Gene pph-4.2 in Caenorhabditis elegans

Synonym: CELE_Y49E10.3, pph-4.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP153_AA protein Get Run
CeleP153_AA_10-305 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 11-305 6.6e-117 383.9 In-house 24-326 (473) alignment 
Range on Protein: 11-305
Range on HMM: 24-326/473.0
QLGPNDLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLL
 ||. |||. ||. ....|. |....... ...||| .| |.. .. .....||||||..||..|..  | ||.....||||.||||..|.|.. ||. |
llglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllal

KCRYPDRITLIRGNHESRQITQVYGFYDECVRKYgSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDP
|..||....|.|||||.|.....|||.||. .|| . ...... | ...| |||||.||...|||||||.. .||||| ..| .|.|..|...|||||||
kikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP

eEGCSG--------WGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKR------VVTVWSAPNYCYRCGNVAAIMEVTEeniDSdPV
 .  .|        .| |||||||||| ||.| |...|.. .|.|.|. |.|||.|.|...      ..||.||||||.|.|| ||.....|   |  . 
.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvide...dl.is

FEVFEAATV
| .|... .
fiqfdpsph
0049330 Metallo-dependent phosphatases 12-293 1.9e-109 358.4 In-house 12-292 (309) alignment 
Range on Protein: 12-293
Range on HMM: 12-292/309.0
LGPNDLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLK
|  ..||..||. ... |. | ... .. |..|||..| |.. .. .....||||||..||..|..  | ||.....||||.||||..|.|.. ||. ||
lilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalk

CRYPDRITLIRGNHESRQITQVYGFYDECVRKYGsGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPE
..|||...|.|||||.|.....|||.||..||||  ..|..... ...| |||||.||..||||||||.. .||||| |.| .|.|..|..|||||||| 
llypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdpl

EGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENIDS
. ..|.. .|||.|..|| .| | |.. |.. .|.|.|..|..||. .| ....||.||||||.|.||..|..|..|.   |
piregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvis
0053225 Metallo-dependent phosphatases 14-289 1.1e-103 339.6 In-house 6-280 (293) alignment 
Range on Protein: 14-289
Range on HMM: 6-280/293.0
PNDLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCR
  .||..||. ... |. |.... .. ...|||..| |.. .. .....|||||...||..|..  | ||.....||||.||||..|.|.. ||. ||..
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPDRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEeG
|||...|.|||||.......|||.||..||||. ..|..... ...| |||.|.||...|||||||.. .||||| ..| ...|.||...|||||||   
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.l

CSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEE
 |||..|.||.|..|| .| . |...|.. .|.|.||.|..||. .| ...|||.|||||..|.||..|.... |.
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg
subfamily_PPP4C_pd Subfamily PPP4C 15-305 5.3e-168 550.5 In-house 1-287 (288) alignment 
Range on Protein: 15-305
Range on HMM: 1-287/288.0
NDLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRY
.|||||||  .|||||.|..||..|||.||||.||.||| .|.|||.||||||||.||.|||.|||. |.||||||||.||||..|||||.||. ||.||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGC
||||||||||||||||||||||||||.||||| .||..|||.||||||||.||||.|||||||||||.|||.||..|||.|||||||.|||||||||. .
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

sGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVtEENIDSDpvFEVFEAATV
 ||..|||||||||| |..| |.|.||.  ||||||||||||||||...|.||||||||||||||||||.|. .|..|.|  |..||||..
.gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailel.deeldkd..fkifeaaaa
subfamily_PPP2C_pd Subfamily PPP2C 15-302 4e-143 468.9 In-house 2-285 (290) alignment 
Range on Protein: 15-302
Range on HMM: 2-285/290.0
NDLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRY
.|||..||  ..|. . |..||..| |..||| .|.||| . .|||.|||.|||||||.|||..||. |.|||||||||||||| ||||  ||. || ||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEeGC
..|||..|||||||||||||||||||.||||. .|||. |..||||.|.|..|...||.|||||||| |||.|| |||  |||||||.||||||||.   
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.dr

SGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENidsDPVFEVFEA
.||||||||||| || | .| | ..|..  | ||||||||||.  . ..|||..||||||||||| |||.|. ..    .  |  |..
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddkl...kysflqfdp
subfamily_PPP6C_pd Subfamily PPP6C 16-298 2.7e-138 452.9 In-house 1-282 (290) alignment 
Range on Protein: 16-298
Range on HMM: 1-282/290.0
DLDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYP
.||. ||.| .|. . |...| .|..| ..|.||.||| . .|||.||||||||.||.|||| ||. |.|.|.||||.||||| |.||| .|. || .||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEgCS
|||||.|||||||||||||||||||..|||....||.||..|| |..||.||....|||||||| . |||||||..| .|.||.|..|||.|||||.  .
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdped.ve

GWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENIDSDPVFE
 | .||||||||||   .. |...|..  ||||||||.||.| .| ...|||||||||||||||||.|... ...  .  .|.
twavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 17-304 2.2e-127 417.5 In-house 1-297 (300) alignment 
Range on Protein: 17-304
Range on HMM: 1-297/300.0
LDRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPD
||. .|   ..||. |. ||... |..|.|..|.||. | .|||. ||.||||.|..|.|..||  |.|||||||||||||. |||| .||..|| ||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYDECVRKY-GSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEE---
||||.|||||||||||||||| ||.||| |  .|||. |||||||.|||.|| ...|||||||||. ..|||.||||  |||.|| ..|||||||||   
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------GCSG--WGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENidsDPVFEVFEAAT
        .|  . .|.||||| .| | .| | .|||. || |||||..|||...| ... |||||||||||||| |.|.|. | .   .  |.|.|.| 
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd...eryfnvyeeap
subfamily_PPP7C_pd Subfamily PPP7C 18-193 6.5e-36 116.8 In-house 21-202 (383) alignment 
Range on Protein: 18-193
Range on HMM: 21-202/383.0
DRQIEIAMRCELICETQVKSICAKVREILIEEANVQVIDT----PVTICGDIHGQFHDLMELFRVGGSPP-NTNYLFLGDYVDRGYNSVETFILLMLLKC
.. ||   . .|.    |  |  . ...| .  |.. . |     ||.|||.||.. ||. ..   | |  . .|.| ||.|||| .|||  ..|. |  
eklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalll

RYPDRITLIRGNHESRQITQVYGFYDECVRKY--GSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPsIATLDQIRVLDRK
 ||  . | |||||   .   |||  |   ||   . .. .   ..| .| ||..|| |.. ||||.|  .. |. .  ..|.
vypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisd.ktdlelldkiers
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 22-291 5.3e-93 304.3 In-house 16-285 (298) alignment 
Range on Protein: 22-291
Range on HMM: 16-285/298.0
EIAMRCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLI
. .  .. | |..|.........|. . . .  .|.|...|||||||. ||. ||  .| ||..|||||||||||| ...|. .||.  | .||... |.
sekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffll

RGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISP
|||||  .| .|||||.|| |.| | .....  ..|. | |.|.| |...|.|||||. . .|||.| | | .. ..|    ||||.|||.  .||  . 
rGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaens

RGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENI
||... || |. . ..|. |   ..||||.| .||..   |..||..|||.|| .  | ||.|.| |. .
rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 26-293 1.7e-83 273.0 In-house 4-268 (280) alignment 
Range on Protein: 26-293
Range on HMM: 4-268/280.0
RCelICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNH
.|  | |......  |...||  .| .  .|.||..|||.|||. ||. ||   . ||..||||||||||||   .|  .||.  | |||... ..||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECVRKYgSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAG
|  .| . |||.||. |.| | .....  |..| | |.|.. |...|.|||||. . .||... | | .. ..|    ||||.|||.  .||. ..||. 
evisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENIDS
..|| .    ..|  |   |.| ||.| .||..   |..|||.|||.|.    | ||.. | |. | |
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivs
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 26-289 2e-74 243.5 In-house 19-284 (297) alignment 
Range on Protein: 26-289
Range on HMM: 19-284/297.0
RCELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNH
 ...| | .|  .     ...  . ..  ...|. .|||||||| ||. ||. || || .||||||||||||  |.|| .||.  | ..|  . |.||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPS---IATLDQIRVLDRKIEVpHEGPMCDLLWSDPEEGCSGWGISPR
|   . .|||||.|| ..| | ...    ..|..| |. .|  |..|.||||||      ||| .| ..|  |  .|. ..||||.||  | ||.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEE
|||  || ||    | . ..  .|||||.| .||..   ...||..||| || .  |.||.| . |.
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdek
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 27-285 4.7e-70 229.2 In-house 3-260 (280) alignment 
Range on Protein: 27-285
Range on HMM: 3-260/280.0
CELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHE
|...   .. .|   |  |..||.|.   ..|. . |||| |..|.  || . |  |. . .||||||||| . .| .|||. || || ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECVRKYGSGQVWKHcTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGY
.  . ..|||| ||  ||| |  |     .|. . ....|  ...|.|||||| .  || || . | .|    | . ||||||| .   ||  | ||  |
tpsvnkiygfyvecqykygvglwwdf.qscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIME
.||    |  |.. .   | ||||.| .||..   .|..||.| |||| .  | ||.. 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvc
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 27-82 5e-09 28.7 In-house 8-63 (339) alignment 
Range on Protein: 27-82
Range on HMM: 8-63/339.0
CELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSP
 .|.| ...  .| . ||..  |  .  ...|. . ||||||| ||. .. . | |
ldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-291 3.6e-80 262.4 In-house 6-274 (284) alignment 
Range on Protein: 28-291
Range on HMM: 6-274/284.0
ELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSP------PNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLI
.|. |...  .| . ||.. .|   . |..||.|.||||||| ||. |. . | |       ...|||||||||||  |.|   ||. .| ..||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECVRKYgSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISP
||||||| . . |||| ||...| | ....     |  . |.||.. |..|.|||.|  .  |.|.  |.| |..|  | ..|| |.|||.  .|.  ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENI
|||| .|| .| . |... ..  . ||||.||.||..   ...||..||| || .  |.||...| || .
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-82 2.1e-13 43.1 In-house 7-61 (317) alignment 
Range on Protein: 28-82
Range on HMM: 7-61/317.0
ELICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSP
.|..|...  .| . ||.. .|     ...||||.|||||||.||. |. . | |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_PPP1C_pd Subfamily PPP1C 30-291 5.3e-104 340.4 In-house 10-270 (282) alignment 
Range on Protein: 30-291
Range on HMM: 10-270/282.0
ICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQ
. |........| ||||.... .  .. ||.|.||||||..||. ||  .|.||..|||||||||||| .|.|| .||. .|..||... |.|||||| .
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

ITQVYGFYDECVRKYGSGqVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFG
|...||||||| |.|..  .||. |..|..| |||..| |..||||||||..  |.||| . | .|||..| .||||||||..   ||. . ||  . ||
inriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfg

GDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENI
 |. | |...||.  |.||||.| .||... ....|||.|||||| . .| .|...|.|| .
kdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeell
subfamily_PPP3C_pd Subfamily PPP3C 30-291 5.3e-87 285.5 In-house 41-314 (452) alignment 
Range on Protein: 30-291
Range on HMM: 41-314/452.0
ICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQ
. |...  |  .. ..| .| ..  ...|.|..|||||||.||..|| |||.| .|.|||||||||||| |.|. . |. ||. ||... |.|||||.| 
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

ITQVYGFYDECVRKYGSgQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWG-------ISPR
.|. . | .||  ||.  .|...|.| || | |||..... .|||||||| | .||.|. |||  |.|. ||.|||||||| |  .           |.|
lteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFR------KRVVTVWSAPNYCYRCGNVAAIMEVTEENI
|  |...  |.  | ..||.| | |||.   .||. . .        ..|..|||||.    | ||.... ....
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 30-292 4.2e-82 268.7 In-house 24-286 (299) alignment 
Range on Protein: 30-292
Range on HMM: 24-286/299.0
ICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQ
. | .....||  .......| .  ...|. .|||||||. ||. .| . | ||..|.|||||||||| . .|. .||.  | .||.|. ..|||||   
vkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpa

ITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFG
| .|||||.|| ..| | ..|    . |... |. .| ....|.|||||| . ||||.| | |  . |      ||||.||..   .|    ||  |.||
inrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfg

GDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENID
 |  .  ... |   ..||||.| .||..   |..||..||| || .  | ||||.| |. . 
qdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvc
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 30-290 1.7e-67 220.8 In-house 3-264 (284) alignment 
Range on Protein: 30-290
Range on HMM: 3-264/284.0
ICETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQ
|   .|...  .. .|. ..  .  ...|. ||||||||| ||. ||   | |  .||||||||||||   .|| .||.  |  .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPM-CDLLWSDPEEGCSGWGISPRGAGYLF
| ..||||.|| |.|    |..    .|  . |.|..  ...|.|||.|  .  . |.| . | .. |    .  |.||||| .   ||    ||  |.|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEEN
| ||   . .  .   . ||||.| .||..   .|.||..||| || .  | ||.| | .. 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknl
PPP_3 31-294 1.4e-118 387.8 In-house 3-266 (271) alignment 
Range on Protein: 31-294
Range on HMM: 3-266/271.0
CETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQI
 |...|... |..||| .|.|.. |..|||.|||||||..||.|||..||..|.|.|||||||||||..|.|...||. ||..||....|.|||||||||
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

TQVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGG
..||||..|...|.|. .|.|...|.|..|.|||.||.|...||||||||| .||||. |.||||||.||...|||.|...|  .|.. |.||||.||| 
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENIDSD
|..| |.|.|..  |.|||.|..|||.......||||.||||||.|..|..||....|..  . 
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsef
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 31-288 8e-78 254.5 In-house 9-265 (281) alignment 
Range on Protein: 31-288
Range on HMM: 9-265/281.0
CETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQI
 . .....  .|. |. || ..  ||.|... ||.|.||.|| .|| . | .|.. ..||||||||| .|.|..|||. || ||.||| |.|||||  ..
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

TQVYGFYDECVRKYGSGqVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGG
 ..|||| ||| ||| . .|    . |. | ..| |. .  |.|||||| . .||..|   . |. .. | . ||||.||..   .|  | ||....|| 
nkiygfyvecvtkyGee.lwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

DAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTE
.  .  | . .   | ||||.|..||..   ....||.|.||||    | ||.. | |
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvde
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 31-288 4e-74 242.1 In-house 11-270 (287) alignment 
Range on Protein: 31-288
Range on HMM: 11-270/287.0
CETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQI
 .... ..  |..|||     .  ...|.||.||||||..||. .|   | .|...||||||||||| .|.|  .||. || .|| .. |.||||| ..|
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

TQVYGFYDECVRKYGsGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKI--EVPHEGPMCDLLWSDPEEGCSGWGIS-PRGAGYL
 ..|||..|  ||.. ....|.  ..|..|.| | .. ...|.|||.|| . .||... | .       .|| . ||||.|||. . .  .   |.   .
nklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTE
||    . .... |   | |||... |||.. | ||.|||.||| |. .  |..|.. |..
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-288 3.3e-66 216.2 In-house 17-277 (290) alignment 
Range on Protein: 31-288
Range on HMM: 17-277/290.0
CETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQI
 . .. .|  |..|||     .  . .|..| ||||||. .|.. |   | ||. ..|||||||||| .|.|  .||. .| ||. .. |.||||| |..
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

TQVYGFYDECVRKYGsGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRK--IEVPHEGPMCDLLWSDPEE-GCSGWGIS-PRGAGY
 ..|||..| .|| | ...||   ..|. ||| | .. |..|.|||.|. | . . .. | .       .|| . ||||.||..  .    .   |.   
nrlygfkeelarkrg.srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisv

LFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTE
.|| .. . ....  .  | |||..  ||... | |..|||.||| |. .  |. ||..|.|
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvse
PPP_1 32-286 1.8e-110 361.4 In-house 3-264 (264) alignment 
Range on Protein: 32-286
Range on HMM: 3-264/264.0
ETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQIT
|....... |..|.| .| |.. .....|.||||||||.||..||.|||..|.|||||||||||||..|||...||. || .||....|.||||||||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QVYGFYDECVRKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLL-------WSDPEEGCSGWGISPRGA
.||||..|...|..| ...| .|..||.|.|||.||.|...|||||||.. .||||| ..||.|||.||..||||       .||..|  ...  |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEV
||||| |..| |...|..  |.|||....|||.......|||..||.||.....| .|....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 32-289 8.9e-105 342.6 In-house 3-259 (271) alignment 
Range on Protein: 32-289
Range on HMM: 3-259/271.0
ETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQIT
. .|.... .|.||| .|.|.  ...|||..||||||..||..|.. .| ||...|.|||||||||..|.|. .||. || .||....| ||||||....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

QVYGFYDECVRKYgSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGGD
..|||..|. ||| . .... ..|.|..|.|||..| |..|.||||||.. .||.|| |.|  | |.||...||||||||.  .|. .| ||....|| |
kiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

AAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEE
|.. |...|.. .|.|||..|.|||.. ..|..||..||||||....|.||...| ..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkvekn
subfamily_PPZ_pd Subfamily PPZ 32-296 2.9e-79 259.7 In-house 27-290 (300) alignment 
Range on Protein: 32-296
Range on HMM: 27-290/300.0
ETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQIT
....  || | ||... . ..  .  .| | ||.|||. ||. ||   | || .|||||||||||| .|.|| .||.  | .||. . |.|||||  ..|
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvt

QVYGFYDECVRKYgSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGGD
.|||||||| |.    ..||   . |. | |||.. ||.||||||||| . ..|.|| . |  .||  | . ||||||| .    |    ||  | .   
rvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkv

AAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEENIDSDPV
| . | ..  |  .|||| .| .||..   . .|||.||||||    |  |.| |.|  . |  .
ainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfel
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 32-288 1.4e-52 171.7 In-house 8-288 (302) alignment 
Range on Protein: 32-288
Range on HMM: 8-288/302.0
ETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGS-----------PPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITL
.... ... .| | | .| ..  | .|||| |||||||.||. ..    |             .  ..|||||||||..|.|   |.. ||  || .  |
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

IRGNHESRQITQVYGFYDECVRKYGSGQ---VWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIE-VPHEGPMCDLLWSDPEEGCSG
.|||||.. |   ||| .| . ..|  .   .|..  |.| .. |||..  |..|||||.|| . .|..|. ..| .. | ..    |||..|| .. . 
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqll

WGIS---------PRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTE
  .|          ||  ..|   | . .|.. ..  | |||| . ||.|..  |...|..|||.|     |  |...|  
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 32-288 1.9e-52 171.3 In-house 9-289 (302) alignment 
Range on Protein: 32-288
Range on HMM: 9-289/302.0
ETQVKSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGS-----------PPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITL
.... ... .| | | .| ..  | .|||| |||||||.||. ..    |             .  ..|||||||||..|.|   |.. ||  || .  |
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

IRGNHESRQITQVYGFYDECVRKYGSGQ---VWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIE-VPHEGPMCDLLWSDPEEGCSG
.|||||.. |   ||| .| . ..|  .   .|..  |.| .. |||..  |..|||||.|| . .|..|. ..| .. | ..    |||..|| .. . 
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqll

WGIS---------PRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTE
  .|          ||  ..|   | . .|.. ..  | |||| . ||.|..  |...|..|||.|     |  |...|  
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_PPPLV_pd Subfamily PPPLV 36-292 1.2e-51 168.8 In-house 3-281 (290) alignment 
Range on Protein: 36-292
Range on HMM: 3-281/290.0
KSICAKVREILIEEANVQVIDTPVTICGDIHGQFHDLM----ELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQIT
 |.| .  .||..| ..  ...|. . ||.||...||.     |.|.|     ...||||||||||  |||    |. ||  || .. |.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECVRKYGSG--QVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQI---RVLDRKIEVPHEG-PM-CDLLWSDPEEGC----------
. . .. |.  |.|    .||.  ...||.| |||||| |.||||.|.  .| |  .|   . .  ... . .| |.  |.|||||.|.           
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

-SGWG-ISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRcGNVAAIMEVTEENID
  |.   . || |..|. || | | ..|.   . |||.   .|..|  . |..||.|. .||    | ||.. | .....
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkklr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 41-288 1.4e-61 201.4 In-house 31-280 (307) alignment 
Range on Protein: 41-288
Range on HMM: 31-280/307.0
KVREILIEEANVQVIDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDEC
. . |.  |  .  || |. . ||.|||| ||...| . | ||.| |.| |||||||  |.|. .||.  |  ||. | |.|||||  .. . ||||.||
eaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeec

VRKYG--SGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGGDAAELFCE
|        ..|      |. | ..|.|  |..|.||||||... ||..|   . |  |  | . |.||.||.     |  | ||.|. || .  .  | 
vtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvck

NNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTE
      | ||||....|| .   ....|..||| ||    |  ... | |
rlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvde
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 55-286 3e-55 180.7 In-house 5-242 (263) alignment 
Range on Protein: 55-286
Range on HMM: 5-242/263.0
IDTPVTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYGSGQ----VW
...|. |||| |||. ||. .|   |.  .|.|||||||||||  |.|  .||. ||   | .. |.||||| . | . |||. |  ...   .    |.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPM-CDLLWSDPEEGCSGWGIS-PRGAGYLFGGDAAELFCENNDFLRICRA
.|  ..| |. |.|..  ...|.|||.|| . .||.|| .   .|  .  |. |||||.|||. . |.     |    .||    . .|.  |   | ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEV
||.|  || .   .|..||.||  |     | ||.. |
hqvveygyaffadrrlitvfsasryqielcnyaavvvv
subfamily_YNL217W_pd Subfamily YNL217W 55-131 1.9e-07 23.8 In-house 8-80 (235) alignment 
Range on Protein: 55-131
Range on HMM: 8-80/235.0
IDTPVTICGDIHGQFHDLMELFR--VGGSPPNTNYLFLGDYVDRGYNSVETFILLmllkcrYPDRITLIRGNHESRQIT
    . . ||.|| . .|.||.   .||  .|   ...|| ...| .|||.  ..        |    ..||||   . 
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_PPP5C_pd Subfamily PPP5C 56-304 1.6e-78 257.0 In-house 64-310 (322) alignment 
Range on Protein: 56-304
Range on HMM: 64-310/322.0
DTPVTICGDIHGQFHDLMELFRVGGSPPNTN-YLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYgSGQVWKHCT
.. .|.||||||||.||...|.. |.| ..| ||| ||.||||  |||. ..|. .|  ||... | |||||| .. ..||| .|.  || . .| .  |
tkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlft

EIFDYLSLAAVIDGKLFCVHGGL-SPSIATLDQIRVLDRKIEVPHEGPMCDLLWSDPEEgCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVM
|.|..| || ||. |.. ||||| |   .|||..| .||  . |.|| ...||||||.|  .| . | || |  || | .. |...|..  | |.|.. .
evfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtkkflkennleliirshevke

EGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEEniDSDPVFEVFEAAT
|||...   ...||.|||||| . || .|.......  | .. |. ||| .
eGyevehdGklitvfsapnycdqmgnkgafitlrgd..dlklkfktfeave
Metallophos Calcineurin-like phosphoesterase 58-251 1.2e-45 149.3 Pfam-A 2-198 (200) alignment 
Range on Protein: 58-251
Range on HMM: 2-198/200.0
PVTICGDIHGQFHDL----MELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILL--MLLKCRYPDRITLIRGNHESRQITQVYGFYDECV----------
.....||.||...||    ..|............|||||.|||| .| ||. ||   .|| ..|... |.||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLDQIrvldrkievphegpmcdllwsdpeegcsgwg
                       .... . .. .. |.|..|.|.| .|||....||.||.|  . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

