Gene CG11597 in Drosophila melanogaster

Synonym: CG9842, CanA14D, CnA, CnnA14D, D33, DmPp2B-14D, Dmel\CG9842, PP2B, PP2B 14D, PP2B-14D, Pp12-14D, Pp2B-14D/CaN, Pp2B-14DF, PpD33, canA, Dmel_CG9842, Pp2B-14D

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP085_AA protein Get Run
DmelP085_AA_9-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 10-298 7e-105 344.3 In-house 27-325 (473) alignment 
Range on Protein: 10-298
Range on HMM: 27-325/473.0
MNDADRLVENLRHVPvrLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALK
. | |.|.| |.. .  |. | ....|..   ..|  |.||| |. . .|.||||||..|||.|||. |  .| |..||||||||| .|.|...|| |||
lldldlliehlkkeg..llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalk

VRHPAQVSLLRGNHECRSATRSYGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQ
...| .| |||||||.|  .  |||..|.| .| ............. |||||.|.|.||.||||||||.. ||..|...|  |||..|.. |||||||.
ikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPw

EAPG--------WAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQL------LVTIWSAPNYCYRCGNKAAILRLNAAGdYDFKVFE
|  |        .  ||||.| ||| |.|||| . ||. ||.|.|.  ..|....|.        ..|..||||||.|.||.||.|...  . . |..|.
eddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfd

AQA
.  
psp
subfamily_PPP4C_pd Subfamily PPP4C 11-298 1.8e-151 496.3 In-house 1-286 (288) alignment 
Range on Protein: 11-298
Range on HMM: 1-286/288.0
NDADRLVENLRHvpVRLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKV
.|.|| .|.||.  ..| .| ||..||.. ...|| |||. ...||..|||||||||.|||.|...||.|.|..||||||.||||..||||||||.||||
sdldrqieklrr..celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkv

RHPAQVSLLRGNHECRSATRSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE
|.|....|.|||||.|..|..||||.|||..||||||||.|..|||.|.|||||||.|.||||||||....||..||.||..|.|..|...|||||||..
rypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdped

APGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQA
| |||.||||.|.||| ||||.|..||.|.||||||||...|...|| . ..|.||||||||||||.||||.|... |.|||.|||.|
aegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP2C_pd Subfamily PPP2C 12-297 1.7e-109 358.5 In-house 3-286 (290) alignment 
Range on Protein: 12-297
Range on HMM: 3-286/290.0
DADRLVENLRHVpvRLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVR
| |.|.|.|..   .   | ||..||    ..|  |||.  ...|  ||||.|||| ||| |. .||.. .  |||||| ||||  ||||  || |||||
dldklieklkec..kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvr

HPAQVSLLRGNHECRSATRSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEA
.. ....|||||| |  |. ||||.||| .||.||||..   .|| |||.|..|..|.|.|||||| .. ||..|.|||  |.|. | ..|||||||.. 
ykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr

PGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQ
 ||. |||| |  || |. |.| ..||..|| |||||  .|..| . . .|||.|||||||||||.|||| |. . .| |  |.. 
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
0049330 Metallo-dependent phosphatases 14-298 3e-99 325.0 In-house 18-300 (309) alignment 
Range on Protein: 14-298
Range on HMM: 18-300/309.0
DRLVENLRHVPvrLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHP
|.|.| |....  |  | |...|.    ..|  |.|||.|. . .|.||||||..|||.|||. | ..|.|..||||||||| .|.|..||| |||...|
dllielllklk..llseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

AQVSLLRGNHECRSATRSYGFYEECLSRYGsANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQ-EAP
 .| |||||||.|  .. |||..|.| .|| |..|........ |||||.|.|.|||||||||||.. ||..|.|.|  |||. |...|||||||. . .
dnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

GWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQA
|.| .|||.| .|| ..||.| . ||..||.|.|.....|....|.. |.|..||||||.|.||..|.|...  . . |..||.  
gfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
subfamily_PPG1_pd Subfamily PPG1 16-297 3.5e-99 324.9 In-house 4-296 (300) alignment 
Range on Protein: 16-297
Range on HMM: 4-296/300.0
LVENLRHVPVrLPrELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQ
 .|.|... . || |  |..|.  | .||| |||.  ..||  | ||.|||| |.| ....|| | .  |||||| ||||  ||||  || .||.|.|..
cleklqkael.lp.evtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

VSLLRGNHECRSATRSYGFYEECLSRY-GSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQ-----
..||||||| |  |..|||| ||| .| | ..||.    .|| | |||||| .| ||||||||... .|... ||| .|.|. | .||||||||.     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-----EAPG--WAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQ
     .  |  .  |.|| |  .| ||||.| | | .  | |||||...|.. .| ..| |.||||||||||||||.|| |.   .. |.|.|. 
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea
0053225 Metallo-dependent phosphatases 25-296 2.6e-95 312.1 In-house 19-290 (293) alignment 
Range on Protein: 25-296
Range on HMM: 19-290/293.0
VRLPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHE
. |. | |...|.    ..|. |.|||.|. . .|.|||||...|||.|||. | ..| |..||||||||| .|.|...|| |||...| .| |||||||
lkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHE

CRSATRSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEAPGWAASPRGHGKL
..  .  |||..|.| .||.|..|........ |||||.|.|.||.||||||||.  ||..|...|. .||. |...|||||||..  ||. |.||.| .
lmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgwlpsyrglgvv

FGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEA
|| ..|..| ..||. ||.|.||...||....|.. |||..|||||..|.||..|.| |.    ..||.|..
fghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP6C_pd Subfamily PPP6C 27-296 3.8e-117 383.5 In-house 14-283 (290) alignment 
Range on Protein: 27-296
Range on HMM: 14-283/290.0
LPRELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECR
   | ....||  ..|||. |||. ...||  ||||||||| ||..|.  ||.| . .|.|||| ||||  |.||| .| .||...|... |||||||.|
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SATRSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEAPGWAASPRGHGKLFG
  |. ||||.|||..||.||.|. |..|||||..|||||...||||||||||.. ||..| ..|..|||. | ..||.||||..   || |||| | |||
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfg

GDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEA
  |..||.. | ..|||||||| ..|....| . |||.|||||||||||| |.||.|. | . ..|.|.|
skvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfka
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 29-295 2e-88 289.3 In-house 25-292 (298) alignment 
Range on Protein: 29-295
Range on HMM: 25-292/298.0
RELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSA
.| .| .|..   ...   . |. ...|  ||||||||. ||| |.. .|  ... |||||| ||||....|. .|| | ||..| .. |||||||| . 
keedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceai

TRSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGHGKLFGG
 | |||||||  || | ...     ||. |||.|.| | |||.|||||. .. ||.||.| | .. .|. . .||||.||..   |||.. || .  || 
nrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGe

DVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFE
|||....    | |..||||. |||. .  .. ||||.|||.|| .  | ||......     |.|. 
dvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 29-286 6.9e-78 254.9 In-house 25-283 (299) alignment 
Range on Protein: 29-286
Range on HMM: 25-283/299.0
RELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSA
.| |...||.   . .. .. || ...| |||||||||. ||| ...  |   .  .||||| ||||.. .|.  || . |...| .  .||||||| . 
keqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpai

TRSYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGHGKLFGG
 | |||||||  || |. .| .    |. .||. .| . |||.|||||| .| || || | | .. |.  .  ||||.||..   .| |  ||   .|| 
nrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgq

DVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAA
|||..     .| |..||||. |||. .   . ||||.||| || .  | |||....  
dvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvden
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 29-295 4.5e-77 251.9 In-house 7-273 (280) alignment 
Range on Protein: 29-295
Range on HMM: 7-273/280.0
RELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSA
.|... .. .   ..|. .. .. ...|  ||||.|||. ||| |..  .   .. |||||| ||||.  .|  ||| | |||.| .  .||||||. | 
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

TRSYGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQ-EAPGWAASPRGHGKLFGG
 | |||..|.  || | ...     ..| |||.|.. | |||.|||||.... ||||. | |  . ... .  ||||.||. .  |||...||  ..|| 
nrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

DVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFE
.|| ..|.   | ||.| ||. |||. .  .. |||..|||.|.    |.||.|....     |.|. 
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 29-294 1e-76 251.1 In-house 9-280 (284) alignment 
Range on Protein: 29-294
Range on HMM: 9-280/284.0
RELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSV------QEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGN
.| |. .||    .|.  |.  | ...|  ..||||||||||| ||.| |        .|..|||||| ||||  |.|  .|| |.|...| .| |||||
kekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgn

HECRSATRSYGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGH
|| |   . ||||.||  || | ... .    |  .||.|... .|.|.|||.| |.  |..|  |.|  .||. |.|||| |.||..   |.. |||| 
hesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

GKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVF
||.|| . |.||..   . |. ||||. .||. .   . ||||.||| || .  | ||.|...      |.|.
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 29-78 2.9e-10 32.8 In-house 10-59 (317) alignment 
Range on Protein: 29-78
Range on HMM: 10-59/317.0
RELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGG
.| |. .||    .|.  |   |.|..|  ..||||||||||| ||.| |
kekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPP1C_pd Subfamily PPP1C 30-296 9.8e-98 319.8 In-house 12-278 (282) alignment 
Range on Protein: 30-296
Range on HMM: 12-278/282.0
ELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSAT
| |...|...  ..|. .. || |. |  ..||||||..|||.|.| .|. .|..|||||| |||||.|.|| .|| |.|...| .. |||||||. | .
eaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasin

RSYGFYEECLSRYGSAnVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGHGKLFGGD
| ||||.||  ||..  .|..   ||. |||||..| .||||||||||... |...|.. |  |.||.|...|||||||..   ||... ||    || |
riyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkd

VVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEA
|||.| . | ..||.||||. .||....  . |||..|||||| . .|..|.|....    .|... .
vvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_PPZ_pd Subfamily PPZ 30-284 7.4e-70 228.8 In-house 27-281 (300) alignment 
Range on Protein: 30-284
Range on HMM: 27-281/300.0
ELEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSAT
. |. |.|    .|.. . .|| |  .  . ||.|||. |||.|.   |      |||||| |||||.|.|| ||| . |...| .. ||||||||   |
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvt

RSYGFYEECLSRyGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEAP-GWAASPRGHGKLFGGD
| ||||.||  |    ..|.     |. ||||||. |.|.|||||||| .. .|..| . |  ..|. |.| ||||||| ...  |    ||    .   
rvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkv

VVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLN
 ...|    |. |.|||| . .||. .   . |||..||||||    |  |.. ..
ainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvs
PPP_3 31-295 4.8e-103 336.9 In-house 5-270 (271) alignment 
Range on Protein: 31-295
Range on HMM: 5-270/271.0
LEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATR
 |...|...|...|  ||||.....|  ||||||||..|||.| . ||...|..|||||| |||||.|.|..||| |||...| .| |||||||.|. ..
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqink

SYGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADL-LWSDPQEAPGWAASPRGHGKLFGGDV
 |||..|.|...|...|......||.||||||.||...|.|||||||... ||....|.|  |.||.| . || |.|||..  |.. |.|| | ||| ||
vYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdv

VEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFE
.||| ..| ..||.|||.| ..|.. .. . .||..||||||.|..|..|||.|..|  ..||..|
teefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 31-294 1.2e-54 178.6 In-house 9-297 (302) alignment 
Range on Protein: 31-294
Range on HMM: 9-297/302.0
LEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGG-----------SVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLL
 |. .|.... .||  |..|  . .|  . ||||||||||. .|               |  .....|||| ||||..|.|   |. |||| .| .  ||
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHECRSATRSYGFYEECLSRYGSAN---VWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRC-HEIPESGIIADLLWSDPQEA----
|||||...   .||| ||   |.| ..   .|.    ||  .||||..  .|||||||.|| .. |.|.....|  .|. |  .  |||..|| ..    
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

-----PGWAA-SPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVF
     | .|    ||   .|    |... .  ...|| ||||    ||...  . |.||.|||.|     || |.|.... |     |.
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 31-293 2e-54 177.8 In-house 10-297 (302) alignment 
Range on Protein: 31-293
Range on HMM: 10-297/302.0
LEVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGG-----------SVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLL
 |. .|.... .||  |..|  . .|  . ||||||||||. .|               |  .....|||| ||||..|.|   |. |||| .| .  ||
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHECRSATRSYGFYEECLSRYGSAN---VWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRC-HEIPESGIIADLLWSDPQEA----
|||||...   .||| ||  .|.| ..   .|.    ||  .||||..  .|||||||.|| .. |.|.....|  .|. |  .  |||..|| ..    
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqlla

-----PGWAA-SPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKV
     | .|    ||   .|    |... .  ...|| ||||    ||...  . |.||.|||.|     || |.|.... |     |
avsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisv
PP2Ac_SM00156 32-297 1e-96 316.1 In-house 5-270 (271) alignment 
Range on Protein: 32-297
Range on HMM: 5-270/271.0
EVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRS
||..|...  ..|  |.||. ...| .|.||||||..||| ||||.| ..|..|.|||| ||||..|.|. ||| |||...| .| |||||||..| .. 
evlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnki

YGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDP-QEAPGWAASPRGHGKLFGGDVV
|||.||.  .| ..... .. ..|.||||||..| .|||.||||||... |||.|.|.| .|.||.|...||||||| |. .|...| || . .|| |.|
ygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgedav

EEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFKVFEAQ
.|| ..| ..||.|||.. ..|... . . ||||.||||||....||||.|... . .  ......|
keflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 32-282 1e-95 313.0 In-house 5-263 (264) alignment 
Range on Protein: 32-282
Range on HMM: 5-263/264.0
EVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRS
|...|...|..||. |.|||.....  |||||||||.|||.| . ||...|..|||||| |||||.|||..||| |||...| .. |||||||.|. |. 
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv

YGFYEECLSRYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADL--------LWSDPQEAPGWAASPRGHGK
|||..|.| ...|........ |||.|||||.||..||.|||||||... ||. | ..| .|.||.| . ||        |..|.... ..| |.|| | 
ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagy

LFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILR
||| ||.|.| ..|...||.|||.. ..|..... . .|||.||.||.....|..|...
lfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP3C_pd Subfamily PPP3C 32-285 1.2e-78 257.9 In-house 45-311 (452) alignment 
Range on Protein: 32-285
Range on HMM: 45-311/452.0
EVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRS
.. .. .. ..||  |..||....| .|.||||||| |||.|.|.||. .. .|||||| ||||  |.|. | | |||. .| .. |||||||||  |  
aalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhltey

YGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEAPGWAA--------SPRGHGK
. | ||| ..| | .|. .|.. || |||||..... |||||||||... |||...||| .|.|.|| . ||||||| |  | ..        |.||   
ftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsy

LFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFG------QLLVTIWSAPNYCYRCGNKAAILRLNA
...   | || ..| .  | |||.  ..|.| .         .|.|..|||||.    ||||.|... 
fysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 32-291 1.4e-75 247.2 In-house 12-271 (281) alignment 
Range on Protein: 32-291
Range on HMM: 12-271/281.0
EVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRS
|. .. |    ... |..|  ...|  | ||.|.||.|| .|.|| | | |....|||| ||||..|.|...|| .||.|.. .. |||||||  |  . 
eienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki

YGFYEECLSRYGSaNVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGHGKLFGGDVV
||||.||  .||  ..|    | |. ||..| |.  .||.||||||..  ||.||   .  . .. |.. ||||.||.. . .| || || . .|| .||
ygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvv

EEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDF
..  .  .. || ||||. |||..   |. |.|..|.||||    | ||.|..... . ..
ddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgisl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 32-78 1.8e-08 26.9 In-house 15-61 (339) alignment 
Range on Protein: 32-78
Range on HMM: 15-61/339.0
EVRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGG
|. .||.   .|.  |  .| |..|  | |||||||.||| .|.. |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 33-292 1.8e-66 217.4 In-house 11-270 (280) alignment 
Range on Protein: 33-292
Range on HMM: 11-270/280.0
VRQLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSY
.  . | .  ... ||||   ..|  | |||| |..|. .|..| | | | . .|||| |||| . .| ..|| .||.|.  .. |||||||  |  . |
iiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiy

GFYEECLSRYGSANVWRMcCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGHGKLFGGDVVE
||| ||  .|| .  | .   .|. .|....|   .||.||||||..  || .| . |  |  . |.. ||||||| . . ||  | ||   .||  |||
gfyvecqykygvglwwdf.qscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvve

EFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFK
.  ..  | || ||||. |||.    |. |.|..| |||| .  | ||.. |||  .  |.
qacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_PPPLV_pd Subfamily PPPLV 35-281 1.5e-50 165.2 In-house 4-273 (290) alignment 
Range on Protein: 35-281
Range on HMM: 4-273/290.0
QLCRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLH----LLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATR
 ||    | |. | .|| |.||  | ||.||...||      |  .|  .    .||||| ||||. |||    | ||||  |..| ||||||| .| . 
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

SYGFYEECLSRYGSA--NVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLD----RC-HEIPESGIIADLLWSDPQEA------------
|. .. |.  ..|    .||     ||| |||||.|| ...|||.|.   ..    . ...    |  ..|  . .  |.|||||.|             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

PGWAA-SPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCgNKAAIL
 |..  . || | .|. | .| | . |..| . |||.  . |.|   .  |.|..|. .||    |.||..
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaali
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 37-292 2.6e-70 229.6 In-house 19-277 (287) alignment 
Range on Protein: 37-292
Range on HMM: 19-277/287.0
CRSLSDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYE
 . . ..|   . || ...|  ..||||||..|||....  |   . .|||||| |||| .|.|  ||| .||.. | .| |||||||..   . |||.|
lekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfke

ECLSRYGsANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRC--HEIPESGIIADLLWSDPQE-APGWAA-SPRGHGKLFGGDVVEE
|   ...  ....    ||. ||| |...  |||.|||.||... ||.|..| .   .   . |.. ||||.||.. | . .    |.  ..||  .|..
elkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevdd

FTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFK
. .  .|.|| |||.. ..|. . | . |||..||| |. .  | .|.. .. . .  | 
llkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfv
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 41-292 1.5e-62 204.3 In-house 29-284 (290) alignment 
Range on Protein: 41-292
Range on HMM: 29-284/290.0
SDLLVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEEcLS
 ..|     || ...| .. ||||||...||. ..  |   . ..||||| |||| .|.|  |||  .|.|.. .| |||||||.|   | |||.|| | 
eeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkee.la

RYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLD--RCHEIPESGIIADLLWSDPQE--APGWA-ASPRGHGKLFGGDVVEEFTR
|  ....|..   ||. |.| | .. .|||.|||.|....  . |..|   | .   . |.. ||||.||..  .   |    |.   .|| ...... .
rkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllk

ANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDFK
  ..||| |||.. ..|| . | . |||..||| |. .  |  ||...  . .  . 
klalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsiv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 44-284 6e-60 196.0 In-house 36-279 (307) alignment 
Range on Protein: 44-284
Range on HMM: 36-279/307.0
LVGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYG
.  |  |. .. | .| ||.||||.||. .. | |   |  |.| || ||||  |.|. ||| . |. .| .. |||||||     . |||||||..   
fssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsip

--SANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEA-PGWAASPRGHGKLFGGDVVEEFTRANGIS
    ..| .  |.|. ||..|.|  .|||.|||||| .  ||.||   .    |  ||. |.||.||. .   | || || |  || .|...  .  |. 
kcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgve

LICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLN
|| ||||.. ||.    |. |.||.||| ||    |  ..|...
liirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvd
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 45-286 9.2e-70 228.2 In-house 40-284 (297) alignment 
Range on Protein: 45-286
Range on HMM: 40-284/297.0
VGESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYGS
  . ... ...|  ||||||||| |||.|.  ||      |||||| ||||. |.|| .|| | ||. |... ||||||||    . |||||||  || |
kaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqs

ANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDM---QRLDDLRSLDRCHEIPEsGIIADLLWSDPQE-APGWAASPRGHGKLFGGDVVEEFTRANGIS
  ..     ||. |||. .|  .|||.|||||| .     || || ..| .|  | ...|||||.||     |.    || |  || | | .      . 
vrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkld

LICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAA
|.|||||. |||. .  |. ||||.||| || .  | ||..  .  
lvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdek
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 47-287 1.1e-66 218.1 In-house 22-264 (284) alignment 
Range on Protein: 47-287
Range on HMM: 22-264/284.0
ESNLLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYGSAN
.  |.  .||  .|||||||| |||.|..  |  .   |||||| |||||  .|| ||| | ||  | .. .|||||||    . |||||||  ||    
qpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkps

VWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIA-DLLWSDPQE-APGWAASPRGHGKLFGGDVVEEFTRANGISLICR
|.     ||  .||.|..   |||.|||.|  .| . .||.. |  . ||   .| |.||||| .   ||    ||   .|| | . ..     | |. |
vyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvr

AHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAG
|||. |||. .   . ||||.||| || .  | ||.. .|   
ahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 50-291 2.5e-51 167.9 In-house 2-250 (263) alignment 
Range on Protein: 50-291
Range on HMM: 2-250/263.0
LLSLQSPQIVCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYGSANVWR
|| ||.|  .||| |||..|||....  |.  . .|||||| ||||  |.|  .|| .||.  | .. ||||||| ..  . |||. |   |.   .|. 
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

----MCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPES-GIIADLLWSDPQ-EAPGWAA-SPRGHGKLFGGDVVEEFTRANGISLI
       .||  .||.||.   |||.|||.|| .. |||.|..    |  ..  . .||||.||. .| |.     |   ..||   |... .   | ||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGDYDF
 ||||. . |. .   . |.|..||  |     | ||.. .|   .  |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsf
subfamily_PPP5C_pd Subfamily PPP5C 58-297 3.3e-73 239.5 In-house 68-309 (322) alignment 
Range on Protein: 58-297
Range on HMM: 68-309/322.0
IVCGDIHGQFEDLLHLLELGGSV-QEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYgSANVWRMCCRVFD
 ||||||||| ||| ..|| |.. .|. ||| ||.||||  |||. |.| ..|. .| .. | |||||  .  . ||| .|. ..| ...|  .  .||.
tvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfn

LLPLAAIIDGNILCVHGGL-SPDMQRLDDLRSLDRCHEIPESGIIADLLWSDPQEAPGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRW
 |||| .|. ..| ||||| | |   ||||| .|| .. ||.|.. .|||||||||.| ..| || |  || || ..| . |...|| |.|.. ..|.. 
wlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyev

HFGQLLVTIWSAPNYCYRCGNKAAILRL-NAAGDYDFKVFEAQ
.    |.|..|||||| . |||.|...| ..  .  || ||| 
ehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeav
PPP_4 58-248 1.2e-69 227.4 In-house 2-196 (197) alignment 
Range on Protein: 58-248
Range on HMM: 2-196/197.0
IVCGDIHGQFEDL-LHLLELGGSVQ-EHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRyGSANVWRMCCRVF
.|.||||||..|| | ||..||  . |..|.|||| |||||.|.|..||| |||.. |..| |||||||..| .. |||..|.|..  ..........||
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdvf

DLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIP-ESGIIADL-LWSDPQ-EAPGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQL
|||||||.||...|.||||||.....||... ..|  |.| |.. . || |||||. .  |.| | ||.| ||| ||.|.| ..|...||.|.|.|
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 58-248 4.2e-68 222.2 In-house 2-198 (199) alignment 
Range on Protein: 58-248
Range on HMM: 2-198/199.0
IVCGDIHGQFEDL-LHLLELGGSVQ-EHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYGSANVWRMCCRVF
.||||.|||..|| | |.. ||  . |..|.|||| |||||.|.|..||| |||.. |..| |||||||... .. |||..|.||.|...........||
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

DLLPLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIP-ESGIIADL-LWSDPQ-EAPG-WAASPRGHGKLFGGDVVEEFTRANGISLICRAHQL
| |||||.||...|.|||||||... ...|. ..|  ||| |.|  ||| |||||. .  | .. | ||.| ||| ||.|.| . |...||.|.|.|
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
Metallophos Calcineurin-like phosphoesterase 58-247 1.1e-41 136.3 Pfam-A 4-197 (200) alignment 
Range on Protein: 58-247
Range on HMM: 4-197/200.0
IVCGDIHGQFEDL----LHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLL--AALKVRHPAQVSLLRGNHECRSATRSYGFYEECLS-----------
.|.||.||...||    | ||..... .   .||||||||||..| ||. ||   .||.. | .| |||||||.....  |||..|.|.           
lvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeee

----------------------RYGSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRLDDLrsldrcheipesgiiadllwsdpqeapgwaasp
                       ..  .........|..|||.|..||.||..||.||.. .  ||                                  
yenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.................................

rgHGKLFGGDVVEEFTRANGISLICRAHQ
   . ||| |..|.. . .|. |..|.|.
..gselfgpdalekllekygvdlvlrGHt
subfamily_PPP7C_pd Subfamily PPP7C 58-191 8.2e-33 106.6 In-house 67-202 (383) alignment 
Range on Protein: 58-191
Range on HMM: 67-202/383.0
IVCGDIHGQFEDLLHLLELGG-SVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRY--GSANVWRMCCRV
 ||||.||...||| .|   |   .|. |.| ||.|||||.|||  |.| || . .| .| | |||||       |||  |  |.|   .... |.   |
tvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledv

FDLLPLAAIIDGNILCVHGGLSpDMQRLDDLRSLDRC
|  ||||..|| .|| ||||.| |.  |. | ...| 
fawlplatlidekilivhGGis.dktdlelldkiers
subfamily_YNL217W_pd Subfamily YNL217W 58-126 4.1e-08 26.0 In-house 13-77 (235) alignment 
Range on Protein: 58-126
Range on HMM: 13-77/235.0
IVCGDIHGQFEDLLHLLE--LGGSVQEHRYLFLGDLVDRGKNSVETFLLLaalkvrHPAQVSLLRGNHECR
.| ||.|| ...|..||.   ||  ..   ...|||...| .|||.  ..      .  ||  ..||||  
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheel
PPP_2 59-248 9.6e-73 237.1 In-house 3-197 (198) alignment 
Range on Protein: 59-248
Range on HMM: 3-197/198.0
VCGDIHGQFEDLLHLLELGGSVQEHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYGSANVWRMCCRVFDLL
||||.|||..|||.| . |....|..|||||| |||||.|.|..||| |||...| .| |||||||... .. |||..|.|...|...|......||.||
vcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfelL

PLAAIIDGNILCVHGGLSPDMQRLDDLRSLDRCHEIPESGIIADL-----LWSDPQEAPGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQL
||||.||...|.||||||.... ||. .. .|  |.||.| . ||     |......  ..| | || | ||| ||.||....| ..||.|||..
plaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 82-295 2.1e-68 223.8 In-house 100-313 (317) alignment 
Range on Protein: 82-295
Range on HMM: 100-313/317.0
EHRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQR
 ..|||||| ||||  |.|  .|| |||...| .| ||||||| |.  ..||||.|.  || ||... .   .|  |||.|... .|||.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDDLRSLDRCHEIPESGIIADLLWSDPQE-APGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAI
|. |  |.|  .||. |..||| |.||..   |.. |.|| ||.|| . |.||..   . |. ||||. .||. .  .. ||||.|||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

LRLNAAGDYDFKVFE
|...      ..|..
lsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-296 1.8e-52 171.5 In-house 120-333 (339) alignment 
Range on Protein: 83-296
Range on HMM: 120-333/339.0
HRYLFLGDLVDRGKNSVETFLLLAALKVRHPAQVSLLRGNHECRSATRSYGFYEECLSRYgSANVWRMCCRVFDLLPLAAIIDGNILCVHGGLSPDMQRL
.||||||| ||||  |.|  .||.|||. .| .. ||||||| ||   ||||| |   ||  |...     .|...|..|.|.  |.|.|||.|  .  .
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsf

DDLRSLDRCHEIPESGIIADLLWSDPQEA-PGWAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAIL
...  . |  |||. |...|| |.||. .  |.  | ||   .||   .  | .   . .. | ||. .||. .  |. ||||.|||||| .  | ||..
nqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

RLNAAGDYDFKVFEA
 ..       .||  
sidkklkisinvfrp
Kelch_4 Galactose oxidase, central domain 164-189 3e-06 13.5 Pfam-A 10-35 (49) alignment 
Range on Protein: 164-189
Range on HMM: 10-35/49.0
IDGNILCVHGGLSPDMQRLDDLRSLD
.... | ..|| ..|...|.||  .|
vpdgrlylfGGenedggplnDlyvfD
subfamily_PPP7C_pd Subfamily PPP7C 200-288 2.8e-17 55.5 In-house 237-326 (383) alignment 
Range on Protein: 200-288
Range on HMM: 237-326/383.0
IADLLWSDPQEAPG-WAASPRGHGKLFGGDVVEEFTRANGISLICRAHQLAQDGFRWHFGQLLVTIWSAPNYCYRCGNKAAILRLNAAGD
. |.|||||..  | .. . || |  || || ... .  ...|. |.|.  ..|. .   . ..||.|| ||     |. | ..|. .  
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdlt