Gene pph-4.1 in Caenorhabditis elegans

Synonym: CELE_Y75B8A.30, pph-4.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP152_AA protein Get Run
CeleP152_AA_24-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 25-320 8e-123 403.4 In-house 23-329 (473) alignment 
Range on Protein: 25-320
Range on HMM: 23-329/473.0
DQLTTHDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLA
. |.  |||. || |....|. | |.. |. .|.|||..| |.. .. .....||||||..||..|..  |  |.....||||.|||| .|.|...||||
illglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlellla

LKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYgNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSD
|| .||... |.|||||.|.....|||.||.|.|| ........ |....| |||||.||...|||||||.....|||| |.| .|.|.||...||||||
lkikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsd

PeEGNVG--------WGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEK------VLTVWSAPNYCYRCGNVAAILELDENLnKEFT
| .   |        .| ||||||||||.|| . |.. ||.|||.|.|. |.|||...|. |      ..||.||||||.|.|| ||.|..||.|  .|.
P.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfi

IFEAAPQENR
.|...|....
qfdpsphpli
0049330 Metallo-dependent phosphatases 25-318 5e-116 380.0 In-house 10-302 (309) alignment 
Range on Protein: 25-318
Range on HMM: 10-302/309.0
DQLTTHDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLA
..|....||. ||.|... |. |.....|. ||.||| .|.|.. .. .....||||||..||..|..  | .|.....||||.|||| .|.|..|||||
lelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllllla

LKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGnASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSD
|| .|||.. |.|||||.|.....|||.||.||||| |..|.........| |||||.||..||||||||.. ..|||| ..| .|.|.||..|||||||
lkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsd

PEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAPQE
| .   |.. .|||.|..||..| . |...||.|||.|.|..|..||...|..|..||.||||||.|.||..|.||.||.|. .|..||..|..
plpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 25-315 2.3e-98 321.9 In-house 4-294 (298) alignment 
Range on Protein: 25-315
Range on HMM: 4-294/298.0
DQLTTHDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLA
|.| .. |   ...   .. | |.||..|...|..|...   .  .|.|...|||||||. ||. ||. .|  |..|||||||.|||| ...|. .||||
dellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivllla

LKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSD
 |..||....|.|||||  .| .|||||.|| |.| . .....  .||. | |.|.| |...|.|||||. ....||.| . | .. ...    ||||.|
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwad

PEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAA
||.   ||  . ||... ||.|. | ..|.  .||..||||.| .||..  . |..|..|||.|| .  | ||....||.|   |...  .
penavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
0053225 Metallo-dependent phosphatases 26-316 5.8e-111 363.4 In-house 3-292 (293) alignment 
Range on Protein: 26-316
Range on HMM: 3-292/293.0
QLTTHDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLAL
.|.. .||. || |... |. |.....|. .|.||| .|.|.. .. .....|||||...||..|..  | .|.....||||.|||| .|.|...|||||
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDP
|..|||.. |.|||||.......|||.||.|||||.|..|.........| |||.|.||...|||||||..|..|||| |.| ...|..|...|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

EeGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAP
     ||. |.||.|..||..| . |...||.|||.|.||.|..||...|..|..||.|||||..|.||..|.|.|||.|. .|..|.. .
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP7C_pd Subfamily PPP7C 27-209 6.5e-38 123.4 In-house 15-203 (383) alignment 
Range on Protein: 27-209
Range on HMM: 15-203/383.0
LTTHDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVID----SPVTICGDIHGQFYDLME-LFKVGGPVPNTNYLFLGDFVDRGFYSVETFLL
||...... ||.. . .|.  . | ..  .|...| .  |.. .       ||.|||.||.. ||.  |.| | | .. .|.| |||||||  |||  |.
ltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveilli

LLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKY--GNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPsISTMDQIRVIDRKQ
||||   ||  . | |||||   .   |||  |   ||   .. . .   .|| .| ||..|| |.. ||||.|  .. .. .  |.|..
llalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisd.ktdlelldkiersk
subfamily_PPP4C_pd Subfamily PPP4C 30-318 5.2e-178 583.4 In-house 1-288 (288) alignment 
Range on Protein: 30-318
Range on HMM: 1-288/288.0
HDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARY
.||||.||||.|||||.|..||.||||||||| ||.||| .|||||.|||||||||||.||||||| ||.|||||||||||||||||||||||||||.||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGN
|||..||||||||||||||||||||||||||.|.||..||||||||||||.||||.|||||||||||||.|.||.|||||||||.||.|||||||||. .
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

vGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAPQE
 ||..||||||||||.|....|.|.|...||||||||||||||.||||||||||||||||||||||||||||||.|.|.|.|||||..|
.gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 30-318 9.1e-153 500.5 In-house 2-289 (290) alignment 
Range on Protein: 30-318
Range on HMM: 2-289/290.0
HDLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARY
.|||..||||..|. . |..||.|| ||.|||..| ||| . .|||.|||.||||.||.||||.|| .|.||||||||.||||.|||||  || ||| ||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEeGN
..|. ..||||||||||||||||||||||||||.|||. |..||||.|.|..|...||.||||||||.|.|.|| .|| |||||.||.||||||||.   
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.dr

VGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAPQE
 |||.||||||| || | |..| .|||. || ||||||||||.| ....| |..||||||||||| |||||||..|...|  |..||..
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP6C_pd Subfamily PPP6C 31-320 7.9e-148 484.2 In-house 1-289 (290) alignment 
Range on Protein: 31-320
Range on HMM: 1-289/290.0
DLDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYP
.||. ||   .|. ..|.|.| ||..  ..| ||.||| . ||||.|||||||||||.|||. || ||.|.|.|||||||||.||.||| .||.|||.||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNv
||..|.||||||||||||||||||||.|||||..||.||.||| |..||.||..|.|||||||| . |.||||||.| ||.||.|..|||.|||||. . 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedve.

GWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAPQENR
 | .||||||||||.  .| |...| ..|||||||||.||.|..|.||. ||||||||||||||||.||.|... ..|. .|.| |.|.|
twavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPG1_pd Subfamily PPG1 32-318 2.1e-132 433.9 In-house 1-299 (300) alignment 
Range on Protein: 32-318
Range on HMM: 1-299/300.0
LDRHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPD
||. .||| ..||. |  || |. | .|.| .| ||. | ||||. ||.||||||..|.||.||.||.||||||||.||||.|||||  ||..|| ||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RMMLIRGNHESRQITQVYGFYDECLRKY-GNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEG--
|. |.|||||||||||||||| |||||| ||. |||. ||.||||.|||.|| ...|||||||||. ..|||.|.|| .|||..| ..|||||||||   
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

-------NVG--WGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAPQE
       . |  .  |.||||| .| |  . | ..| .. | |||||..|||. .|..|. |||||||||||||| |.|||| |.... | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 34-312 2.3e-67 220.0 In-house 5-286 (290) alignment 
Range on Protein: 34-312
Range on HMM: 5-286/290.0
RHIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRM
 |..|    . ....|. ..  |..|||     .  . .|..| ||||||. .|.. |.  |  |. ..|||||.||||  |.|  |||. .| ||. ..
ehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkv

MLIRGNHESRQITQVYGFYDECLRKYgNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQ--EVPHDGPMCDLLWSDPEE--GN
 |.||||| |.. ..|||..|  ||  .. .||   .||. ||| | .. |..|.|||.|. | . . .. . . .     ..| . ||||.||..   .
hllrgnhevrkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkdd

VGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIF
       |.   .|| ..  ..... ...|| |||..  ||... |..|..||.||| |. .  |. ||... | |. .....
tialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_PPP5C_pd Subfamily PPP5C 35-317 1.1e-84 277.3 In-house 24-311 (322) alignment 
Range on Protein: 35-317
Range on HMM: 24-311/322.0
HIEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVID----SPVTICGDIHGQFYDLMELFKVGG-PVPNTNYLFLGDFVDRGFYSVETFLLLLALKARY
 .|..   . . .. . .. ..|.|.| ..  .  |.    . .|.|||||||||||...|.. | | ..  ||| ||||||| .|||. |.||..|  |
llelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfklly

PDRMMLIRGNHESRQITQVYGFYDECLRKYGNaSVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSP-SISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEg
|... | |||||| .. ..||| .|.  || .  | .  ||||..| || ||. ||. |||||      |.|..| ||| .. |..| ...||||||.| 
PnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.

NVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILEL-DENLNKEFTIFEAAPQ
. | . | || |  || | .| |...|...|| |.|.. .|||. . . |..||.|||||| . || .|...| ...|. .|. ||| . 
anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeaveh
subfamily_PPP3C_pd Subfamily PPP3C 36-305 8.8e-87 284.7 In-house 32-313 (452) alignment 
Range on Protein: 36-305
Range on HMM: 32-313/452.0
IEKLMRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMML
 |....   . |...  .  .| ..| .| ..  ...|.|..||||||||||..||.|||   .|.||||||.|||| .|.|. | |.|||  ||....|
kehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfl

IRGNHESRQITQVYGFYDECLRKYGNaSVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVG----
.|||||.| .|. . | .||  ||.. .|...|.| || | |||..... .|||||||| |...|.|. .|| .|.|. ||.|||||||| |        
lrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekte

---WGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFN------EKVLTVWSAPNYCYRCGNVAAILELDENL
      |.||  |...  |. .| ..| .  | |||.   .||. . .        ..|..|||||.    | ||.|....| 
ekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 37-313 3.9e-78 255.7 In-house 16-293 (297) alignment 
Range on Protein: 37-313
Range on HMM: 16-293/297.0
EKLMrCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLI
|||. ...|.|. |  |   | ...  . ..  ...|. .|||||||| ||. ||. ||  | .|||||||.|||| .|.|| .|||| | ..|  ..|.
ekll.skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfll

RGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSP---SISTMDQIRVIDRKQEVpHDGPMCDLLWSDPEEGNVGWG
|||||   . .|||||.|| ..|    ..    .||..| |. .|  |..|.||||||      |.| .| |.| .|  ... ..||||.||  |  |. 
rgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfm

LSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFE
   ||||  || ||    |    .||.|||||.| .||..    |..|..||| || .  |.||..  ||.|.  | |. 
enqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 39-315 1.9e-86 282.7 In-house 2-275 (280) alignment 
Range on Protein: 39-315
Range on HMM: 2-275/280.0
LMRCelIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRG
|..|  | | |....  | ..||. .  .  .|.||..|||.|||. ||. ||.  .  |..|||||||.|||| . .|  ||||| |.|||......||
llac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrg

NHESRQITQVYGFYDECLRKYGNAsVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRG
|||  .| . |||.||. |.| .| ....  |..| | |.|.. |...|.|||||. . ..|... . |  . ...    ||||.|||.   ||. ..||
nhevisinrkygfkdevkrrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrg

AGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAA
. ..|||.  | ..|   .|||.| ||.| .||..  . |..||.|||.|.    | ||.| .||.|   | ..  |
vsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 40-313 2.7e-75 246.0 In-house 5-280 (287) alignment 
Range on Protein: 40-313
Range on HMM: 5-280/287.0
MRCELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGN
   . ....|. ..  |..|||     .  ...|.||.||||||. ||. .|.  |  |...||||||.||||  |.|  |||..|| .|| .. |.|||
gvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGn

HESRQITQVYGFYDECLRKYGnASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQE--VPHDGPMCDLLWSDPEEGNVGWGLS-P
|| ..| ..|||..|  ||..  ...|.  .||..|.| | .. ...|.|||.|| . ..|... . . .     ..| . ||||.|||. . .  |   
hevkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnki

RGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFE
|.   .||      .... ..||| |||... |||.. |.....||.||| |. .  |..|.. ... |.  |. . 
raisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 42-311 1.8e-69 227.3 In-house 3-271 (280) alignment 
Range on Protein: 42-311
Range on HMM: 3-271/280.0
CELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHE
|.... ... ..      |. || |.   ..|. . |||| |. |.  || . | ||. . .||||.||||   .| ..||..|| || ||. |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNAsVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGY
.  . ..|||| ||  ||| . .|     .|. . ....|  .|.|.|||||| .  .| || | |  |    | . ||||||| .   ||  | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTI
.||    .  |..  .||| ||||.| .||.     ...||.| |||| .  | ||.. |. ||.  |  
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 43-318 1.1e-85 280.5 In-house 22-297 (299) alignment 
Range on Protein: 43-318
Range on HMM: 22-297/299.0
ELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHES
. . ||...|||| |....|..  .  ...|. .|||||||. ||. .|.. |  |..|.|||||.||||   .|.  |||. | .||.|....||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYL
  | .|||||.|| ..|  . .|    . |... |. .| ....|.|||||| ..|.||.| . | |. |      ||||.||..  ..|    ||  |.
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAPQE
|| |  .  ... ..||..||||.| .||..  . |..|..||| || .  | |||...||||   |.... .|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 43-313 5e-84 275.1 In-house 6-281 (284) alignment 
Range on Protein: 43-313
Range on HMM: 6-281/284.0
ELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGG-P-----VPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLI
.|. |...  || .|||.. .|   . |..||.|.||||||| ||. |... | |       ...||||||.|||| .|.|  .||.|.| ..||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECLRKYGNAsVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSP
||||||| . . |||| || ..| .| ...     |  . |.||.. |..|.|||.|  .  ..|.  ..|  ..|  | ..|| |.|||.  .|.  ||
rgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFE
|||| .|||.| | |...  .||. ||||.||.||..  . |..|..||| || .  |.||.|..||.|   ||...
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 43-95 7e-13 41.4 In-house 7-59 (317) alignment 
Range on Protein: 43-95
Range on HMM: 7-59/317.0
ELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGG
.|. |...  || .|||.. .|     ...||||.||||||| ||. |... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 43-95 6e-08 25.1 In-house 9-61 (339) alignment 
Range on Protein: 43-95
Range on HMM: 9-61/339.0
ELIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGG
.|..  ..  || .|||..  |  .  ...|. . ||||||| ||. .. . |
dlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_PPP1C_pd Subfamily PPP1C 44-315 5.6e-108 353.4 In-house 9-279 (282) alignment 
Range on Protein: 44-315
Range on HMM: 9-279/282.0
LIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESR
 . |.....|..|||||| ..  .  .. ||.|.||||||..||. ||. .|  |..|||||||.||||  |.|| .||||.| .||... |.|||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGNAsVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLF
.|...||||||| |.|..  .||. |.||..| |||..| |..||||||||... ..||| | |  |||..| .||||||||.. ..||. . ||  . |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAA
|.|. ..|.. | .|||.||||.| .||... .....||.|||||| . .| .|.|..||.|  .|.|. .|
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 44-312 2.9e-74 243.0 In-house 2-271 (284) alignment 
Range on Protein: 44-312
Range on HMM: 2-271/284.0
LIAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESR
||. .||.||  .| .|. ..  .  ..||. ||||||||| ||. ||   |    .|||||||.|||| . .|| |||.| |  .|......|||||  
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

QITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPM-CDLLWSDPEEGNVGWGLSPRGAGYL
 | ..||||.|| |.| . ||..    ||  . |.|..  ...|.|||.|  .  . |.| | |  . |    .  |.||||| . . ||    ||  |.
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyv

FGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIF
||.|| . . .   .||. ||||.| .||..  | ...|..||| || .  | ||.. ...||   | ..
fgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
PPP_3 45-313 2.2e-122 400.3 In-house 2-270 (271) alignment 
Range on Protein: 45-313
Range on HMM: 2-270/271.0
IAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQ
. |...|.|. |..||| .| |.. |..|||.|||||||..||.||||.|||.|.|.||||||.|||| .|.|..||||||| .||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFG
|..||||..|.|.|.|...|.|...|||..|.|||.||.||..|||||||||...|||. ..||.|||..|...|||.|...| . |.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFE
.|....|.|.| ..||.|||.|..|||. ....||.||.||||||.|..|..|||.|.|.|..||...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 45-313 1.2e-79 260.5 In-house 8-275 (281) alignment 
Range on Protein: 45-313
Range on HMM: 8-275/281.0
IAEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQ
.........  ... |..|| ..  ||.|... ||.|.|| || .||.. | ||.. ..||||.||||  |.|...||..|| ||.||..|.|||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECLRKYGNaSVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFG
. ..|||| ||  |||   .|    . |. | ..| |. .| |.|||||| . ..|..| . .  . .. | . ||||.||..   .|  | ||....||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

ADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFE
 .  .  | . .|.|| ||||.|..||.     |..||.|.||||    | ||.| .||.|. ..  . 
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalv
PPP_1 46-300 2.5e-113 370.7 In-house 2-263 (264) alignment 
Range on Protein: 46-300
Range on HMM: 2-263/264.0
AEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQI
.|. ...|. |..|.| .| |.. .....|.||||||||.||..|||||||.|.||||||||.|||| .|||..||||||| .||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLL-------WSDPEEGNVGWGLSPRG
|.||||..|.|.|.......| .|.|||.|.|||.||.|...|||||||.....|||| ..||.|||..|..||||       .||..| . ..  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILE
||||||.|....|...|...||.|||....|||......||.|..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 46-314 3.4e-108 353.8 In-house 2-269 (271) alignment 
Range on Protein: 46-314
Range on HMM: 2-269/271.0
AEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQI
....|..|. ...||| .| |.  ...|||..||||||..||..|.. .|..|...|.||||.|||| .|.|. |||.||| .||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFGA
...|||..|. ||| ...... ..|.|..|.|||..| |..|.||||||.....|.|| ..| .| |..|...||||||||. . |.  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEA
|| | |...| ..||.|||..|.|||.. ...|..|..||||||....|.||.|....||. ..  ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPZ_pd Subfamily PPZ 46-312 3.2e-80 262.8 In-house 26-291 (300) alignment 
Range on Protein: 46-312
Range on HMM: 26-291/300.0
AEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQI
 ....  .| ||||..  . ..  .  .| | ||.|||. ||. ||   |  | .|||||||.||||  |.|| ||||. | .||. ..|.|||||  ..
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

TQVYGFYDECLRKyGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFGA
|.|||||||| |.  |  .||   . |. | |||.. ||.||||||||| . .||.|| . |  .||  | . ||||||| . .  |    ||  | .  
trvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynk

DASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIF
 | . | .  |.||.|||| .| .||..  .  ..||.||||||    |  |.. . | |   | ..
vainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfell
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 46-306 1.2e-55 181.8 In-house 7-291 (302) alignment 
Range on Protein: 46-306
Range on HMM: 7-291/302.0
AEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKV-----------GGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMM
 .... .|. .  | | .| ..  | .|||| ||||||| ||. ...                 .  ..||||.||||  |.|   |..|||  || . .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LIRGNHESRQITQVYGFYDECLRKYGNAS---VWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRK-QEVPHDGPMCDLLWSDPEEGNV
|.|||||.. |   ||| .|   ..|..    .|..  ||| .. |||..  |..|||||.|| ......|. |.|  .|| .|    |||..|| ....
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

GWGLS---------PRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLN
    |          ||  ..|   | . .|.  ...|| |||| . ||.|.. ..|.||..|||.|     |  |.|..| | .
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 46-305 1.9e-55 181.2 In-house 8-291 (302) alignment 
Range on Protein: 46-305
Range on HMM: 8-291/302.0
AEQDVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKV-----------GGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMM
 .... .|. .  | | .| ..  | .|||| ||||||| ||. ...                 .  ..||||.||||  |.|   |..|||  || . .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LIRGNHESRQITQVYGFYDECLRKYGNAS---VWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRK-QEVPHDGPMCDLLWSDPEEGNV
|.|||||.. |   ||| .|   ..|..    .|..  ||| .. |||..  |..|||||.|| ......|. |.|  .|| .|    |||..|| ....
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