isprgAGYLFGGDAAELFCENNDFLRICRAHQL
     ...||| || | ..|...   ..|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
PPP_2 59-251 4.6e-81 264.2 In-house 1-197 (198) alignment 
Range on Protein: 59-251
Range on HMM: 1-197/198.0
VTICGDIHGQFHDLMELFRVGGSPPNTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEIFD
||.|||.|||..||..||..|...|...|||||||||||..|.|...||. ||..||....|.||||||.....||||..|...|.|. .|.|...|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVPHEGPMCDLL----WSDPEEGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQL
.|.|||.||.|...||||||..| .||||.  .||||.|.||...|||    .|||.|  ...  | ||||.||| |..| ..|.|..  |.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 59-251 6.7e-77 251.0 In-house 1-196 (197) alignment 
Range on Protein: 59-251
Range on HMM: 1-196/197.0
VTICGDIHGQFHDL-MELFRVGGSPP-NTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKyGSGQVWKHCTEI
||..||||||..|| ..|...|| |. ...|.|||||||||..|.|...||. ||..||....|.||||||......|||..|...|  . ...| ....
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVP-HEGPMCDL-LWSDPEEGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQL
||.|.|||.||.|...||||||... .||.|. ..||||.| .|. ..|| |||||.|  .|.  | ||||.||| |..| |.|.|..  |.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 59-251 8e-76 247.5 In-house 1-198 (199) alignment 
Range on Protein: 59-251
Range on HMM: 1-198/199.0
VTICGDIHGQFHDL-MELFRVGGSPP-NTNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYGSGQVWKHCTEI
||.|||.|||..|| ..||. || |. ...|.|||||||||..|.|...||. ||..||....|.|||||..|....|||..|...||.. ...| ....
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLAAVIDGKLFCVHGGLSPSIATLDQIRVLDRKIEVP-HEGPMCDL-LWSDPEEGCSG-WGISPRGAGYLFGGDAAELFCENNDFLRICRAHQL
||.|.|||.||.|...|||||||.| ...... ..||||.| ..| ..|| |||||.. ..| .  | ||||.||| |..| |.|.|..  |.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 85-289 1.9e-68 224.0 In-house 101-304 (317) alignment 
Range on Protein: 85-289
Range on HMM: 101-304/317.0
TNYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYgSGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATL
 .|||||||||||  |.|  |||. || .|||...|.||||||| . . |||| |. ..| | ....    .|  | |.||.. |..|.|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIM
.|. .|.| ...|  | ..|| |.||..  .|.  |.|||| .|| .| . |... |.  . ||||.|..||..   ...||..|||.|| .  |.||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

EVTEE
.| ..
svdkk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 86-288 1e-55 182.2 In-house 121-322 (339) alignment 
Range on Protein: 86-288
Range on HMM: 121-322/339.0
NYLFLGDYVDRGYNSVETFILLMLLKCRYPDRITLIRGNHESRQITQVYGFYDECVRKYGsGQVWKHCTEIFDYLSLAAVIDGKLFCVHGGLSPSIATLD
 |||||||||||  |.|  |||  ||  ||||| |.||||||| .   |||| |   .|   |...   ..|. . ..|||.  ..|.|||.|  .....
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd.aqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRVLDRKIEVPHEGPMCDLLWSDPEEGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIME
|. |. | .|.|  | . || |.||.    |.  | ||| ..||  |   | .. |.  . | ||.| .||..   .|.||..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VTE
. .
idk
subfamily_PPP7C_pd Subfamily PPP7C 202-289 4.8e-15 48.2 In-house 237-324 (383) alignment 
Range on Protein: 202-289
Range on HMM: 237-324/383.0
MCDLLWSDPEEGCSGWGISPRGAGYLFGGDAAELFCENNDFLRICRAHQLVMEGYKLHFRKRVVTVWSAPNYCYRCGNVAAIMEVTEE
. |.|||||..    .  . ||.|  || | .. . .. ..  . |.|.  .|||..   |.|.|..|| ||     |  | . ....
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkd