Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| GRP | Glycine rich protein family | 11-76 | 8.5e-06 | 12.7 | Pfam-A | 11-77 (95) | alignment | ||
Range on Protein: 11-76
Range on HMM: 11-77/95.0
LLFVFLVLISVCLAENKQqNHSPKINSSASPSKANKNN-GSN-NNNNNNKIDLTSNGGGSSSEGGDIN
||.....||| |.... ... | .... .... |.. . .. . .||| . || .
lllaavlLissevaaael.skeeksekeeevkdekyggggkhggGgygggggggngGGGykgggGgyg
|
|||||||||
| PhoD | PhoD-like phosphatase | 130-255 | 1e-09 | 28.9 | Pfam-A | 49-148 (453) | alignment | ||
Range on Protein: 130-255
Range on HMM: 49-148/453.0
TVNGKStTFSNWKGYSNSVVLTGLSPKTTYYYQCGGsssnilsqTNYFTTSNFPTTTTAntSGKNVKStttdnfqvtpFTAAVYADMGYGGGYNNTVKVI
.|. . .. . |. | .|||.|...|.|. .. ..| |.|. ...|.| .. ||.... | || |. . .
vrsgtv.latserdytvkvevtgLepgqeyfYrfra........eegesespvGrtrTl..peaaves..........lrlavvSCsnyeqGyfnayrel
EENlSKYSLILHIGDIAYADYnkveQ
|. ... ..||.||. |.. .
aek.edlDfvlhlGDyiYeyg....e
|
|||||||||
| Metallophos | Calcineurin-like phosphoesterase | 210-402 | 3.8e-18 | 59.5 | Pfam-A | 3-200 (200) | alignment | ||
Range on Protein: 210-402
Range on HMM: 3-200/200.0
AAVYADMGYGGGYN---NTVKVIEENLSKYSLILHIGDIAYADYNKVEQGNQTIwtnflQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPGSSNQP
.| .|...| .. .| |.|. ||. ... . |. . . ..... ..|.. ..|||.... | . ..... . .
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.....ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrgl
WYSYD-----------YNGVHFLSYSTESDLAPFTQQYQWIKNDLETYRKKNpsGWVIAYAHRPYYCSTQM-DWCrkqTLRALIESTIGELFQNYNVDIY
.. .. .|. . . . . .| . .|..|... ... |... ...|. .|.| ..|.. |. . .|...|.||..
angeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralv..dgkilltHgplsssggsgddi...gselfgpdalekllekygvdlv
LAGHTHAY
| |||| .
lrGHtHkp
|
|||||||||
| PAPL | 211-402 | 1e-47 | 154.8 | In-house | 1-194 (194) | alignment | |||
Range on Protein: 211-402
Range on HMM: 1-194/194.0
AVYADMGYGGGYNNTVKVIEENLSKYSLILHIGDIAYADYNKVEQgnqtIWTNFLQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPGSSNQPWYSY
||..|.|. ... |.. .||..|||.||.||||... |. .|.. .||....||||.|||||. | |..|...|.||||......|.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnew....dgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnss
---------DYNGVHFLSYSTESDLAPFTQQYQWIKNDLETYRKKNpSGWVIAYAHRPYYCSTQMD-WCRKqtlRALIESTIGELFQNYNVDIYLAGHTH
....|||. .|.|.| . .||.| ..||. ... |.|...||| |||.. . .|.. | . . . .|...|.||..|||| |
esgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsk.tPWiivmgHrpmYcsnkdkddcke...kakmlaaledllykygVDlvlaGHeH
AY
.|
sY
|
|||||||||
| subfamily_ACP5_pd | Subfamily ACP5 | 212-403 | 5.4e-63 | 204.3 | In-house | 1-189 (189) | alignment | ||
Range on Protein: 212-403
Range on HMM: 1-189/189.0
VYADMGYGGGYNNTVKVIEENLSKYSLILHIGDIAYADYNkveqGNQTIWTNFLQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPgsSNQPWYSYD
|..|.|. . . . .. ||. ....||.|.||.|||. . |...| .|....||..||||||...|||.....|..|...|.|| |.. |||.|
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalka....kneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfd
YNGVHFLSYSTESDLAPFTQQYQWIKNDLETYRKKNPSGWVIAYAHRPYYCSTQMDW-C--RKQTLRALIESTIGELFQNYNVDIYLAGHTHAYE
|..||| |.||| | .. ..||.|...||....... . |.|...|||.|||.. .. | .....|. ... .|...|.||..|.||.|.||
ygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHsYe
|
|||||||||
| ACP5 | 220-400 | 2.5e-11 | 35.6 | In-house | 11-197 (198) | alignment | |||
Range on Protein: 220-400
Range on HMM: 11-197/198.0
GGYNNT-----VKVIEENLsKYSLILHIGDIAYADynKVEQGNQT-IWTNFLQALEPITSKVPYMTAPGNHDVFYSFNSYQNTFNMPGSSNQPWYSYDYN
| || . .. . |.| ... .| .|| | | |.. ... . ..| . . . .||... ||||. . .. .. . .|. |.. | ..
geynqsavakqmgkvaekl.didfvlslGDnfydd..GvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslrysls
GVH-FLSYSTESDLAPFT--------QQYQWIKNDLETYRKKNPSGWVIAYAHRPYYCSTQMDwcrkqTLRALIEStIGELFQNYNVDIYLAGHTH
. . .. ||.. .. .. ..||. .|. |.| | | | . . |.|. . |...|.||.||.|| |
kkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehg.....dtkelver.llpllkkykvdaYlnGHdH
|
|||||||||
| Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 224-439 | 7.6e-08 | 24.5 | Pfam-A | 15-146 (156) | alignment | ||
Range on Protein: 224-439
Range on HMM: 15-146/156.0
NTVKVIEENlSKYSLILHIGDIAYAdynkveqgnqtiwtnfLQALEPItSKVPYMTAPGNHDVFYSFNSYQNTFnmpgssnqpwysydyngvhflsyste
.. .|.|. .. |||| ||. . .| . ...| . .|||| .... ..
aleavledi.kevdlilhaGDlvep................eevvell.edipvlavrGnhDeaelpkelavel..........................
sdlapftqqyqwikndLETYRKKNPSGWVIAYAHR---PyycstqmdwcRKqtlraLIESTIGELFQNYNVDIYLAGHTHAYERtvpvyqqspigtyEYP
|... . . |. . |. . . |. . ||......|... |||| .. |
................llaaaaleiegdrvllvhgtpls..........vq.....sseeelaellkeagadlvflGHtHkpkv.............ekr
GGTVHFTIGTPGNQ-EGLDH
|||.... |..|.. || ..
ggtlvvnpGsvgepregdea
|
|||||||||
| subfamily_PAPL_pd | Subfamily PAPL | 238-401 | 1.8e-06 | 19.3 | In-house | 37-211 (212) | alignment | ||
Range on Protein: 238-401
Range on HMM: 37-211/212.0
LILHIGDIAYADYNKvEQGNQTIWTNFLQALEPITSKVPYMTAPGNHD--------VFYSFNSyqNTFNMPGSSNQPWYSYDYNG--V-------HFLSY
..|..||. | . | . .. . ..| . . . .||... .|||| . || | . ...| . .... . | .|..
fvlalGDnfYekGvk.dvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYskls..krWkfpslyytksfkipdsnatvqlvlidtvllcg
S-------TESDLAPFTQQYQWIKNDLETyrkkNPSGWVIAYAHRPYYCSTQmdwcrKQTLRALIeSTIGELFQNYNVDIYLAGHTHA
. |. ..|..|....|.. . ..| | | . .. . . . | . . | ..|||. ||.|| |
ksddlklegpvdvslaeeqwawleeeLka....seadylivaGhypvwsvae.....hGptkiLv.krLkPlLekynvtaylsGhDhn
|
|||||||||
| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 422-482 | 2.5e-16 | 51.1 | Pfam-A | 2-60 (62) | alignment | ||
Range on Protein: 422-482
Range on HMM: 2-60/62.0
GTVHFTIGTPGNqeGLDHnWILPAPSWSASRFGELGYGQLNVVNNTHILWQFLTDQ-QVIFD
..|| ..|. || ||.. . | |.||| | . ||. |.|||.||. |.| .. . ..|
ApvhIvvGaAGn..glsk.fskpqpewsafresdyGysrltvvNrthLhwefvrsddgqvlD
|
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