Synonym: CELE_Y105C5B.3, CELE_Y105C5B.3
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| PhoD | PhoD-like phosphatase | 79-167 | 5.8e-11 | 33.0 | Pfam-A | 58-148 (453) | alignment | ||
Range on Protein: 79-167
Range on HMM: 58-148/453.0
KTMRYTHRATMQNLVPGQVYYYQVGS--SQAMSSIFHFRQPdPSQPLRAAIFGDLSIIKGQQS-IDQLIEATKQNQLDVIIHIGDLAYDLHD
... || ......| ||| |.|.. . ... | . ..| |.. ... .. .| ...| . . |......||...|.|| | ..
serdytvkvevtgLepgqeyfYrfraeegesespvGrtrTl.peaaveslrlavvSCsnyeqGyfnayrelaekedlDfvlhlGDyiYeyge
|
|||||||||
| Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 124-345 | 6.4e-12 | 37.7 | Pfam-A | 2-138 (156) | alignment | ||
Range on Protein: 124-345
Range on HMM: 2-138/156.0
RAAIFGDLSIikGQQSIDQLIEATkqNQLDVIIHIGDLAYdlHdengatgddyMNAIEPFAAYvPYMVFAGNHEVDGDFNHIKNRFtmprngvydnnlfw
..||..|| . .......|. .. |.|.| ||| . . .| .... | . |||. . .... ..
kiaiiSDlHg..nldaleavledi..kevdlilhaGDlve..p..........eevvelledi.pvlavrGnhDeaelpkelavel..............
sftygfvhiiainseyyaeemsneakaqyqwLREDLAQNTKKWTIVMFHRpwycsskKKKGCNDDQDIlsregdkkkfpgLEELLNQYKVDMVLYGHKHT
| . .| . ........|. .. ....... |.|||.....|.|..|| |
...............................llaaaaleiegdrvllvhg.......tplsvqsseee............laellkeagadlvflGHtHk
YERMWpiynKNPFKSANPGHIK
.. .. ||| .
pkvek....rggtlvvnpGsvg
|
|||||||||
| PAPL | 126-324 | 3.1e-52 | 169.5 | In-house | 1-194 (194) | alignment | |||
Range on Protein: 126-324
Range on HMM: 1-194/194.0
AIFGDLSIIKGQQsIDQLIEATKQNQLDVIIHIGDLAYDLHDENGATGDDYMNAIEPFAAYVPYMVFAGNHEVDGDFNHIKNRFTMPRNGVYDNNLFWSF
|.|||| . .. . .| ..|.....|.|.|.|||||.....|. .||..|. |||.||.||||| .|||| . .|.. |.||.|| . ..| ..|
avfGDlGqtnass.lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesg
--TYGFVHIIAINSEYYAEEMSNEAKAQYQWLREDLAQN---TKKWTIVMFHRPWYCSSKKKKGCNDDqdilsregdKKKFPGLEELLNQYKVDMVLYGH
.| | . . || .| . ||.|| ||||.. . | |||.|||.|||.|.|. |... .|.. .||.|| .|.||.|| ||
snsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckek.........akmlaaledllykygVDlvlaGH
KHTY
.|.|
eHsY
|
|||||||||
| subfamily_ACP5_pd | Subfamily ACP5 | 127-325 | 4.9e-68 | 220.8 | In-house | 1-189 (189) | alignment | ||
Range on Protein: 127-325
Range on HMM: 1-189/189.0
IFGDLSIIKgQQSIDQLIEATKQNQLDVIIHIGDLAYDLHDENGATGDDYMNAIEPFAAYVPYMVFAGNHEVDGDFNHIKNRFTMPrngvyDNNLFWSFT
.||||.. . ..|...| . ...|.||.|||.|||||.|...|.|..|..||.|||.|..|||||..||||.| .|...|.||.|| ..| ..||
vfgDlgvse.aaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp.....sknewYsfd
YGFVHIIAINSEYYAEEMsneaKAQYQWLREDLA----QNTKKWTIVMFHRPWYCSSKKKKGCnDDQDILSREGdkkKFPGLEELLNQYKVDMVLYGHKH
|| ||.|....|.. . . ||.||..||. .....|.||| |||.|||.|... | . .. |.|.| ....||.||..||||..|.||.|
ygpvhfislstevdfslg....seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddc.tkeetlvrkg...lresledllykykvdlalsgHeH
TYE
.||
sYe
|
|||||||||
| Metallophos | Calcineurin-like phosphoesterase | 127-324 | 2.7e-19 | 63.3 | Pfam-A | 5-200 (200) | alignment | ||
Range on Protein: 127-324
Range on HMM: 5-200/200.0
IFGDLSIIKGQQ--SIDQLIEATKQNQLDVIIHIGDLAYDLHDENGATGDDYmNAIEPFAAYVPYMVFAGNHEVDGDFNHIKNRFTMPRNGVYDNNLFWS
..||| . . .|... .... |.... ||| . . .. .. . . .......|... ||||.|. . . .... .. .| ...
vigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeee
F-------TYGFVHIIAINSEYYAEEMSNEAKAQYQWLREDLAqNTKKWTIVMFHRPWYCSSKKKKGCnddqdilsrEGDKKKFPGLEELLNQYKVDMVL
. . . . .. ....|. .| ... . ..|.. |. . ..|...|.|...| . .. . ||.||..|.||.||
yenlkitllttsgelyglsglypllgdsaqeeqleeflalplr.alvdgkilltHgplsssggsgddi.........gselfgpdalekllekygvdlvl
YGHKHTY
.|| | .
rGHtHkp
|
|||||||||
| ACP5 | 134-322 | 1.2e-13 | 43.2 | In-house | 13-197 (198) | alignment | |||
Range on Protein: 134-322
Range on HMM: 13-197/198.0
IKGQQSIDQLIEATKQNQLDVIIHIGDLAYDLHDENGA---TGDDYMNAIEPFAAYVPYMVFAGNHEVDGDFNH-IKNRFTMPRNGVYDNNLFWSFTYGF
. .. .|. ........|... .|| || .. ... . . . ||..| .|||.. |. . |. . .. .. .. ..|.. .
ynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslryslskkevv
VHIIAI-----NSEYYAEEMSNEAKAQYQWLREDLAQNTKKWTIVMFHRPWYCSSKKKkgcndDQDILS-RegdkkkfpgLEELLNQYKVDMVLYGHKH
.... ... . .| ...|. | .||.. ||..|..|.||. | | | .... |.. | | |. ||..||||. | || |
telftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehg.....dtkelver.........llpllkkykvdaYlnGHdH
|
|||||||||
| subfamily_PAPL_pd | Subfamily PAPL | 141-323 | 2.5e-09 | 28.7 | In-house | 24-211 (212) | alignment | ||
Range on Protein: 141-323
Range on HMM: 24-211/212.0
DQLIEATKQNQLDVIIHIGDLAYD--LHDENGAT-GDDYMNAIEPFAAYVPYMVFAGNHEVDGD------FNHIKNRFTMPRNgVYDNNLFWSFTYGFVH
.| . ... . ......|| |. ..|.. | . . . . . ||..|.||||...|. . .. .|...| | ... .. . |.
kelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskrWkfpsl.yytksfkipdsnatvq
IIAINSEYY----------AEEMSNEAKAQYQWLREDLAQNTKKWTIVMFHRPWYcsSKKKKGCNddqDILSREgdkkkfpgLEELLNQYKVDMVLYGHK
.. |. . . .. |..|..||.|.|....... || | | . | ..| .|| .. |. ||..|.|. | ||
lvlidtvllcgksddlklegpvdvslaeeqwawleeeLkaseadylivaGhypvw..svaehGpt...kiLvkr........LkPlLekynvtaylsGhD
HT
|.
hn
|
|||||||||
| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 349-413 | 5.7e-17 | 53.2 | Pfam-A | 2-62 (62) | alignment | ||
Range on Protein: 349-413
Range on HMM: 2-62/62.0
APVYILTGGAGChsHEDPSDHIMQDFSVKALGEYGYTYLTVYNSTHISTDYVDTSstTGKFLDPF
|||.|..|.||. .... .. ....|. .|||. |||.|.||.. ..| .. .|. || |
ApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsd..dgqvlDsf
|
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