Synonym: CG12252, DmFcp1, Dmel\CG12252, Dmfcp1, fcp1, Dmel_CG12252, Fcp1
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| Biotin_lipoyl_2 | Biotin-lipoyl like | 67-88 | 3.4e-06 | 14.2 | Pfam-A | 11-32 (50) | alignment | ||
Range on Protein: 67-88
Range on HMM: 11-32/50.0
AVINKWRVREGQFVSAAQILFL
... .. |.|||.|.. ..|.
GrVeevlVkeGqeVkkGDvLle
|
|||||||||
| CPDc_SM00577 | 206-351 | 1.2e-35 | 114.7 | In-house | 1-145 (146) | alignment | |||
Range on Protein: 206-351
Range on HMM: 1-145/146.0
RKLVLLVDLDQTVIHTTNDTVPDNIKGIYHF----QlygphsPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGkFFSHRILSRDE
.|.||..|||.|..|..| . |.... . . .... .||.. |||.....|.||.| | . ..||. |..||||.. ...|.|.|..
kkkvLVlDLdetLvhsanmaepksfsevsptdslae......tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkr.llkyrvlyRqd
CFNATSKTDN-LKALFPNGDSMVCIIDDREDVWNMAS-NLIQVKPYHFFQHT
| . ..| . |.. .|.|.|||..|..... |....|||......
crlvkgkllkddlsllkvdlskvviiDnseestlvnpenalkikpyisalsd
|
|||||||||
| subfamily_FCP1_pd | Subfamily FCP1 | 207-349 | 3e-65 | 210.8 | In-house | 1-146 (146) | alignment | ||
Range on Protein: 207-349
Range on HMM: 1-146/146.0
KLVLLVDLDQTVIHTTND---TVPD-NIKGIYHFQLyGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDEC
||||.||||||.||||.| .|.. . |.| .|.| .. .|...|||...||||..|.||||||.|.|.|.||..||..||||.|.||.|||||||.
klvLvvDlDqtlihttkdptievkeekkkdikkftl.peekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrdel
FNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQ
..|.|||..||.|||..||||.||||||||||.|.|||.||||.||.
ldassktkklkklfptddsmvviiDDredvWnfaenlikvkpykffk
|
|||||||||
| NIF | NLI interacting factor-like phosphatase | 209-347 | 1.4e-26 | 85.2 | Pfam-A | 2-132 (159) | alignment | ||
Range on Protein: 209-347
Range on HMM: 2-132/159.0
VLLVDLDQTVIHTTNDTVPdnikgI-----YhfqlyGpHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFsHRILSRDEC-
.| .|||.| .|.. .. .. ... .||| .|||...|. ||. |.| . ..||. . . |||..|.| ...|.|..|
tLVLDLDetLvhskekkdl.....kedgkkv.....e.ektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklf.kkrlyresct
FNATSKTDNLKALfpNG-DSMVCIIDDREDVWNM-ASNLIQVKPyhF
.. .....|. | . | | |.||....... .|.|...| |
lrngkyvKdLsll..grdlsrvvivDdsprsfelqpdngipiep..f
|
|||||||||
| subfamily_DULLARD_pd | Subfamily DULLARD | 209-345 | 8.5e-14 | 43.5 | In-house | 3-145 (153) | alignment | ||
Range on Protein: 209-345
Range on HMM: 3-145/153.0
VLLVDLDQTVIHTTNDT-----VPDNIKGIYHFQLYGPH-SPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILsRDEC
.|..|||.|.||...|. | .... . ... . . .. || .||...|. |.| | | ....||. ... || . ...| |..|
tlvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryy.rqhC
FNATS-KTDNLKALFPNGDSmVCIIDDREDV-WNMASNLIQVKPY
. .. | .| .. .. .| |.|.|. . . | |..| .
vlesgkytkdlslvssdlss.viilDnspvayrknpdnaipiksw
|
|||||||||
| subfamily_SCP_pd | Subfamily SCP | 209-316 | 9.9e-11 | 33.6 | In-house | 2-106 (142) | alignment | ||
Range on Protein: 209-316
Range on HMM: 2-106/142.0
VLLVDLDQTVIHTTNDTVPdNIKGIYHFQLYGPHSPWYHTRlRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEgKFFSHRILsRDECFNAT-S
.|..|||.|..|.. |. | . .. | . | . || |||.|...|.|. . | .||. .|.||| . |....|.. |..|.. .
clvidldetlvhssfkpvk.nadfvvpveidgtvhqvyvlk.rphvdeflkrvgelfevvlftaslakyadpvadlldkk.kvlrarlf.rescvfhkgn
KTDNLKALF
.| |
yvkdlsrlg
|
|||||||||
| subfamily_CTDSPL2_pd | Subfamily CTDSPL2 | 210-307 | 2.4e-14 | 45.5 | In-house | 2-96 (142) | alignment | ||
Range on Protein: 210-307
Range on HMM: 2-96/142.0
LLVDLDQTVIHTTNDTVPDNIkgIYHFQLYGPHSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRiLSRDECFNATS
|..|||.|..|.. . ... . . |. . . |||| |||||.|.|.|. . | . ||. . .||||| |.. || | |..| ..
lvldldetlvhcslekleeat..ltfpvlfenktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklikhr.lfrehcvcvdg
|
|||||||||
| subfamily_TIM50_pd | Subfamily TIM50 | 246-346 | 6.3e-08 | 24.8 | In-house | 21-120 (126) | alignment | ||
Range on Protein: 246-346
Range on HMM: 21-120/126.0
YHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGkFFSHRILSRDECFNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPY
. .. ||| . |||....|.|. . | .|. . . |||.. . ..|.. . ... .|. | . . .. . |.. | .| ...|..
wrfkkrPgvdafleqlaelfeivvftseqgltaaplidkldPkq.limyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkksvklqpenalalkkw
H
.
e
|
|||||||||
| BRCT | BRCA1 C Terminus (BRCT) domain | 590-665 | 2.1e-09 | 27.0 | Pfam-A | 5-77 (78) | alignment | ||
Range on Protein: 590-665
Range on HMM: 5-77/78.0
VLRGKNLVFsglvPTQMKLEQSRAYFIAKSLGAEVKPNIDKEITHLVAVNA--GTYKVNAAKkEPAIKVVNANWLWTC
.. |.. .. | . ... . ...|.||..| ....|..||||. . .| |..||. .. |..|| ||. |
lFeglkfyi....gtfdnfnreeleelikelGGkvstevskktthlvvgepelrtlkylaai.alnipivneeWlldc
|
|||||||||
| PTCB-BRCT | twin BRCT domain | 598-661 | 2.7e-11 | 32.9 | Pfam-A | 5-63 (63) | alignment | ||
Range on Protein: 598-661
Range on HMM: 5-63/63.0
FSGLVPTQmkleQSRAYFIAKSLGAEVKPNIDKEITHLVAVNAGTYKVNAAKKEPaIKVVNANW
.||. ... .| ....|||... .. |..|||.. .|.. |. .|.| |.||...|
vsgysgdd....rkrlqkliralGasiskdltkkvTHLickraegeKyekAqkwg.ipvVspeW
|
|||||||||