Gene ppp4c in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP079_AA protein Get Run
DdisP079_AA_2-291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP4C_pd Subfamily PPP4C 3-290 5e-180 590.0 In-house 1-288 (288) alignment 
Range on Protein: 3-290
Range on HMM: 1-288/288.0
SDLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRY
||||||||.|.|||.|||.||.|||.||||||.||.||||||||||.|||||||||||.||||||||.|.|||||.||||||||||||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIP
|||||||||||||||||||||||.||.|||||..||.||||.||||||.|..|||||||||||||||.|||.||.||||||||||||.|||.||||||. 
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQE
||. ||||||.|||.|||..||..|..|.|||||||||||.|..|||...|||||||||||||||||||.|||.|.|.|.|||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 3-290 1.4e-155 509.7 In-house 2-289 (290) alignment 
Range on Protein: 3-290
Range on HMM: 2-289/290.0
SDLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRY
.|||..||.||.|. ..||||..|| ||.||| .| ||| | .|||.|||.||||.|| ||||.||..|.|||||.||.||||.|||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIP
..|||..||||||||||||||||.||.||||. .|||| |..||||.|.||||..|||.||||||||.|||.|||.|| ||||||||.|||.||||.|  
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQE
||. ||||||. ||.|. .|||. |.|..| |||||||||....... .||..||||||||||| ||||.||..||..|  |..||..
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
0045823 Metallo-dependent phosphatases 3-291 5.2e-120 394.2 In-house 28-328 (473) alignment 
Range on Protein: 3-291
Range on HMM: 28-328/473.0
SDLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRY
.|||. ||.||......|.... |...|.||| .| |..... .....||||||..||..|..  |  | ....|.||.|||| .|.|...||||||..|
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PDRITLIRGNHESRQITQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIP
|....|.|||||.|.....|||..|. .|| .. ..... | ...| |.|...|||..|||||||....|||||.|.| .|.|..|...||.||||... 
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

G--------WNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNET------LVTVWSAPNYCYRCGNVAAILQLDENLkKNFAIFEAAP
|        .  ||||||.|||.|.|..| ..|.| .|.|.|. |.||....|.        ..||.||||||.|.|| ||.|..||.|  .| .|...|
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

QES
.. 
hpl
0049330 Metallo-dependent phosphatases 3-290 5e-113 370.2 In-house 15-302 (309) alignment 
Range on Protein: 3-290
Range on HMM: 15-302/309.0
SDLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRY
|.||..||.|... ...|.|.. |. ||.|||..|.|..... .....||||||..||..|..  |  | ....|.||.|||| .|.|..|||||||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRITLIRGNHESRQITQVYGFYEECVRKYGsVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPE-DI
||...|.|||||.|.....|||..|..|||| . .|..... ...| | |...|||.||||||||....|||||...| .|.|..|..|||.||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

PGWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQE
.|. ..|||.|..||...|..| . |.|..|.|.|..|..|....|.. |.||.||||||.|.||..|.|..||.|. .| .||..|..
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 3-288 3.7e-109 357.5 In-house 7-292 (293) alignment 
Range on Protein: 3-288
Range on HMM: 7-292/293.0
SDLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRY
..||..||.|... ...|.|.. |. .|.|||..|.|..... .....|||||...||..|..  | .| ....|.||.|||| .|.|...||||||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIP
||...|.|||||.......|||..|..||||.  .|..... ...| |.||..|||..|||||||....||||| |.| ...|.||...||.|||| .. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAP
||  |.||.|..||...|..| . |.|..|.|.||.|..|....|.. ||||.|||||..|.||..|.| |||.|. .| .|.. .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP6C_pd Subfamily PPP6C 4-292 7.4e-153 500.7 In-house 1-289 (290) alignment 
Range on Protein: 4-292
Range on HMM: 1-289/290.0
DLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYP
.||. ||. |.|. . |.....||..  ..||||.||| | ||||.|||||||||||.|||. ||. |.|.|.|.|||||||.||.||| .||.||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIPG
|||||.||||||||||||||||.||..|||....|||||..|| |...|..|....|||||||| ..|||||| |.| ||.||.|..|||.||||||.  
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQESR
|. ||||||.|||. |...|.| |||..||||||||.||.||||.| ||||||||||||||||||.||.|... .... .|.| |.| |
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP7C_pd Subfamily PPP7C 4-182 1.8e-37 122.0 In-house 19-203 (383) alignment 
Range on Protein: 4-182
Range on HMM: 19-203/383.0
DLDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDS----PVTICGDIHGQFYDLKE-LFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLAL
.... ||..|. ....   |  .  .|...| .  |..|| .     ||.|||.||.. ||   |.| |   .. .|.| |||||||  |||  |.||||
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KVRYPDRITLIRGNHESRQITQVYGFYEECVRKY--GSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSiNTLDQIRAIDRKQ
 . ||  . | |||||   .   |||  |   ||   .  . .   ..| .| |..|.| ||. ||||.| .   |. .  |.|..
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkiersk
subfamily_PPG1_pd Subfamily PPG1 5-290 2.8e-133 436.8 In-house 1-299 (300) alignment 
Range on Protein: 5-290
Range on HMM: 1-299/300.0
LDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPD
||. .|.|...|.. |. |..|. | .|.|..| ||... ||||. ||.||||||. |.||.||..|.|||||.||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYEECVRKY-GSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPE----
||||.|||||||||||||||| ||.||| |  .|||| |||||||.|.|..| .|.|||||||||. ..|||. .|| .|||.|| ..||.|||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

---DIPGWNG-----SPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQE
   | |  .|     |.||||. .|.|||.|| . |... | |||||..||.. .|.. | |||||||||||||| |.||.| |.... | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-287 1.4e-96 316.0 In-house 11-294 (298) alignment 
Range on Protein: 5-287
Range on HMM: 11-294/298.0
LDRQIEQLKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPD
|   ... | ...|||..|  |...|..|. .   .  ||.|...|||||||. ||  ||. .|  |..||||.||.|||| ...|. .|||| ||.||.
lsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypn

RITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPED-IPG
.. |.|||||  .| .|||||||| |.| |.....   ..|. | | ||. |.|.|.|||||. ...|||.|.. | .. ..|    ||.|.|||. . |
nffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkg

WNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAA
|. . ||... ||||||... .. ......||||.| .|.... .  |||..|||.|| .  | ||....||.|.  | ..  .
waensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPP3C_pd Subfamily PPP3C 12-277 5.6e-86 282.1 In-house 35-313 (452) alignment 
Range on Protein: 12-277
Range on HMM: 35-313/452.0
LKRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRG
...   ..|...  . ..| ..| .| .. .|..|.|..|||||||||| .||.||||  .|.|||.||.|||| .|.|. | |.|||. ||... |.||
flkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrG

NHESRQITQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIPGW-------
|||.| .|. . | |||  || | .|.. |.| || | |.||.... .|||||||| |..||.|. .|| .|.|. ||.|||.|||| .  |        
nhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekf

-NGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFN------ETLVTVWSAPNYCYRCGNVAAILQLDENL
 . |.||  ....   | .| ..|.|  | |||.   .|..   .       .|.|..|||||.    | ||.|....| 
vpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 12-287 1.7e-83 273.0 In-house 2-275 (280) alignment 
Range on Protein: 12-287
Range on HMM: 2-275/280.0
LKRCeiIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRG
| .|  ||| .. ..  | ..||. .  .  ||.||..|||.|||. ||  ||.  .  |..||||.||.|||| . .|  ||||| |||||... ..||
llac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrg

NHESRQITQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPE-DIPGWNGSPRG
|||  .| . |||..|. |.| |  ...   |..| | | ||| |.|.|.|||||. . .||... . |  . ..|    ||.|.||| .. ||  ..||
nhevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrg

AGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAA
.  .||..||... .  ....|.| ||.| .|.... .  ||||.|||.|.    | ||.|..||.|.  | ..  |
vsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 13-285 1.9e-78 256.8 In-house 18-293 (297) alignment 
Range on Protein: 13-285
Range on HMM: 18-293/297.0
KRCEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGN
  ...| |  |  |   | ...  . ..  |..|. .|||||||| ||  ||. ||  | .||||.||.|||| .|.|| .|||| ||..|  . |.|||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSP---SINTLDQIRAIDRKQEVpHEGPMCDLMWSDPE-DIPGWNGSP
||   . .|||||||| ..| || ..    ..|..| |. |.  ||.|.||||||      ||| .| |.| .|  .|. ..||.|.||   . |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFE
||||  || | | |   . .|...|||||.| .|....    |||..||| || .  |.||..  ||.|.  | |. 
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 15-283 9.9e-71 231.4 In-house 3-271 (280) alignment 
Range on Protein: 15-283
Range on HMM: 3-271/280.0
CEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
|...   |. |.      |..|| |.   ..|. . |||| |. |.. || . |  |. . .|.||.||||   .| ..||..||.|| ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYEECVRKYGSVTVWKYcTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPED-IPGWNGSPRGAGF
.  . ..|||| ||  |||    | .   .|. . .|.|.  ...|.|||||| .  || || | |  |    | . ||.|||| .   ||  | ||  .
tpsvnkiygfyvecqykygvglwwdf.qscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAI
.||. ||..  .  ....| ||||.| .|.. |    |.||.| |||| .  | ||.. |. ||. .|  
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 15-284 2.8e-67 219.8 In-house 13-286 (290) alignment 
Range on Protein: 15-284
Range on HMM: 13-286/290.0
CEIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
 . ......  .  |..|||     . .| .|..| ||||||. .| . |.  |  |. ..||.||.||||  |.|  |||. .|.||. .. |.|||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

SRQITQVYGFYEECVRKYGSvTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQ--EVPHEGPMCDLMWSDPED----IPGWNgSP
 |.. ..|||.|| .|| ||  .||   ..|. ||| | |. ||.|.|||.|. |.. . ..|. . .     .|| . ||.|.||.         |   
vrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialn.kq

RGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIF
|.   .||....... .   |..| |||..  |||...|.. ||||.||| |. .  |. ||... | |. .....
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_PPP1C_pd Subfamily PPP1C 16-287 6.8e-107 349.8 In-house 8-279 (282) alignment 
Range on Protein: 16-287
Range on HMM: 8-279/282.0
EIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
  .||.|..||..|||||||..  . ... ||.|.||||||..||  ||. .|  |..||||.||.||||  |.|| .||||.|..||... |.||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYEECVRKYGSVtVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPE-DIPGWNGSPRGAGFL
 .|...||||.|| |.|..  .||  |..|..| |.|||| ||.||||||||... |.||| | |  |||..| .|||.||||. .. ||. . ||  | 
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAA
||.|||.|| ..|.|..|.||||.| .|.... .. ||||.|||||| . .| .|.|..||.|. .| |. .|
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 16-285 9.7e-87 284.0 In-house 6-281 (284) alignment 
Range on Protein: 16-285
Range on HMM: 6-281/284.0
EIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDC------PQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLI
...|| |.  || .|||.. .|   . ...||.|.||||||| ||. |... |         ...|||.||.|||| .|.|  .||.|.|...||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPE-DIPGWNGSP
||||||| . . ||||.||...| |.....     |  . |.|.|. ||.|.|||.|  .  |.|. ...|  ..|  | ..|| |.||| .. |.. ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFE
|||| .||.. |..|..  .|... ||||.||.|.... .  |||..||| || .  |.||.|..||.|   |....
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 16-290 1.9e-84 276.4 In-house 22-297 (299) alignment 
Range on Protein: 16-290
Range on HMM: 22-297/299.0
EIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
. .|| |.. ||. |.......  .  |..|. .|||||||. ||  .|.. |  |..|.||.||.||||   .|.  |||. |..||.|. ..||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPED-IPGWNGSPRGAGFL
  | .|||||||| ..| |  .|    . |... |. |. ..|.|.|||||| ..||||.| . | |. |      ||.|.||.. . .|    ||  ..
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAPQE
||.|||..  .  ......||||.| .|.... .  |||..||| || .  | |||...||||   | ... .|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 16-284 7e-81 264.5 In-house 5-274 (281) alignment 
Range on Protein: 16-284
Range on HMM: 5-274/281.0
EI-IKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
.. . . |. ..  ... |. || ..  .|.|... ||.|.|| |||.||.. |  |.. ..|.||.||||  |.|...||..||.||.||| |.|||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

SRQITQVYGFYEECVRKYGsVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPED-IPGWNGSPRGAGF
  .. ..||||.||| ||| . .|    . |. | .|||.. .. |.|||||| . .||..| . .  . .. | . ||.|.||..   .|  | ||..|
iasvnkiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

LFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIF
.||..||..     ..|.| ||||.|..|.. .    |.||.|.||||    | ||.|..||.|. ..  .
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 16-284 8.4e-74 241.0 In-house 8-279 (287) alignment 
Range on Protein: 16-284
Range on HMM: 8-279/287.0
EIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
. ......  .  |..|||     . .|..|.||.||||||. ||  .|.  |  |...|||.||.||||  |.|  |||..||..|| .. |.||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYEECVRKYGsVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQE--VPHEGPMCDLMWSDPE-DIPGWN-GSPRGA
..| ..|||.||  ||..   ..|   ..|..|.| | |. .|.|.|||.|| ...||...|. . .     .|| . ||.|.||| |  . .    |. 
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

GFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIF
  .||. .|... .  ....| |||... ||....|.. ||||.||| |. .  |..|...... |. .|  .
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 16-68 1.7e-13 43.5 In-house 7-59 (317) alignment 
Range on Protein: 16-68
Range on HMM: 7-59/317.0
EIIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGG
...||.|.  || .|||.. .|    ....||||.||||||| ||. |... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPZ_pd Subfamily PPZ 17-285 5.2e-81 265.4 In-house 24-292 (300) alignment 
Range on Protein: 17-285
Range on HMM: 24-292/300.0
IIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 .|.||.  .| ||||..| . ..  .  .| | ||.|||. ||  ||   |  |..||||.||.||||  |.|| ||||. |..||. . |.|||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIP-GWNGSPRGAGFLF
..|.|||||.|| |.   . .||   . |. | |.|.| |||||||||||| .|..|.|| . |  .||  | . ||.|||| | .  |.   ||  . .
nvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFE
 .  ..||     ....|||| .| .|.... . .||||.||||||    |  |.. . | |  .| ...
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelld
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 17-67 3.7e-08 25.8 In-house 10-60 (339) alignment 
Range on Protein: 17-67
Range on HMM: 10-60/339.0
IIKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVG
..  .|.  || .|||..  |  . ....|. . ||||||| ||  .. . 
lfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmn
PPP_3 18-285 1.6e-122 400.7 In-house 2-270 (271) alignment 
Range on Protein: 18-285
Range on HMM: 2-270/271.0
IKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
..|.|.. |..|..||| .| |......|||.|||||||..|| ||||.||..|.|.|||.||.|||| .|.|..|||||||..||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDL-MWSDPEDIPGWNGSPRGAGFLFG
|..||||..|...|.|. .|.|...|.|..|.|.||.|.|...|||||||||..||||. ..||.|||.||...|| ..||||.  |.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

EDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFE
.||...|...|.|..|.|||.|..||....... .|||.||||||.|..|..|||.|.|.|...|...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 18-284 7.7e-72 235.1 In-house 3-271 (284) alignment 
Range on Protein: 18-284
Range on HMM: 3-271/284.0
IKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
|   .| .|  .| .|. ..  .  |.||. ||||||||| ||  ||   |   ..||||.||.|||| . .|| |||.| || .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPM-CDLMWSDPEDI-PGWNGSPRGAGFLF
| ..||||||| |.|   .|..    .|  . |.|||  .|.|.|||.|  .. . |.||| |  . |    .  |..|||| ..  |||   ||  ..|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIF
| | ..|.    ..... ||||.| .|.... |  |||..||| || .  | ||.. ...||   | ..
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 18-284 3.3e-56 183.7 In-house 6-297 (302) alignment 
Range on Protein: 18-284
Range on HMM: 6-297/302.0
IKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKV-----------GGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ..||. .|...  | | .| .. .. .|||| ||||||| ||  ...                 .  ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYEECVRKYGSVT---VWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRK-QEVPHEGPMCDLMWSDPEDIP
 |.|||||.. |   ||| || . ..|      .|.   |.| .. |.|||  ||.|||||.|| ...|..|. |.|  .|| ..    ||...|| |. 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWN----------GSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIF
.               ||  ..| |  |... .  ||..| |||| . ||||.. .. |.|..|||.|     |  |.|..| | | . ...
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 18-283 5.6e-56 182.9 In-house 7-297 (302) alignment 
Range on Protein: 18-283
Range on HMM: 7-297/302.0
IKESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKV-----------GGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ..||. .|...  | | .| .. .. .|||| ||||||| ||  ...                 .  ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYEECVRKYGSVT---VWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRK-QEVPHEGPMCDLMWSDPEDIP
 |.|||||.. |   ||| || . ..|      .|.   |.| .. |.|||  ||.|||||.|| ...|..|. |.|  .|| ..    ||...|| |. 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWN----------GSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAI
.               ||  ..| |  |... .  ||..| |||| . ||||.. .. |.|..|||.|     |  |.|..| | | . ..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisv
PPP_1 19-272 1.6e-113 371.3 In-house 2-263 (264) alignment 
Range on Protein: 19-272
Range on HMM: 2-263/264.0
KESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
.|.|...|..|..|.| .| |...|....|.||||||||.|| .||||||..|.|||||.||.|||| .|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYEECVRKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDL--------MWSDPEDIPGWNGSPRG
|.||||..|...|..| ...|..|..||.|.|.||.|.||..|||||||....||||| ..||.|||.||..|||        ...|.|.  ... |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQ
||.|||.||..||.. |||..|.|||....||.........||..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 19-286 9.2e-108 352.4 In-house 2-269 (271) alignment 
Range on Protein: 19-286
Range on HMM: 2-269/271.0
KESEVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
...||..|.....||| .| |. .|..|||..||||||..|| .|.. .| .|...|.|.||.|||| .|.|. |||.|||..||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDP-EDIPGWNGSPRGAGFLFGE
...|||.||. ||| .  ... ..|.|..|.|.|||| ||.|.||||||....||.|| ..| .| |.||...||.|||| .. .|.. | ||....|||
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEA
|.|..| . |||. |.|||..|.||....... |||..||||||....|.||.|....||| ..  ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 22-284 3.4e-63 206.7 In-house 24-289 (307) alignment 
Range on Protein: 22-284
Range on HMM: 24-289/307.0
EVRALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQV
|.  .  .|. |.  |  .  .| |. . ||.|||| || ..| . |  |.| |.| ||.||||. |.|. |||.. |. ||. | |.|||||  .. . 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYEECVRKYGS--VTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDLMWSDPE-DIPGWNGSPRGAGFLFGED
||||||||         .|      |. | .|||.  ||.|.||||||..  ||..|   .    |  | . |..|.||.  .  |. | ||.|| || .
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

VVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIF
|..   .   .|.| ||||....|.  .    |.|..||| ||    |  ..|..|| |  .   |
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvaf
subfamily_PPPLV_pd Subfamily PPPLV 24-274 9e-56 182.3 In-house 3-276 (290) alignment 
Range on Protein: 24-274
Range on HMM: 3-276/290.0
RALCSKAREILLEEGNVQRVDSPVTICGDIHGQFYDL----KELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQIT
 .||..| .||..| ..  ..||. . ||.||.. ||    | |...| |   ...||.||.|||| .|||    |||||| || .. |.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYEECVRKYGSV--TVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQ---EVPHE-GPM-CDLMWSDPED---IP-------
. . .. |.  |.|     ||.  ...||.| |.| .| |.||||.|.  .| |  .| ||.      . . .  |.  |..||||..    .       
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GW-NGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCgNVAAILQLD
  |. . . || | .|.|| ...| . |||.|. |||.   .|...  .  |.||.|. .||    | ||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvd
subfamily_PPP5C_pd Subfamily PPP5C 25-288 6.2e-84 274.7 In-house 41-310 (322) alignment 
Range on Protein: 25-288
Range on HMM: 41-310/322.0
ALCSKAREILLEEGNVQRVD----SPVTICGDIHGQFYDLKELFKVGGDCP-QTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQIT
.. ..|.|.| ..  .  ..    . .|.||||||||||| ..|.. |    .  ||| ||||||| .|||. |.||..|. ||... | |||||| .. 
killeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmn

QVYGFYEECVRKYGSvTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSP-SINTLDQIRAIDRKQEVPHEGPMCDLMWSDPEDIPGWNGSPRGAGFLFGED
..||| .|.  || . .| .  ||.|..| |. ... |.. |||||      |||..| ||| .. |.|| ...|.||||.. .| . | || |. || |
klyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpd

VVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQL-DENLKKNFAIFEAAP
| .|| ..|||| | |.|.. .||.. . .  |.||.|||||| . || .|...| ...|| .|  ||| .
vtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 43-283 2.1e-54 177.9 In-house 5-252 (263) alignment 
Range on Protein: 43-283
Range on HMM: 5-252/263.0
VDSPVTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKYGSV----TVW
...|. |||| |||. ||  .|.  | . .|.|||.||.|||| .|.|  .||..||.  | .. |.||||| . | . |||. |  ...       .|.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPM-CDLMWSDPE-DIPGWNGS-PRGAGFLFGEDVVQKFNHDNNLEFICRA
..  ..| |. | |.|  .|.|.|||.|| ...||.||||    |  .  |. |||.|.||| |  |..    |    .||.  |. . .  ....| ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAI
||.|  |. .. .  |.||.||  |     | ||.. ... |. .|  
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvq
Metallophos Calcineurin-like phosphoesterase 46-238 1.1e-46 152.7 Pfam-A 2-198 (200) alignment 
Range on Protein: 46-238
Range on HMM: 2-198/200.0
PVTICGDIHGQFYDL----KELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLL--LALKVRYPDRITLIRGNHESRQITQVYGFYEECV----------
.....||.||...||     .|.|...... ...||.||.|||| .| ||. ||  |.||...|... |.||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLDQIraidrkqevphegpmcdlmwsdpedipgwng
                       ....   .. .. |.|..|.| |||||||...||.||.| .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFLFGEDVVQKFNHDNNLEFICRAHQL
    ...|||.|.. |.  ....  ..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 47-238 3.1e-83 271.3 In-house 1-197 (198) alignment 
Range on Protein: 47-238
Range on HMM: 1-197/198.0
VTICGDIHGQFYDLKELFKVGGDCPQTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEIFD
||.|||.|||..|| .|||.|...|...|||.||.|||| .|.|..|||||||..||....|.||||||.....||||..|...|.|. .|.|...|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVPHEGPMCDL-----MWSDPEDIPGWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQL
.|.|.||.|.|...||||||..|..||||. ..||.|.|.||...||     .....|.  ... | ||||.|||.||.... ..|.|..|.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 47-238 3.1e-78 255.4 In-house 1-196 (197) alignment 
Range on Protein: 47-238
Range on HMM: 1-196/197.0
VTICGDIHGQFYDL-KELFKVGGDCP-QTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKyGSVTVWKYCTEI
||..||||||..||  .|.|.||. . ...|.|.||.|||| .|.|..|||||||..||....|.||||||......|||..|...|  . ...|.....
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVP-HEGPMCDL-MWSDPE-DIPGWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQL
||.|.|.||.|.|...||||||.....||.|..|.||.|.| .|. ..|| .||||. .  |.. | ||||.|||.||..|| ..|||..|.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 47-238 1.1e-76 250.3 In-house 1-198 (199) alignment 
Range on Protein: 47-238
Range on HMM: 1-198/199.0
VTICGDIHGQFYDL-KELFKVGGDCP-QTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKYGSVTVWKYCTEI
||.|||.|||..||  .||| ||| . ...|.|.||.|||| .|.|..|||||||..||....|.|||||..|....|||..|...||..  ..|.....
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLSALVDGKIFCVHGGLSPSINTLDQIRAIDRKQEVP-HEGPMCDL-MWSDPE-DIPG-WNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQL
||.|.|.||.|.|...|||||||.|........|.||.|.| ..| ..|| .||||. .  | .  | ||||.|||.||..|| ..|||..|.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 47-131 9.2e-06 18.3 In-house 12-87 (235) alignment 
Range on Protein: 47-131
Range on HMM: 12-87/235.0
VTICGDIHGQFYDLKELFK--VGGDCPQTNYLFMGDFVDRGFYSVETFLLLlalkvrYPDRITLIRGNHESRQITQVygfyeECVRK
. . ||.|| . .| ||..  .||  ..   ...||....|  |||.  ..        |    ..||||   . ..     . |.|
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 72-285 7.4e-74 241.8 In-house 100-313 (317) alignment 
Range on Protein: 72-285
Range on HMM: 100-313/317.0
QTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKYgSVTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINT
. .|||.||.|||| .|.|  .||.|||..|||...|.||||||| . . ||||.|. ..| |.....    .|  | |.|.|. ||.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDQIRAIDRKQEVPHEGPMCDLMWSDPE-DIPGWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAI
|.|. ...|  ..|  | ..|| |.||. .. |.. |.||||..||.. |..|..  .|... ||||.|..|.... .  |||..|||.|| .  |.||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

LQLDENLKKNFAIFE
|..|..||  .....
lsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 74-286 1.9e-55 181.3 In-house 121-333 (339) alignment 
Range on Protein: 74-286
Range on HMM: 121-333/339.0
NYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYEECVRKYGSvTVWKYCTEIFDYLSLSALVDGKIFCVHGGLSPSINTLD
 |||.||.|||| .|.|  .|| |||. ||||| |.||||||| .   |||| |   .| .  ...   ..|. . . |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRAIDRKQEVPHEGPMCDLMWSDPEDI-PGWNGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQ
|.  . |  |.|  | . || |.||.    |.. | ||| |.||   .. | .  .|... | ||.| .|....    |||..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDENLKKNFAIFEA
.|..||    .|  
idkklkisinvfrp
subfamily_PPP7C_pd Subfamily PPP7C 190-288 1.6e-19 62.9 In-house 237-336 (383) alignment 
Range on Protein: 190-288
Range on HMM: 237-336/383.0
MCDLMWSDPEDIPGW-NGSPRGAGFLFGEDVVQKFNHDNNLEFICRAHQLVMEGFKYMFNETLVTVWSAPNYCYRCGNVAAILQLDENLKKNFAIFEAAP
. |..||||.   |    . ||.|  || || .|. .  ||... |.|.  .||.... .....|..|| ||     |  | ..| ..|. ..  . |. 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask