Gene CG1637 in Drosophila melanogaster

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily PAPL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP083_AA protein Get Run
DmelP083_AA_154-358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PhoD PhoD-like phosphatase 103-238 2.7e-11 34.1 Pfam-A 56-180 (453) alignment 
Range on Protein: 103-238
Range on HMM: 56-180/453.0
HKQATQFIHRVTLRDLEPNATYSYHCGS--DFGWSAIFQFRTVPSASVDWsPSLAIYGDMGNEN--AQSLARLQQETQrgmYDAIIHVGDFAYDMNtkna
 ....... .|....|||. .| |.  .  .   | . ..||.|.|.|.   .||.....  |.   . ...| ....   .|...|.||. |  .    
atserdytvkvevtgLepgqeyfYrfraeegesespvGrtrTlpeaaves.lrlavvSCsnyeqGyfnayrelaeked...lDfvlhlGDyiYeyg....

rvgdefM---RQieTVAAYLPYMVVPgnHEEKFNFSNYRARFS
          ..  ....     | |  ..| .. ..||.|..
......egtykn..eereekgrvvep..ekeivtladYRkrya
PAPL 155-358 6.1e-76 246.9 In-house 1-194 (194) alignment 
Range on Protein: 155-358
Range on HMM: 1-194/194.0
AIYGDMGNENAQSLARLQQETQRGMYDAIIHVGDFAYDMNTKNARVGDEFMRQIETVAAYLPYMVVPGNHEEKFNFSNYRARFSMPGGTENMFYSFDLGP
|..||.|..||.||.|||.|||.|.||||.||||.||.....|...|||||||||..||..||||.||||||..|||||.|||||||..|....|...|.
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgs

VHFvGISTEVYYFLNYGLKPLVFQFEWLREDLAKANLPENRNKRPWIILYGHRPMYCSNENDNDCTHSETltrvgwpfvHMFGLEPLLYEFGVDVAIWAH
 ..  ..||...|.... .  | . ..  |.| ... ..||.|.||||..|||||||||....||.....         ....||.|||. |||. ...|
nsy.sfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekak.........mlaaledllykygVDlvlaGH

EHSY
||||
eHsY
Metallophos Calcineurin-like phosphoesterase 155-358 2.1e-23 76.6 Pfam-A 4-200 (200) alignment 
Range on Protein: 155-358
Range on HMM: 4-200/200.0
AIYGDMGNENAQS---LARLQQETQRGMYDAIIHVGDFAYDMNTKNARVGDEFmRQIETVAAYLPYMVVPGNHEEKFNFSNYRARFSMPGGTENMFYSFD
.. ||..  ....   | .|..  ...  |.... ||. .  .  .   ..   .. . .... |.....|||| ..  | | ..  ...  .  .. ..
lvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.ylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

LGPVHFVGISTEVYYFLNYGLKPLVFQFEWLREDLAKANLPENRNKRPWIILYGHRPMYCSNENDNDCthsetltrvGWPFVHMFGLEPLLYEFGVDVAI
 .  ..... |  . . .   .    ...  .| | . .....|.. ...|| .|.|...| .. .|          | .      ||.||.. |||. .
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.........gselfgpdalekllekygvdlvl

WAHEHSY
..|.| .
rGHtHkp
subfamily_ACP5_pd Subfamily ACP5 156-359 2.2e-80 261.1 In-house 1-189 (189) alignment 
Range on Protein: 156-359
Range on HMM: 1-189/189.0
IYGDMGNENAQSLARLQQETQRGMYDAIIHVGDFAYDMNTKNARVGDEFMRQIETVAAYLPYMVVPGNHEEKFNFSNYRARFSMPggTENMFYSFDLGPV
..||.|...|.|||.|..|......|.||||||.||....||..|.||||..||..|...||||..||||.. |||.|..|||||  ..|..||||.|||
vfgDlgvseaaslatllkeeeaneldliihvGDlaYalkakneavwdefmnlieplaskvPymvsiGnhesdsnfsaykkrfsmp..sknewYsfdygpv

HFVGISTEVYYFLNyglkplVFQFEWLREDLAKANlpeNRNKRPWIILYGHRPMYCSNENDNDCTHSETLTRVGwpfvHMFGLEPLLYEFGVDVAIWAHE
||...||||...|.        |..||..||..||   ||.|.||||..|||||||||....|||..|||.| |    .. .||.|||...||.|...||
hfislstevdfslg......seqykWLekdLkean...nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkg....lresledllykykvdlalsgHe

HSYE
||||
HsYe
ACP5 158-323 1.9e-09 29.5 In-house 5-178 (198) alignment 
Range on Protein: 158-323
Range on HMM: 5-178/198.0
GDMGNENAQSLA----RLQQETQRGMYDAIIHVGDFAYDMNTKNARVG---DEFMRQIETVAAYLPYMVVPGNHEEKFNFSNYRARFSMPGGTENMFYSF
||.|.... .       ... ...  .|... .||  || ......     ..| .  .  .  .|..|| |||. . | |   .  .    .. . . .
GDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrskdsrfpslry

DLGPVHFVGISTEVYYFLNYGLKPLVFQFEWLREDLAKANLPENRNKRPWIILYGHRPMYCSNENDND-CTHSE
 |   ..|       .  ..  .    . .  .| |.. .   ....  |.|  || |.|   |. .  .  ..
slskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelver
Metallophos_C Iron/zinc purple acid phosphatase-like protein C 383-447 7.5e-26 81.7 Pfam-A 1-62 (62) alignment 
Range on Protein: 383-447
Range on HMM: 1-62/62.0
SAPVHIVTGSAGCkeGREPFKGKIPEWSAFHSQDYGYTRLKAHNRTHIHFEQVSDDkNGAIIDDF
.||||||.|.||.  | ..|. . ||||||...||||.||...||||.|.|.|..| .|...|.|
kApvhIvvGaAGn..glskfskpqpewsafresdyGysrltvvNrthLhwefvrsd.dgqvlDsf