GWGLS---------PRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENL
    |          ||  ..|   | . .|.  ...|| |||| . ||.|.. ..|.||..|||.|     |  |.|..| | 
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 49-312 2e-63 207.4 In-house 24-289 (307) alignment 
Range on Protein: 49-312
Range on HMM: 24-289/307.0
DVKTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQV
... .  .|. |.. |  .  || |. . ||.|||| ||...| . |  |.| |.| ||.||||. |.|. |||.. |  ||. ..|.|||||  .. . 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECLRKYGN--ASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFGAD
||||.||.    .    .|     .|. | ..|.|  |..|.||||||... .|..|   .    |  | . |.||.||.   . |  | ||.|. ||..
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

ASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIF
     |   ||.|| ||||....||      |..|..||| ||    |  ..| .|| |  .   |
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvaf
subfamily_PPPLV_pd Subfamily PPPLV 51-299 2.6e-57 187.3 In-house 3-274 (290) alignment 
Range on Protein: 51-299
Range on HMM: 3-274/290.0
KTLCAKAREILAEEGNVQVIDSPVTICGDIHGQFYDLM----ELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQIT
 .|| .| .|||.| ..  ..||. . ||.||.. ||.     |...|  .  ...|||||.|||| .|||    |||||  || ...|.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNA--SVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDR----KQEVPHDGPM-CDLLWSDPEEGN----------
. . .. |.  |.|.   .||.  ..|||.| |||||| ||||||.|.  .| |  .|  |.      ..  .  |.  |.|||||.|..          
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-VGWG-LSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAIL
  |.   . || |..|..|| ..| . |... . |||.   .|..   . ..|||.|. .||    . | ||
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalil
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 70-310 1.1e-57 188.7 In-house 5-251 (263) alignment 
Range on Protein: 70-310
Range on HMM: 5-251/263.0
IDSPVTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGN----ASVW
...|. |||| |||. ||. .|.  |   .|.||||||.|||| .|.|  .||..||   | .| |.||||| . | . |||. |  ...       ||.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPM-CDLLWSDPEEGNVGWGLS-PRGAGYLFGADASKTFCETNGVDLICRA
.|  .|| |. |.|..  ...|.|||.|| . ..|.|| |    |  .  |. |||||.|||.   |.     |    .||      .|.   .||| ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFT
||.|  || .  . ...||.||  |     | ||.. ... |.  | 
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfv
subfamily_YNL217W_pd Subfamily YNL217W 72-146 3.9e-07 22.8 In-house 10-80 (235) alignment 
Range on Protein: 72-146
Range on HMM: 10-80/235.0
SPVTICGDIHGQFYDLMELFK--VGGPVPNTNYLFLGDFVDRGFYSVETFLLLlalkarYPDRMMLIRGNHESRQIT
  . . ||.|| . .|.||..  .||  .|   ...||....|  |||.  ..        |    ..||||   . 
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
Metallophos Calcineurin-like phosphoesterase 73-266 1.5e-48 158.8 Pfam-A 2-198 (200) alignment 
Range on Protein: 73-266
Range on HMM: 2-198/200.0
PVTICGDIHGQFYDL----MELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLL--LALKARYPDRMMLIRGNHESRQITQVYGFYDECL----------
.....||.||...||    ..|.|.... .....|||||.|||| .| ||. ||  |.|| ..|.. .|.||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMDQIrvidrkqevphdgpmcdllwsdpeegnvgwg
                       ..... |.. .. |.|..|.|.| .|||....||.||.|  . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

lsprgAGYLFGADASKTFCETNGVDLICRAHQL
     ...||| ||   ..| .||||..|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
PPP_2 74-266 2.7e-83 271.5 In-house 1-197 (198) alignment 
Range on Protein: 74-266
Range on HMM: 1-197/198.0
VTICGDIHGQFYDLMELFKVGGPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEVFD
||.|||.|||..||..|||.|.|.|...||||||.|||| .|.|..||||||| .||....|.||||||.....||||..|.|.|.|...|.|...|||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVPHDGPMCDLL----WSDPEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQL
.|.|||.||.||..||||||..|...|||. ..||.|.|..|...|||    .|||.| . ..  | ||||.|||.|......|.| ..||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 74-266 4.1e-78 254.9 In-house 1-196 (197) alignment 
Range on Protein: 74-266
Range on HMM: 1-196/197.0
VTICGDIHGQFYDL-MELFKVG-GPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKyGNASVWKHCTEV
||..||||||..|| ..|.|.|  | ....|.||||.|||| .|.|..||||||| .||....|.||||||......|||..|.|.|  .....| ...|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVP-HDGPMCDL-LWSDPEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQL
||.|.|||.||.||..||||||......|.|. |.||.|.| ... ..|| |||||.| . |.  | ||||.|||.|. ..|.|.|...||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 74-266 4.3e-77 251.6 In-house 1-198 (199) alignment 
Range on Protein: 74-266
Range on HMM: 1-198/199.0
VTICGDIHGQFYDL-MELFKVG-GPVPNTNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGNASVWKHCTEV
||.|||.|||..|| ..||| |  | ....|.||||.|||| .|.|..||||||| .||....|.|||||..|....|||..|.|.||......| ...|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLAAVIDGKVFCVHGGLSPSISTMDQIRVIDRKQEVP-HDGPMCDL-LWSDPEEGNVG-WGLSPRGAGYLFGADASKTFCETNGVDLICRAHQL
||.|.|||.||.||..|||||||.| ...... |.||.|.| ..| ..|| |||||..   | .  | ||||.||| |. ..|.|.|...||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 100-313 5e-72 235.7 In-house 101-313 (317) alignment 
Range on Protein: 100-313
Range on HMM: 101-313/317.0
TNYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYGnASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTM
 .||||||.|||| .|.|  .||.||| .|||...|.||||||| . . |||| |. ..|  |....    .|  | |.||.. |..|.|||.| ..  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys.aalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAIL
.|. ...|  ..|  | ..|| |.||..   |.  |.|||| .|||.| | |...  .||. ||||.|..||..  . |..|..|||.|| .  |.||.|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDENLNKEFTIFE
..|..|.  .....
svdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 101-314 5.5e-56 183.1 In-house 121-333 (339) alignment 
Range on Protein: 101-314
Range on HMM: 121-333/339.0
NYLFLGDFVDRGFYSVETFLLLLALKARYPDRMMLIRGNHESRQITQVYGFYDECLRKYgNASVWKHCTEVFDYLSLAAVIDGKVFCVHGGLSPSISTMD
 ||||||.|||| .|.|  .|| |||  ||||. |.||||||| .   |||| |   .| .| ...   ..|. . ..|||.  ..|.|||.|  .....
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRVIDRKQEVPHDGPMCDLLWSDPEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILE
|. |. |  |.|  | . || |.||.  . |.  | ||| ..||  | ..| .   .... | ||.| .||..    ...|..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDENLNKEFTIFEA
.|..|.    .|  
idkklkisinvfrp
subfamily_PPP7C_pd Subfamily PPP7C 217-317 1.1e-18 60.1 In-house 237-337 (383) alignment 
Range on Protein: 217-317
Range on HMM: 237-337/383.0
MCDLLWSDPEEGNVGWGLSPRGAGYLFGADASKTFCETNGVDLICRAHQLVMEGYKWHFNEKVLTVWSAPNYCYRCGNVAAILELDENLNKEFTIFEAAP
. |.|||||.. .  .  . ||.|  ||.| .| . .  ...|. |.|.  .|||..  ..||||..|| ||     |  | . | ..|. ..  . |. 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask

Q
.
a