...|. .|...  | |..|... .. ||||. ||||||| ||  ...                 .  ..||||.||||  |.|   |..|||| || 
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITLIRGNHESRQITQVYGFYDECKRKYGSVN---VWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRK-QEVPHDGPMCDLLWSDPED
.  |.|||||.. |   ||| .| . ..|  .   .|.   |.| .. |||.. |.|. ||||.|| ..|...|. |.|  .|| .|    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

IDGWGISP----------RGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRD
...  . .          ||  ..| .  | ..    |..|| |||| . ||.|.. .. .||..|||.|     |  |.|..| | |  
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-70 2.7e-13 42.8 In-house 7-59 (317) alignment 
Range on Protein: 18-70
Range on HMM: 7-59/317.0
EVIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGG
...||.|.  || .|||.. .|    ... |||..||||||| ||. |... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPP1C_pd Subfamily PPP1C 19-288 1e-107 352.5 In-house 9-278 (282) alignment 
Range on Protein: 19-288
Range on HMM: 9-278/282.0
VIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 .||.|...|..|||||| ... . ... ||...||||||..||  ||. .|  ||.|||||||.||||  |.|| .||||.|..||... |.|||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECKRKYGSVnVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPE-DIDGWGISPRGAGYLF
.|...|||||||||.|..  .|.  |..|..| |||..||.|. |||||||...|..||| | |  |||..| .||||||||. .. ||. . ||  . |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEA
|.|||..| . |..|||.||||.| .||... .. ..||.|||||| . .| .|.|..||.|. .|.|. .
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_PPZ_pd Subfamily PPZ 19-286 1.2e-78 257.6 In-house 24-291 (300) alignment 
Range on Protein: 19-286
Range on HMM: 24-291/300.0
VIKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
..|..|.  .| ||||..  . ..  . |.| . ||.|||. ||  ||   |  | .|||||||.||||  |.|| ||||. |..||. . |.|||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPEDI-DGWGISPRGAGYLF
..|.||||||||||.   ...|.   . |. | ||||.  .||.||||||| . |.|.|| . |  .||  | . ||||||| |  . |    ||  | .
nvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIF
 .  . .|     .||.|||| .| .||..  . ...||.||||||    |  |.. . | |   | ..
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfell
PPP_3 20-287 7.2e-122 398.6 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
IKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
..|.|.|.|..|..|||..|||..... |||||||||||..|| ||||.||..|||.||||||.|||| .|.|..|||||||..||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDL-LWSDPEDIDGWGISPRGAGYLFG
|..||||..|...|.|. .|.....|.|..|.|||.|||... |||||||||.|.|||. ..||.|||..|...|| |.||||. .|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

NDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFE
.||..||...|...||.|||.|..|||. .... |.||.||||||.|..|..|||.|.|.|...|...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 20-286 1.5e-70 230.8 In-house 3-271 (284) alignment 
Range on Protein: 20-286
Range on HMM: 3-271/284.0
IKEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
|  ..|..|  .| .|. ..  .  |. |. .|||||||| ||  ||   |    .|||||||.|||| . .|| |||.| || .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPM-CDLLWSDPEDI-DGWGISPRGAGYLF
| ..||||.||.|.|    |.     .|  . |.|.. .||...|||.|  .  . |.||| |  . |    .  |.||||| ..  ||    ||  |.|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIF
| | . ..    .|||. ||||.| .||..  |  ..|..||| || .  | ||.. ...||   | ..
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
PPP_1 21-274 4.2e-114 373.3 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
KEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
.|.|...|..|..|.|..|.|...|. ..||||||||||.|| .||||||..||||||||||.|||| .|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECKRKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDL--------LWSDPEDIDGWGISPRG
|.||||..|...|..| ......|..||.|.|||.|||.|. |||||||.....|||| ..||.|||..|..|||        |..|.|. ...  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
||||||.||...|...||..||.|||....|||.......|.|..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 21-288 3.6e-108 353.7 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
KEQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
...||..|.....|||..|.|. .|..||||.||||||..|| .|.. .| .||..|.||||.|||| .|.|. |||.|||..||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDP-EDIDGWGISPRGAGYLFGN
...|||..|.|||| . ...  ..|.|..|.|||..|..|. .||||||...|.|.|| ..| .| |..|...||||||| .. .|. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEA
|.|.|| ..||..||.|||..|.|||.. ... ..|..||||||....|.||.|....|||  .  ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 22-69 5.8e-08 25.2 In-house 13-60 (339) alignment 
Range on Protein: 22-69
Range on HMM: 13-60/339.0
EQEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVG
  |.  || .|||..  |  . ... |. | ||||||| ||  .. . 
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-287 2.6e-62 203.7 In-house 23-290 (307) alignment 
Range on Protein: 23-287
Range on HMM: 23-290/307.0
QEVKSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQ
.|.. .  .|. |.| |  .  .|||. | ||.|||| || ..| . |  ||| |.| ||.||||. |.|. |||.. |. ||. | |.|||||  .. .
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

VYGFYDECKRKYG--SVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDLLWSDPED-IDGWGISPRGAGYLFGN
 ||||.||         ..|      |. | ..|.|  .|...||||||..| .|..|   .    |  | . |.||.||.  .  |  | ||.|. || 
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgt

DVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFE
.|. .      ..|| ||||....||       ..|..||| ||    |  ..| .|| |  .   | 
nviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafv
subfamily_PPPLV_pd Subfamily PPPLV 26-276 1.6e-53 174.9 In-house 3-276 (290) alignment 
Range on Protein: 26-276
Range on HMM: 3-276/290.0
KSLCSKAREILSEESNVQRVDPPVTVCGDIHGQFYDL----KELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQIT
 |||..| .|| .| ..  .. |. | ||.||.. ||    | |...| |.  ...|||||.|||| .|||    |||||| || .. |.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECKRKYGSV--NVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAID---RKQEVPHDG-PM-CDLLWSDPEDI-----------
. . .. |.. |.|    .||   ...||.| |||.||...| ||.|.  .| .  .| ||.    . . . || |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-DGWG-ISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCgNVAAILELD
 .|.   . || |..|..| .  |   ||.. . |||.   .|..   .  .|||.|. .||    | ||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-294 4.9e-57 186.6 In-house 5-261 (263) alignment 
Range on Protein: 45-294
Range on HMM: 5-261/263.0
VDPPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECKRKYGSVNV----W
.. |. .||| |||. ||  .|.  |   .|.||||||.|||| .|.|  .||..||.  | .. |.||||| . | . |||. | |...   .|    .
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

RYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPM-CDLLWSDPEDiDGWGISP---RGAGYLFGNDVVSEFNSANNIDLICR
 .  ..| |. |.||. .||...|||.|| . |.|.||||    |  .  |. |||||.|||  |  |. |   |    .||.  | ..    .|||| |
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAAPNEVR
|||.|  || .  .  ..||.||  |     | ||.. ... |.  |  ..    |||
ahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevr
Metallophos Calcineurin-like phosphoesterase 48-240 9.9e-47 152.8 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----KELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLL--LALKVRYPDRITLIRGNHESRQITQVYGFYDECK----------
...|.||.||...||     .|.|.... . ...|||||.|||| .| ||. ||  |.||...|... |.||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSIDQIraidrkqevphdgpmcdllwsdpedidgwgi
                       ....  ...... |.|..|.|.|..| .|. .||.||.|  | |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYLFGNDVVSEFNSANNIDLICRAHQL
    ...|||.|.....   ...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 3.9e-82 267.7 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLKELFKVGGDVPETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEIFD
||||||.|||..|| .|||.|...||..||||||.|||| .|.|..|||||||..||....|.||||||.....||||..|...|.|. .|.....|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVPHDGPMCDL-----LWSDPEDIDGWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQL
.|.|||.|||... ||||||..|...|||. ..||.|.|..|...||     |....|. ...  | ||||.|||.||..|. ..|...||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 7e-78 254.2 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-KELFKVGGDVP-ETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECKRKyGSVNVWRYCTEI
|||.||||||..||  .|.|.||. . |..|.||||.|||| .|.|..|||||||..||....|.||||||......|||..|...|  . .........
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVP-HDGPMCDL-LWSDPE-DIDGWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQL
||.|.|||.|||... ||||||....|.|.|..|.||.|.| ... ..|| |||||. . .|.  | ||||.|||.||...| ..||..||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 1e-76 250.4 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-KELFKVGGDVP-ETNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECKRKYGSVNVWRYCTEI
||||||.|||..||  .||| ||| . |..|.||||.|||| .|.|..|||||||..||....|.|||||..|....|||..|...||.. .........
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLAAIIDERIFAVHGGLSPSITSIDQIRAIDRKQEVP-HDGPMCDL-LWSDPE-DIDG-WGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQL
||.|.|||.|||... |||||||.| ||.....|.||.|.| ..| ..|| |||||. . .| .  | ||||.|||.||...| . ||..||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 49-121 7.6e-06 18.6 In-house 12-80 (235) alignment 
Range on Protein: 49-121
Range on HMM: 12-80/235.0
VTVCGDIHGQFYDLKELFK--VGGDVPETNYLFLGDFVDRGFYSVETFLLLlalkvrYPDRITLIRGNHESRQIT
. | ||.|| . .| ||..  .||  ..   ...||....|  |||.  ..        |    ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-287 8.7e-72 234.9 In-house 101-313 (317) alignment 
Range on Protein: 75-287
Range on HMM: 101-313/317.0
TNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECKRKYgSVNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSI
 .||||||.|||| .|.|  .||.|||..|||...|.||||||| . . |||| |.|..| |....     .|  | |.|.....|. .|||.| .....
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRAIDRKQEVPHDGPMCDLLWSDPE-DIDGWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAIL
.|. ...|  ..|  | ..|| |.||. ...|.  |.|||| .||.. | ||.   ..||. ||||.|..||..  .  ..|..|||.|| .  |.||.|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDENLKRDFTIFE
..|..||  .....
svdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-287 3.2e-54 177.3 In-house 121-332 (339) alignment 
Range on Protein: 76-287
Range on HMM: 121-332/339.0
NYLFLGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECKRKYGSvNVWRYCTEIFDYLSLAAIIDERIFAVHGGLSPSITSID
 ||||||.|||| .|.|  .|| |||. ||||| |.||||||| .   |||| | . .| . ...    ..|. . ..|.|.. |...|||.|  .||..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRAIDRKQEVPHDGPMCDLLWSDPEDI-DGWGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
|.  . |  |.|  | . || |.||.    |.  | ||| ..||   .  |    ..... | ||.| .||..     ..|..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDENLKRDFTIFE
.|..||    .| 
idkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 192-289 2.7e-18 58.9 In-house 237-335 (383) alignment 
Range on Protein: 192-289
Range on HMM: 237-335/383.0
MCDLLWSDPEDIDG-WGISPRGAGYLFGNDVVSEFNSANNIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDENLKRDFTIFEAA
. |.|||||.  .| .  . ||.|  || || ... .  |..|. |.|.  .|||..  ...|||..|| ||     |  | . | ..|.  .  . |.
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas