Gene Pp4-19C in Drosophila melanogaster

Synonym: CG1459, CG1596, CG18339, CG32505, DmPpp4-19C, Dmel\CG32505, PP1, PP4, PP4 19C, PP4-19C, PP4C, PPP4c, PPX, PpX, dPP4, pp4, Dmel_CG32505, Pp4-19C

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP100_AA protein Get Run
DmelP100_AA_2-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 3-293 6.6e-122 400.4 In-house 26-328 (473) alignment 
Range on Protein: 3-293
Range on HMM: 26-328/473.0
DYSDLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKV
...|||. ||.||......|.... |. .|.||| .| |..... ...|.||||||..||..|..  |  || ...|.||.||||..|.|...||||||.
glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalki

RYPDRITLIRGNHESRQITQVYGFYDECLRKYGSTaVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPED
.||....|.|||||.|.....|||.||.|.|||   ..... | ...| |.|.|.|||..|||||||....|||||.|.| .|.|.||...|||||||..
kypgnvfllrGNHElrllnglygfgdetlekyged.lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwe

QTG--------WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNET------VLTVWSAPNYCYRCGNVAAILELNEYLhRDFVIFEA
. |        .| |||||||||| |.| .| . |..|.|.|.|. |.||....|.        ..||.||||||.|.|| ||.|...| | . |..|..
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

APQES
.|.. 
sphpl
0049330 Metallo-dependent phosphatases 4-292 3.2e-113 370.8 In-house 14-302 (309) alignment 
Range on Protein: 4-292
Range on HMM: 14-302/309.0
YSDLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVR
.|.||..||.|... ...|.|.. |. ||.||| .|.|..... ...|.||||||..||..|..  | .|| ...|.||.||||..|.|..|||||||..
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPDRITLIRGNHESRQITQVYGFYDECLRKYGsTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPE-D
|||...|.|||||.|.....|||.||.|||||   .|..... ...| | |.|.|||.||||||||....|||||...| .|.|.||..||||||||  .
ypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpi

QTGWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAPQE
  |.. .|||.|..|| ..| .| ..|..|.|.|.|..|..|....|.. ..||.||||||.|.||..|.||..| | . |..||..|..
regfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_PPP4C_pd Subfamily PPP4C 5-292 3.7e-184 603.5 In-house 1-288 (288) alignment 
Range on Protein: 5-292
Range on HMM: 1-288/288.0
SDLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRY
||||||||.|.|||.|||.||||||||||||||||.||||||||||||||||||||||.|||||||||||.||||.|||||||.||||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQT
||||||||||||||||||||||||||||||||..|||||||.||||||.||||||||||||||||||. ||.||||||||||||.||.||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAPQE
||.|||||||||||||||.|||..|||..|||||||||||.|.||||.|||||||||||||||||||||||.| |..|| |||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 5-292 6.1e-156 510.9 In-house 2-289 (290) alignment 
Range on Protein: 5-292
Range on HMM: 2-289/290.0
SDLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRY
.|||..||.||.|. ..|.|||.|| ||.||| .| ||| | .|||||||.||||.|| ||||.||..|. ||||.||.||||||||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQT
..|||..||||||||||||||||||||||||...||.| |..||||.|.|..|..|||.||||||||. ||.||..|| |||||.||.||||||||.|..
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAPQE
|||.||||||| || |.  .||.||.. .| |||||||||..| ... | |..||||||||||| ||||||.. |.. |. |..||..
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
0053225 Metallo-dependent phosphatases 5-290 1.2e-109 359.1 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SDLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRY
..||..||.|... ...|.|.. |. .|.|||..|.|..... ...|.|||||...||..|..  | .|| ...|.||.||||..|.|...||||||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQT
||...|.|||||.......|||.||.|||||. ..|..... ...| |.|.|.|||..|||||||.. .|||||.|.| ...|..|...||||||| . .
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAP
||. |.||.|..|| ..| .| ..|..|.|.|.||.|..|....|.. ..||.|||||..|.||..|.|.|.| | ..|..|.. .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP6C_pd Subfamily PPP6C 6-294 9.9e-151 493.8 In-house 1-289 (290) alignment 
Range on Protein: 6-294
Range on HMM: 1-289/290.0
DLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYP
.||. ||. |.|. . ||..|.||..  ..|.||.||| | ||||||||||||||||.|||. ||.||...|.|.||||||||||.||| .||.||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQTG
|||||.||||||||||||||||||||.|||....|.|||..|| |...||||....|||||||| .. ||||| |.| ||.||.|..|||.||||||   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAPQESR
| |||||||||||| |...|...|....||||||||.||.|..|.| . ||||||||||||||||.||.|..  .|.. .|.| |.| |
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP7C_pd Subfamily PPP7C 6-184 5.7e-39 126.9 In-house 19-203 (383) alignment 
Range on Protein: 6-184
Range on HMM: 19-203/383.0
DLDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDS----PVTVCGDIHGQFYDLKE-LFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLAL
.... ||..|. .... . |  .  .|...|..  |..|| .     ||||||.||.. ||   |.| |   .|..|.| |||||||  |||  |.||||
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KVRYPDRITLIRGNHESRQITQVYGFYDECLRKY--GSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQyLDQIRSIDRKQ
 . ||  . | |||||   .   |||  |   ||   .. . |   ..| .| |...|| ||. ||||.| . . |. . .|.|..
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiersk
subfamily_PPG1_pd Subfamily PPG1 7-292 3.6e-135 443.0 In-house 1-299 (300) alignment 
Range on Protein: 7-292
Range on HMM: 1-299/300.0
LDRQIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPD
||. .|.|...|.. |  ||.|. | .|.||.| ||... ||||| ||.||||||. |.||.||.||. ||||.||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYDECLRKY-GSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPE----
||||.|||||||||||||||| |||||| | . ||.| |||||||.|.|||| .|.|||||||||.. .|||. .|| .|||..| ..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DQTG--WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAPQE
      |. |  . ||.||||| .| ||| .| |.||.. | |||||..||.. .|.. . |||||||||||||| |.||||.| ..| | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-289 6.2e-95 310.6 In-house 14-294 (298) alignment 
Range on Protein: 10-289
Range on HMM: 14-294/298.0
QIEQLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRIT
 ... | ...|||..|. |...|..|. .   .  ||.|..||||||||. ||  ||. .|  |..||||.||.|||| ...|. .|||| ||.||... 
slsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnff

LIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPED-QTGWGV
|.|||||  .| .|||||.|| |.| |....    ..|. | | |.| |.|.|.|||||. .. |||.|.. | .. ...    ||||.|||. ..||  
llrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwae

SPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAA
. ||... ||.||| ..  . |||...||||.| .|...  .  ..|..|||.|| .  | ||.....| |   |...  .
nsrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPP3C_pd Subfamily PPP3C 13-277 3.2e-85 279.6 In-house 34-311 (452) alignment 
Range on Protein: 13-277
Range on HMM: 34-311/452.0
QLKRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIR
 ...   ..|...  .  .| ..| .| .. .|..|.||.|||||||||| .||.||||  . .|||.||.|||||.|.|. | |.|||. ||... |.|
hflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllr

GNHESRQITQVYGFYDECLRKYgSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQTGWGV----
||||.| .|. . | .||  || | .|.  |.| || | |.|..... .|||||||| |. ||.|...|| .|.|. ||.|||||||| .. |       
Gnhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteek

----SPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFN------ETVLTVWSAPNYCYRCGNVAAILELNE
    |.||  |...   |..| ..||.  | |||.   .|.. . .       ...|..|||||.    | ||.|....
fvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 14-289 1.5e-83 273.2 In-house 2-275 (280) alignment 
Range on Protein: 14-289
Range on HMM: 2-275/280.0
LKRCeiIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRG
| .|  ||| .....  | ..||. .  .  ||.||.||||.|||. ||  ||.  .  |..||||.||.|||| . .|  ||||| |||||... ..||
llac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrg

NHESRQITQVYGFYDECLRKYgSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPE-DQTGWGVSPRG
|||  .| . |||.||. |.| | |..    |..| | | |.. |.|.|.|||||. .. ||... . |  . ...    ||||.||| ..|||. ..||
nhevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrg

AGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAA
. ..||..|| .. .  |||.|.| ||.| .|...  .  ..||.|||.|.    | ||.| ..| |   | ..  |
vsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 15-286 8e-73 238.3 In-house 18-292 (297) alignment 
Range on Protein: 15-286
Range on HMM: 18-292/297.0
KRCEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGN
  ...| |. |  |   | ...  . ..  |..|. ||||||||| ||  ||. ||  |  ||||.||.|||| .|.|| .|||| ||..|  . |.|||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSP---SIQYLDQIRSIDRKQEVpHDGPMCDLLWSDPED-QTGWGVSP
||   . .|||||.|| ..| |  ..    ..|..| |. .|  ||.|.||||||       || .| |.| .|  ... ..||||.||    .|.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIF
||||  || | | .     ..|..|||||.| .|...     ..|..||| || .  |.||..  .| |.  | |.
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeil
subfamily_PPP5C_pd Subfamily PPP5C 17-290 5.9e-83 271.5 In-house 31-310 (322) alignment 
Range on Protein: 17-290
Range on HMM: 31-310/322.0
CEIIKENEVKALCAKAREILVEEGNVQRVD----SPVTVCGDIHGQFYDLKELFKVGGDVPE-KNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLI
 . ...  . .. ..|.|.| ..  .  ..    . .||||||||||||| ..|.. | . | . ||| ||||||| .|||. |.||..|. ||... | 
qkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhffls

RGNHESRQITQVYGFYDECLRKYGStAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPS-IQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQTGWGVSP
|||||| .. ..||| .|.  || . .|    ||.|..| |. .|. |.. |||||  .    ||..| ||| .. |..| ...||||||....| . | 
rGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspsk

RGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILEL-NEYLHRDFVIFEAAP
|| |  || || ..| ..|....| |.|.. .||.. . .  ..||.|||||| . || .|...| .. |.  |  ||| .
rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-283 4.5e-73 239.1 In-house 3-269 (280) alignment 
Range on Protein: 17-283
Range on HMM: 3-269/280.0
CEIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHE
|...   |. |.      |..|| |.   ..|. | |||| |. |.. || . | |||.. .|.||.||||   .| ..||..||.|| ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGSTAVWRYCTeIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ-TGWGVSPRGAGY
.  . ..|||| ||  |||    | . . .|. . .|..|  ...|.|||||| .  || || | |  |    | . ||||||| ..  ||  | ||  |
tpsvnkiygfyvecqykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDF
.||  || |  .. .||.| ||||.| .|..      ..||.| |||| .  | ||.. ||  |.  |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsf
subfamily_PPP1C_pd Subfamily PPP1C 18-288 3.7e-107 350.7 In-house 8-278 (282) alignment 
Range on Protein: 18-288
Range on HMM: 8-278/282.0
EIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHES
  .||.|..||..||||||...  . ... ||...||||||..||  ||. .|  ||.||||.||.||||  |.|| .||||.|..||... |.||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGSTaVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPED-QTGWGVSPRGAGYL
 .|...||||||| |.|... .|.  |..|..| |.|..| ||.||||||||... |.|||.| |  |||..| .||||||||.. ..||. . ||  . 
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEA
||.|||..| . ||.|.|.||||.| .|.... .. ..||.|||||| . .| .|.|...| |  .| |. .
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-292 1.2e-84 277.0 In-house 22-297 (299) alignment 
Range on Protein: 18-292
Range on HMM: 22-297/299.0
EIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHES
. .||.|.. ||| |.......  .  |..|. ||||||||. ||  .|.. |  |. |.||.||.||||   .|.  |||. |..||.|. ..||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ-TGWGVSPRGAGYL
  | .|||||.|| ..| || .|    . |... |. .| ..|.|.|||||| .| |||.| . | |. |      ||||.||..   .|    ||  |.
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAPQE
|| |||..   . |||...||||.| .|...  .  ..|..||| || .  | |||....| |   ||... .|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-287 1.5e-81 267.0 In-house 6-281 (284) alignment 
Range on Protein: 18-287
Range on HMM: 6-281/284.0
EIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDV------PEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLI
...||.|.  || .|||.. .|   . ...||...||||||| ||. |... |         ||.|||.||.|||| .|.|  .||.|.|...||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECLRKYgSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ-TGWGVSP
||||||| . . |||| || ..| |.|..      |  . |.|... ||.|.|||.|  .  |.|.  ..|  ..|  | ..|| |.||| . .|.  ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFE
|||| .||.. | .|... ..|.. ||||.||.|...  .  ..|..||| || .  |.||.|...| |   |....
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 18-288 2.3e-80 262.9 In-house 5-276 (281) alignment 
Range on Protein: 18-288
Range on HMM: 5-276/281.0
EI-IKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHE
.. . ..|....  ... |..|| ..  .|.|..| ||.|.|| |||.||.. | |||. ..|.||.||||  |.|...||..||.||.||| |.|||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

SRQITQVYGFYDECLRKYGStAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ-TGWGVSPRGAGY
  .. ..|||| ||  |||   .|    . |. | .|| |. .. |.|||||| .  ||..| . .  . .. | . ||||.||...  .|  | ||...
iasvnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

LFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEA
.|| .|| .  .. ....| ||||.|..|..      ..||.|.||||    | ||.| ..| |  ..| .  
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 18-287 8e-73 237.8 In-house 8-280 (287) alignment 
Range on Protein: 18-287
Range on HMM: 8-280/287.0
EIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHES
. ......  .  |..|||     . .|..|.|..||||||. ||  .|.  |  |. .|||.||.||||  |.|  |||..||..|| .. |.||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGsTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQE--VPHDGPMCDLLWSDPEDQ-TGWGV-SPRGA
..| ..|||..|  ||..   ...   ..|..|.| |... .|.|.|||.|| .. ||..... . .     ..| . ||||.||| .  .  .   |. 
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

GYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFE
  .||  .| .. .. |||.| |||... ||... |.. ..||.||| |. .  |..|.. ... |.  || . 
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 18-286 1e-64 211.3 In-house 14-286 (290) alignment 
Range on Protein: 18-286
Range on HMM: 14-286/290.0
EIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHES
. ......  .  |..|||     . .| .|... ||||||. .| . |.  |  |. ..||.||.||||  |.|  |||. .|.||. .. |.||||| 
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

RQITQVYGFYDECLRKYGStAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQ--EVPHDGPMCDLLWSDPED---QTGWGVSPRG
|.. ..|||..|  || ||  .|.   ..|. ||| | .. ||.|.|||.|. |.  . .... . .     ..| . ||||.||.    .|      |.
rkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

AGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIF
   .|| ... .. ..  ...| |||..  |||.. |.. ..||.||| |. .  |. ||... | |.  .|..
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-70 1.6e-13 43.5 In-house 7-59 (317) alignment 
Range on Protein: 18-70
Range on HMM: 7-59/317.0
EIIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGG
...||.|.  || .|||.. .|    ....|||..||||||| ||. |... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPZ_pd Subfamily PPZ 19-286 6.7e-77 251.9 In-house 24-291 (300) alignment 
Range on Protein: 19-286
Range on HMM: 24-291/300.0
IIKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESR
 .|..|.  .| ||||... . ..  .  .| . ||.|||. ||  ||   |  |  ||||.||.||||  |.|| ||||. |..||. . |.|||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECLRKYgSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQT-GWGVSPRGAGYLF
..|.|||||||| |.     .|.   . |. | |.||. |||||||||||| .. .|.|| . |  .||  | . ||||||| | .  |    ||  | .
nvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIF
    . .|     .|..|||| .| .|...  . ...||.||||||    |  |.. ..| |   | ..
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfell
PPP_3 20-287 3.1e-121 396.5 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
IKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQ
..|||.| |. |..||| .| |......|||||||||||..|| ||||.||..||..|||.||.||||..|.|..|||||||..||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDL-LWSDPEDQTGWGVSPRGAGYLFG
|..||||..|.|.|.|.. |.....|.|..|.|.|.||.|...|||||||||. ||||....||.|||..|...|| |.||||...|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFE
.||...|...|....|.|||.|..||.. .... |.||.||||||.|..|..|||.|.| |...|...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 20-287 1.2e-71 234.5 In-house 3-272 (284) alignment 
Range on Protein: 20-287
Range on HMM: 3-272/284.0
IKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQ
|  ..|..|  .| .|. ..  .  |.||. .|||||||| ||  ||   |     ||||.||.|||| . .|| |||.| || .|... ..|||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPM-CDLLWSDPED-QTGWGVSPRGAGYLF
| ..||||.|| |.|   .|.     .|  . |.|..  .|.|.|||.|  .| . |.|.| |  . |    .  |.||||| . | ||    ||  |.|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFE
||| . ..    .||.. ||||.| .|...  |  ..|..||| || .  | ||.. .|. |   ||.. 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 20-290 6e-61 199.3 In-house 21-293 (307) alignment 
Range on Protein: 20-290
Range on HMM: 21-293/307.0
IKEnEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQ
 || |.. .  .|. |.  |  .  .| |. | ||.|||| || ..| . |  ||  |.| ||.||||  |.|. |||.. |. ||. | |.|||||  .
tke.efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiar

ITQVYGFYDECLRKYG--STAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ-TGWGVSPRGAGYL
. . ||||.||.         .|      |. | .||.|  ||.|.||||||..  ||..|   .    |  | . |.||.||.     |  | ||.|. 
vnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgft

FGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAP
||..|. .  .   ...| ||||....|.       ..|..||| ||    |  ..| ..| |  . | |  . 
fgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-276 1.5e-52 171.7 In-house 6-287 (302) alignment 
Range on Protein: 20-276
Range on HMM: 6-287/302.0
IKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFK-----------VGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRI
 ...|. .|. .  | | .| .. .. .|||. ||||||| ||  ...                 .. ..|.||.||||. |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLRKYGSTA---VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRK-QEVPHDGPMCDLLWSDPEDQT
 |.|||||.. |   ||| .|   ..| .    .|.   |.| .. |.|..  ||.|||||.|| .. |..|..|.|  .|| .|    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVS----------PRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELN
.  .            ||  ..|    | .. .  ....| |||| . ||||.. .. .||..|||.|     |  |.|...
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-276 2.1e-52 171.2 In-house 7-288 (302) alignment 
Range on Protein: 20-276
Range on HMM: 7-288/302.0
IKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFK-----------VGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRI
 ...|. .|. .  | | .| .. .. .|||. ||||||| ||  ...                 .. ..|.||.||||. |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLRKYGSTA---VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRK-QEVPHDGPMCDLLWSDPEDQT
 |.|||||.. |   ||| .|   ..| .    .|.   |.| .. |.|..  ||.|||||.|| .. |..|..|.|  .|| .|    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVS----------PRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELN
.  .            ||  ..|    | .. .  ....| |||| . ||||.. .. .||..|||.|     |  |.|...
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 20-69 2.6e-08 26.3 In-house 11-60 (339) alignment 
Range on Protein: 20-69
Range on HMM: 11-60/339.0
IKENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVG
.   |.  || .|||..  |  . ....|. | ||||||| ||  .. . 
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmn
PPP_1 21-274 3.4e-115 376.8 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
KENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQI
.|.|...|. |..|.|..| |...|....||||||||||.|| .||||||..||.||||.||.||||..|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLL--------WSDPEDQTGWGVSPRG
|.||||..|.|.|..|. .....|..||.|.|.|.||.||..|||||||... ||||| ..||.|||..|..||||        ..|.|.....  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILE
||||||.||...|...|....|.|||....||........|.|..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 21-288 7.9e-106 346.0 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
KENEVKALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQI
...||..|. ...||| .| |. .|..||||.||||||..|| .|.. .| .||..|.|.||.||||..|.|. |||.|||..||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDP-EDQTGWGVSPRGAGYLFGS
...|||..|. ||| .. ..  ..|.|..|.|.|..| ||.|.||||||... ||.||...| .| |..|...||||||| ... |.  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEA
|.|..| ..|....|.|||..|.||... ... ..|..||||||....|.||.|.... |.  .. ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPPLV_pd Subfamily PPPLV 26-273 8.9e-55 179.0 In-house 3-274 (290) alignment 
Range on Protein: 26-273
Range on HMM: 3-274/290.0
KALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDL----KELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQIT
 .|| .| .||..| ..  ..||. | ||.||.. ||    | |...| |.   ..||.||.|||| .|||    |||||| || .. |.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGST--AVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQ---YLDQIRSIDRKQEVPHDG-PM-CDLLWSDPEDQT----------
. . .. |.  |.| .   ||   ...||.| |.|.|| |.||||.|.  .|.   |.  |. |  . . . || |.  |.|||||...           
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GWG-VSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAIL
  |.   . || |..|..| . .| . |... . |||.   .|..   .  .|||.|. .||    . | ||
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalil
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-288 1.5e-55 181.7 In-house 5-255 (263) alignment 
Range on Protein: 45-288
Range on HMM: 5-255/263.0
VDSPVTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGST----AVW
...|. .||| |||. ||  .|.  |   . .|||.||.|||| .|.|  .||..||.  | .. |.||||| . | . |||. |  ...       .|.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

RYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPM-CDLLWSDPEDQTgWGVSP---RGAGYLFGSDVVSQFNRTNDIDMICR
 .  ..| |. | ||.  .|.|.|||.|| .. ||.||.|    |  .  |. |||||.||| ..  |. |   |    .||   | .. .  |||.| |
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekda.kgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEA
|||.|  |. .  .  ..||.||  |     | ||.. .|. |   || .. 
ahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 48-240 3.4e-48 157.6 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----KELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLL--LALKVRYPDRITLIRGNHESRQITQVYGFYDECL----------
...|.||.||...||     .|.|.... .  ..||.||.|||| .| ||. ||  |.||...|... |.||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIrsidrkqevphdgpmcdllwsdpedqtgwgv
                       .... . ..... |.|..|.| |..||||...||.||.| .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYLFGSDVVSQFNRTNDIDMICRAHQL
    ...|||.|... . . ...|...|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 1.7e-83 272.2 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLKELFKVGGDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEIFD
||||||.|||..|| .|||.|...||..|||.||.||||..|.|..|||||||..||....|.||||||.....||||..|.|.|.|...|.....|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDL-----LWSDPEDQTGWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQL
.|.|.|.||.|...||||||..|. ||||....||.|.|..|...||     |....|.....  | ||||.|||.||.... ..|....|.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 5.9e-79 257.7 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-KELFKVGGDVP-EKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKyGSTAVWRYCTEI
|||.||||||..||  .|.|.||. . |..|.|.||.||||..|.|..|||||||..||....|.||||||......|||..|.|.|  .  ........
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVP-HDGPMCDL-LWSDPE-DQTGWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQL
||.|.|.|.||.|...||||||.... ||.|. |.||.|.| ... ..|| |||||. .|.|.  | ||||.|||.||...| ..|....|.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 7.3e-78 254.1 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-KELFKVGGDVP-EKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSTAVWRYCTEI
||||||.|||..||  .||| ||| . |..|.|.||.||||..|.|..|||||||..||....|.|||||..|....|||..|.|.||..  ........
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVP-HDGPMCDL-LWSDPE-DQTG-WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQL
||.|.|.|.||.|...|||||||.|. ..... |.||.|.| ..| ..|| |||||. .|.| .  | ||||.||| ||...| ..|....|.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 74-287 3e-69 226.6 In-house 100-313 (317) alignment 
Range on Protein: 74-287
Range on HMM: 100-313/317.0
EKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYgSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQY
 |.|||.||.|||| .|.|  .||.|||..|||...|.||||||| . . |||| |. ..| |.|..     .|  | |.|... ||.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ-TGWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAI
|.|.  ..|  ..|  | ..|| |.||. . .|.  |.|||| .||.. | .|... |.|.. ||||.|..|...  .  ..|..|||.|| .  |.||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

LELNEYLHRDFVIFE
|.... |.  . ...
lsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 75-287 3.8e-53 173.8 In-house 120-332 (339) alignment 
Range on Protein: 75-287
Range on HMM: 120-332/339.0
KNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGStAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYL
| |||.||.|||| .|.|  .|| |||. ||||| |.||||||| .   |||| |   .| .  ..    ..|. . . |.|.  |.|.|||.|  .  .
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsf

DQIRSIDRKQEVPHDGPMCDLLWSDPED-QTGWGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAIL
.|.  . |  |.|  | . || |.||.  . |.  | ||| ..||   .  | .  |..|. | ||.| .|...     ..|..|||||| .  | ||..
nqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

ELNEYLHRDFVIFE
 ... |.    .| 
sidkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 192-291 1.5e-19 63.0 In-house 237-337 (383) alignment 
Range on Protein: 192-291
Range on HMM: 237-337/383.0
MCDLLWSDPEDQTG-WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNETVLTVWSAPNYCYRCGNVAAILELNEYLHRDFVIFEAAP
. |.|||||. ..| .  . ||.|  ||.|| ... .  ..... |.|.  .||...  ...|||..|| ||     |  | . |.. |.  .| . |. 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask

Q
.
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