Gene rdgC in Drosophila melanogaster

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP103_AA protein Get Run
DmelP103_AA_179-560 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
IQ IQ calmodulin-binding motif 92-110 4.9e-07 18.6 Pfam-A 2-20 (21) alignment 
Range on Protein: 92-110
Range on HMM: 2-20/21.0
RAAIFIQKWYRRHQARREM
.||| ||...|...||.. 
kaaikIQaawRgylaRkry
subfamily_PPP7C_pd Subfamily PPP7C 179-545 5.2e-186 610.9 In-house 9-383 (383) alignment 
Range on Protein: 179-545
Range on HMM: 9-383/383.0
AKIELPIRKNHIDLLIDVFRKKRgnRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGK
 ...||..|.... ||..|..|.  .||.|||.||||||.|.|||||||| ||||.|..|||||||||||||||..|.||||||..||||||||||||||
prlslpltkdeveklieafkekk..llhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGk

RGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVS
...|.||.||.|.|..|..|.||||||||...|.|||||.||||||....|.||.....|..||||........||||||.||.|.|.|...|.| |.||
esveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkiersklvs

ILRPPLTDGE-----------PLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSAS
.|||||..||           ..||.||.|..||.||||.|..||.||||||.|..||||||...||...|...||||||||.|.||.||.|..||||||
vlrpplkegeeaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsas

NYYAIGSNKGAYIRLNNQLMPHFVQYISAaSQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGY
|||..|||.|||..|...|.|..|||... ..||.|...||..|||.|||.||..........|..||.|.|.|.||.
nyyeeGsnrGayvklgkdltprivqyqas.katkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksgl
0045823 Metallo-dependent phosphatases 180-560 9.8e-91 297.7 In-house 20-388 (473) alignment 
Range on Protein: 180-560
Range on HMM: 20-388/473.0
KIELPIRKNHIDLLIDVFrkKRGNRLHPKYVALILREAAKSLKQLPNISPVSTavsqQVTVCGDLHGKLDDLLVVLHKNGLPSSsNPYVFNGDFVDRGKR
..  .. . ..||||. .  |....|.....  .|.||.. ||. ||. ..|      ..|.||.|| ||||| .|.|.|.|.. . .||.||.||||  
llfillglldldlliehl..kkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflGDlvDrGpd

GLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNhkrILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGKYVS
.||||.|||.| ...|. ||| |||||. ..|. ||| .|.  || ..   .   . |. |.|||  |.....|.|||| |.. ..|| |..|.|  ...
slevlelllalkikypgnvfllrGNHElrllnglygfgdetlekyged...lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleip

IlrppltdgepldkteWQQIFDIMWSDPQATMGC-------VPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNK------IITIFS
                .....|..||||. ..|.        .|..||||..||||....||... | ...|.|.. |.|.|...|.|       ||.||
d...............dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfS

ASNYYAIGSNKGAYIRLNNQLmPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTK
|.||.  | |..|.......| ..|.|.  .    ..  | . . .. .  |..|.  .. .   ..|..   |.. .|.. .........|...
ApnYcgrggnlaAvlvidedl.isfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededilglllleallellrnkil
0049330 Metallo-dependent phosphatases 180-494 3.3e-77 252.6 In-house 7-297 (309) alignment 
Range on Protein: 180-494
Range on HMM: 7-297/309.0
KIELPIRKNHIDLLIDVFRKkrGNRLHPKYVALILREAAKSLKQLPNISPVStavsQQVTVCGDLHGKLDDLLVVLHKNGLPSSsNPYVFNGDFVDRGKR
 . |.. ....||||. ..|  . .|. ... |.| .| . ||. ||. ..|      ..|.||.|| ||||| .|.|.|.|.. . .||.||.||||  
llllelilslldllielllk..lkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpd

GLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPrnhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDST-SLDLIKSIDRGKYVS
.||||||||.| |..|. ||| |||||. ..|. ||| .|.  ||     ..   . ...|.|||  |.....|.||||.|..  .|| |....|  .. 
slevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkyg...aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleip

ILRppltdgepldktewqQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGA
  .                ..|..||||. .    ..  ||.||.||......||... |...||.|.. ..|.....|.|.||.|||.||.   .|.||
ldg...............llcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlga

YIRLNNQLMPHFVQYI
.......|...|... 
vleidedlvisfllfe
subfamily_PPP5C_pd Subfamily PPP5C 185-493 3.1e-85 279.0 In-house 16-306 (322) alignment 
Range on Protein: 185-493
Range on HMM: 16-306/322.0
IRKNHIDLLIDVFRKKrgNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVL
| |. .. |.. |.|.  ..|| ||.. || || . ||.|| .  ...  ....|||||.||.  ||| ....|||||..|||.|||||||||   .||.
itkefvkellelfkkq..kklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevi

LLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPrnhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFS--DSTSLDLIKSIDRGKyvsilRP
|.||.. | .|| .||.||||| . ||  |||  ||..||    .... .  ||. ||||. |.|..||.||||.   |. .|| .. ||| .     .|
ltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyt...ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrna.....qp

PlTDGepldktewqQIFDIMWSDPQATMGCVPNtLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRL
| ..|         .. ...||||| ..|  |   || || ||||||..||.  .|...||||| | .|.|..|| |.||.||| ||    .||||.|.|
p.eeg.........llvellwsdpqeanGrsps.krGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitl

-NNQLMPHFVQY
 ...| ..| ..
rgddlklkfktf
0053225 Metallo-dependent phosphatases 187-494 3.4e-72 236.3 In-house 6-289 (293) alignment 
Range on Protein: 187-494
Range on HMM: 6-289/293.0
KNHIDLLIDVFrkKRGNRLHPKYVALILREAAKSLKQLPNISPVStavsQQVTVCGDLHGKLDDLLVVLHKNGLPSSsNPYVFNGDFVDRGKRGLEVLLL
. ..||||...  ..  .|. ... |.| || . ||. ||. ..|      ..|.||.|| ||||| .|.| |.|.. . .||.||.||||  .||||.|
lllldlliell..lllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlel

LLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPrnHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSD-STSLDLIKSIDRGKYVSilrpplt
||.| | .|. |.| |||||. ..|. ||| .|.  ||   ....   . ...|.|||  ......|.||||.|.  ..|| |..|.|  ..        
llalkllypdnvvllrGNHElmllnglygfgdetlrkyg..aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip.......

dgepldktEWQQIFDIMWSDPQATMGCVPNtLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQ
        ... ..|..||||.  .|..|.  ||.||.||......||... | ..||.|.. |.|.....|.|..|.|||.||.   .|.||.. |...
........legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg

LMPHFVQYI
|...|... 
lvwgfklfa
subfamily_PPP3C_pd Subfamily PPP3C 189-487 8.9e-49 159.5 In-house 27-314 (452) alignment 
Range on Protein: 189-487
Range on HMM: 27-314/452.0
HIDLLIDVFRKKrgNRLHPKYVALILREAAKSLKQLPNIspvsTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLL
....| . | |.   ||. . .. |..|||| ||. ...      |.  .||.||.||.  ||| ... .| |.|.. |.| ||.||||   .|..| |.
klevlkehflke..grleeeaalkiieeaakllkkektl....leveaPitviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlyly

SLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYprnHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGKYVSILrppltdG
.| .|.|. .|| |||||   .   . | .|...||    ...   . | .  ||| ..|| . | ||||.|   .||| ||..|| | .         |
alkiaypstlfllrGnhecrhlteyftfkeeckiky...seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppas......G

epldktewqQIFDIMWSDPQ-------ATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDN------KIITIFSASNYYAIGS
          . |..||||        ..   |||. ||  ....   . .|||.  |  .||.||.. .|..  ...       .||.|||.||  . .
.........plcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvyn

NKGAYIRLNNQLM
||.| ....|. |
nkaavlkyennvm
subfamily_PPP2C_pd Subfamily PPP2C 200-498 1.2e-49 162.1 In-house 12-288 (290) alignment 
Range on Protein: 200-498
Range on HMM: 12-288/290.0
KRGNRLHPKYVALILREAAKSLKQLPNISPVSTavsqQVTVCGDLHGKLDDLLVVLhKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVF
|....|. . |. .  .| . |..  |. .|..     ||||||.||.. ||| .. | |  |    |.| ||.||||   .| . || .| . ... . 
keckqleesevkelcekakeilskesnvqevkc....pvtvcgdvhgqfhdllelf.kiggkspdtnylflgdyvdrgyysvetvtllvalkvrykerit

LNRGNHEDSVMNARYGFIREVESKYPRnhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGKYVsilrpPlTDGepldktewqQI
. |||||   .   |||  |.  ||      .  .. ... .||| ........ .|||.| | ..|| |...|| . |     |  .|          .
ilrgnhesrqitqvygfydeclrkygn..anvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqev.....p.heg.........pl

FDIMWSDPQATMGCVpNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAAS
 |..||||.   | .  . ||||  || |....| ..  |....|.|.   .|....||....||||| ||     |..| . |...|  .|.|. .|. 
cdllwsdpddrggwg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP1C_pd Subfamily PPP1C 205-491 1.2e-64 211.2 In-house 10-274 (282) alignment 
Range on Protein: 205-491
Range on HMM: 10-274/282.0
LHPKYVALILREAAKSLKQLPNIspvsTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGN
|. . .  .|..| . |.. | .      ... |...||.||.. ||| .....| |..|| |.| ||.|||||..||...|||.. . .|. .|| |||
lkeaeieallkkareillsqpil....leleaPvkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGn

HEDSVMNARYGFIREVESKYPRNhkrILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGKYVSILrppltdgepldktewQQIFDIMW
||.. .|. |||  |.. .|  .   .   . .|. .||| .......| ||||.| . .||. |..| |   |.                   . |..|
hesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpek...............gllcdllW

SDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFV
|||. ..  . .  ||  . ||.|| ..|||.. |. ..|.|..  .|.||. .....|.|||.|| .   |.|| ......|. .| 
sdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
PP2Ac_SM00156 206-494 1e-96 316.1 In-house 2-268 (271) alignment 
Range on Protein: 206-494
Range on HMM: 2-268/271.0
HPKYVALILREAAKSLKQLPNISPVStavsQQVTVCGDLHGKLDDLLVVLHKNGlPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNH
....|. .|.|... ||| .|.  ||    ..|||.||.||.||||| .|...| ......|||.||.||||....||.|||..|....|. |.|.||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

EDSVMNARYGFIREVESKYprnHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFS-DSTSLDLIKSIDRgkyvsilrppltdgePLDKTEWQQIFDIMWS
|.| .|  ||| .||. ||   .|.|.. ..|....|||.....|..|..|||.| ...||| |....|               . .|.|.....|..||
Esssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr...............vkekpeegllidllws

DP-QATMGCVPNTlRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYI
|| | ..|. |.. ||..|.||.|....||....|...||.||....|.||..|.|..|||||.||..  |||.|.......|.....|. 
dpeqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 209-492 5.5e-57 186.1 In-house 28-290 (298) alignment 
Range on Protein: 209-492
Range on HMM: 28-290/298.0
YVALILREAAKSLKQLPNIspvsTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDS
 |  ....| | .|. . .      |   ..||||.||.  ||| ...|.| | ..| |.| ||.||||.  |||..|||.  . .|| .|| ||||| .
dveklielakkifkkqksl....vevdapikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhece

VMNARYGFIREVESKYprNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDStsldlIKSIDRgkYVSILRppltdgePLDKTEWQQIFDIMWSDPQA
..|  |||  |.. .|  .. |. |  ..|. .||| ... .|.| .|||.|.      .||.|.    .. |       | |. | .   |..|.||. 
ainrvyGfyeeckrry..kslrlyaefqdvfnalpltaliggrilcmhGGlskk.....lksldq..lrelkr.......pfdskeeslaidllwadpen

TMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQ
..    .  ||..| || ||  ..|..  .  |.|.|    .|.||. ..|..||||| .|     |  | ......|.  |. 
avkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfev
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 210-492 2.6e-56 183.6 In-house 15-278 (287) alignment 
Range on Protein: 210-492
Range on HMM: 15-278/287.0
VALILREAAKSLKQLPNIspvsTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSV
.  .|... . |. || .      | . .|..||.||.||||| .... | ..  . |.| ||.|||| . ||| |||.|| .|.|. | | |||||   
ilevlekieeileplpal....leveapitivGdihGqlddllrifnavGaapkvq.ylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

MNARYGFIREVESKYPrnhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGkyvsilrppltdGEPLDKTEwQQIFDIMWSDPQA
.|  |||  |.. |.    .|.    ..|.  ||| . .. |.| .||| |.   ||| .|.. .               ||.  |   . |..|.||. 
inklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkp............ttplacde.glqvdllwadpek

T-MGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQ
   .  .| .|.  | ||  . |..|..  .. ..|.|| . .|..|. |....|.|||. | .  .| || . ... |   ||.
daktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvv
subfamily_PPP4C_pd Subfamily PPP4C 210-494 2.7e-51 167.5 In-house 21-283 (288) alignment 
Range on Protein: 210-494
Range on HMM: 21-283/288.0
VALILREAAKSLKQLPNISpvstAVSQQVTVCGDLHGKLDDLLVVLHKNGLPsSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSV
|  . ..| . | .  |.      |   ||||||.||.. ||| ... .|    .. |.| |||||||.  .| .||||.| . .|. . | |||||   
vkalcakareilveesnvq....rvdspvtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

MNARYGFIREVESKYPRnhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGKYVsilrpPlTDGepldktewqQIFDIMWSDPQA
.   |||  |. .||     ..  .  ||. .|.|..... ....||||.| | ..|| |.|||| . |     |  .|         .. |..||||. 
itqvygfydeclrkygs..anvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqev.....p.heg.........plcdllwsdped

TMGCvPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYI
. |    . ||||  || ||...| ..  .. ..|.|.   .|. .. ..|..|..|| ||     |. | ..|...|  .|  . 
aegw.avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 210-486 2.7e-48 157.4 In-house 21-279 (290) alignment 
Range on Protein: 210-486
Range on HMM: 21-279/290.0
VALILREAAKSLKQLPNIspvsTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSV
.  ||... . |. || .      | . ... ||.||.||.||  ... | |   . ..| ||.|||| . ||| |||. . . ... | | |||||   
ileilekieeileplpal....leveapivivgdihgqldallryfdavgyppkvk.flflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

MNARYGFIREVESKypRNhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDStsldlIKSIDRgkyVSILRPPLTDGeplDkTEWQQIFDIMWSDPQA-
.|  |||  |.  |  |.  |.    ..|.  |.| . .. ..| .||| |.      |.| .    .  |. | ...   .  .   . |..|.||.  
vnrlygfkeelark..rg.srlwkqyqdvfaelslcarvgrkilcmhggisqk.....ieswes...lkalkkprvpl...t.cdeglqvdllwadptrd

-TMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQL
 .     |  |.  | || .. |..|..  || ..|.|| | .|..|. |.|..|.|||  |    .| || ... . |
kddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvsesl
PPP_3 213-493 4.1e-94 307.6 In-house 6-269 (271) alignment 
Range on Protein: 213-493
Range on HMM: 6-269/271.0
ILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLlVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNA
 |.|  |.||.... ..... .|..||||||.||.|||| . |.|||.||... |.|.||.||||| .||||||||.| . .|. |.|.|||||.. .|.
elkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqink

RYGFIREVEskYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDST-SLDLIKSIDRgKYVSILRPPLTDGEpldktewqqifdimWSDPQATMG
.||| .||   . ...|...  . ||...|||.......||.||||.|.|. ||| ||...| | ..  . .|.| .              .|.......
vYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikkler.kievpeegklldll..............lssdpekee

CVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQY
.. |. ||||..||||||..||....|...||.||.|..|.|..||.|..|.|||.||.  .||.||...|...|...|.|.
glenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
PPP_1 214-481 4.3e-87 284.7 In-house 6-263 (264) alignment 
Range on Protein: 214-481
Range on HMM: 6-263/264.0
LREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLlVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNAR
|.|  |.||.|.|...... ||...|||||.||..||| . | |.|.||... |.|.||.|||||  .|.|||||.| | .|. .||.|||||.. .. .
laelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv

YGFIREVEskYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLDktewqqiFDIMWSDPQATMGCV
|||  ||   . .  |.|.  . .|. .|||..... ..|||||| |....| . . . | | ..  . .|.|    |        ||..||.... ..|
ygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd.......vdillsddkeqeeav

PNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIR
.|. ||||  ||.|||..|||.. |...||.||.|..|.||....|..|||||||||  |||.|||..
ansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPG1_pd Subfamily PPG1 220-497 5.6e-43 140.3 In-house 25-297 (300) alignment 
Range on Protein: 220-497
Range on HMM: 25-297/300.0
SLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGlPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIRE
 ||.|         .   ||| ||.||.. |.| ...  | .     |.| ||.||||   .| . ||. | | .|  . | |||||   .   |||  |
klkellvkesnvieirspvtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyte

VESKYPRNhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGKYVSIlRPPLTDGEPLDKTEWQqifDIMWSDPQATMGCVPNTLR
.  ||  |  |.  .. |.. .| | ....  .  ||||.| |  |.| || .|| . |      |.|    |  | .   .     |.       .. |
clrkyggn.srvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpn.egaladllwsdpeenn...nptldhpdregqhfvvsqr

GAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAA
|||  .| ||. .||.   .  .||.|.   .|.. . |||. |..|| ||     || . . |....  .|  | .| 
gagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 226-492 9.2e-48 156.1 In-house 20-270 (284) alignment 
Range on Protein: 226-492
Range on HMM: 20-270/284.0
NISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYp
|  |.   |   . .|||.||.. ||| .. |||.|  .| |.| ||.|||||. || .|||..  . ||| .|. ||||| |..|  |||  |.. .| 
nkqpmlievnspinicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrry.

rNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDstsldLIKSIDRgkYVSILRpPLTDGEPldKTewqQIFDIMWSDPQAT-MGCVPNTlRGAGVWF
 |.  .   .. |.  .|| ...  |.| .||| |      ... . .    .| | |. . ||  .|      ||.||||     |  ||. ||    |
.nkpsvyvsfegvfsvmpltalvgqrilcmhggvsk.....mlqnvsq..lraikr.pfdnpep..nt...laidilwsdptnfqkgwnpns.rgvsyvf

GPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQ
| |   ..|.| ..  |.|.|.   .|.||. . ...|||||  |     |  | . .|..|.  || 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvv
subfamily_PPZ_pd Subfamily PPZ 228-490 1.3e-40 132.8 In-house 44-288 (300) alignment 
Range on Protein: 228-490
Range on HMM: 44-288/300.0
SPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVesKYPRN
 |    .| .| . ||.||.  ||| .. | |.| |.| |.| ||.|||||. || .||||   . .|. .|| ||||| . .   |||  |.  |   |
qpallelspsvkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydec..krrcn

HKRILAFIDeVYRWLPLGSVLNSRVLIVHGGFSDstsldLIKSIDRGKYVSilRppltdgePLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPD
 |   .|.|  .  ||| ...  ... ||||.|      ...|.|  ..|.  |       | |  ..  | |..||||  .     .  ||    .   
ikiwktfvd.tfntlplaaivagkifcvhgglsp.....vlnsmdeirhvv..r.......ptdvpdfglindllwsdptdssnewednergvsycynkv

VTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHF
  ..||..  .  | |.|    .|.||. |  ..|.||| ||     | || . ... |.  |
ainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsf
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 229-490 7.7e-50 162.9 In-house 28-277 (284) alignment 
Range on Protein: 229-490
Range on HMM: 28-277/284.0
PVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLP-----SSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESK
..   .   |...||.||. .|||..|. || |     . .. |.| ||.||||   .||..||... | .|. ||| |||||   .| .|||  | . .
klkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkr

YPrnhKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDStSLDLiKSIDRgkyvsILRppltdgePLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVW
|    ...   ..  .  .|| .|...... .||| |.   ||| | .|.     . |       |.| ..   | |. |.||.|..    .. ||||  
ys...ealyeafqlafnamplcavvskkiicmhggised.lldl.kqldk.....ler.......pidipdigviadltwadpeaevegykesprgagkv

FGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHF
||..  ..||....|  |.|.|.   .|.||. |.|..|||||  |     | .| ......|.  |
fgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasf
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 229-264 1.4e-06 20.8 In-house 29-64 (317) alignment 
Range on Protein: 229-264
Range on HMM: 29-64/317.0
PVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSS
|.   .   ||..||.||. .|||..|. || | ||
plkleleapvtivGdihGqfedllalldlnGwplss
subfamily_PPP6C_pd Subfamily PPP6C 232-489 8.4e-48 156.0 In-house 38-277 (290) alignment 
Range on Protein: 232-489
Range on HMM: 38-277/290.0
TAVSQQVTVCGDLHGKLDDLLVVLHKNGLpSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNhkRI
 .||  ||||||.||.. ||. .... |     . ||| |||||||   || . .||.| . .|. . | |||||   .   |||  |  .|| .     
qpvsspvtvcgdihgqfydleelfrtggq.vpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygna..na

LAFIDEVYRWLPLGSVLNSRVLIVHGGFS-DSTSLDLIKSIDRGKYVSilrpplTDGepldktewqQIFDIMWSDPQATMgCVPNTLRGAGVWFGPDVTD
  .. .|.  |....... .|| ||||.| | . || |. |.| . ..       .|          . |..||||.        . ||||  ||  ||.
wkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeip......hkg.........afcdlvwsdpedve.twavsprgagylfgskvtk

NFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPH
.|..   |. ..|.|.   .| ..| |.|..|..|| ||     |  . ..|...   .
efvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeere
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 232-496 5.2e-47 153.5 In-house 47-294 (299) alignment 
Range on Protein: 232-496
Range on HMM: 47-294/299.0
TAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYprNHKRI
  |   . ||||.||.  ||| ...|.|.|  .| ..| ||.||||.. ||.. |||   . .|.  |. |||||   .|  |||  |.. .|  .  |.
leveapiivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkry..kstrl

LAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRgkyvsilrppltdgePLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTD
 . ... . ..||  ...||.| .|||.|   ..|| .. . |               | |  .     |..|.||. ..    .  ||    ||.||  
wsifqdafaampltgligsrilcmhgglspklqtldqlrdltr...............pqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvva

NFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISA
. ..|  .  | |.|.   .|.||. ..|..|||||  |     |  | ......|.  || .  .
dvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 232-484 1.2e-42 139.2 In-house 29-288 (302) alignment 
Range on Protein: 232-484
Range on HMM: 29-288/302.0
TAVSQQVTVCGDLHGKLDDLLVVLH----------KNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVE
. .|  ||. ||.||. .||. .|           |     ||. .|| ||.||||.. .| . |...| . .|.   | |||||   .|  |||  |.|
aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreele

SKYPRNH-KRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGkYVSILRPPLTDGE-PLDKTEWQQIfDIMWSDPQatmgCVPNTLR
 .. ... |.|    .||. ..|| ... ...| |||| |.  .||. ||.|.|     .   .|..     | .. |..  .. . |.     . |..|
nrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrp.lkevtedslaqdllfadpldvqll.aavsekPk....yaknivr

GAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNN
|  | |      .. .|  |. ..|.|   |.|. |. |.|..|||||..|     |||| .... 
glsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 232-484 1.4e-42 139.0 In-house 30-289 (302) alignment 
Range on Protein: 232-484
Range on HMM: 30-289/302.0
TAVSQQVTVCGDLHGKLDDLLVVLH----------KNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVE
. .|  ||. ||.||. .||. .|           |     ||. .|| ||.||||.. .| . |...| . .|.   | |||||   .|  |||  |.|
aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreele

SKYPRNH-KRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRGkYVSILRPPLTDGE-PLDKTEWQQIfDIMWSDPQatmgCVPNTLR
... ... |.|    .||. ..|| ... ...| |||| |.  .||. ||.|.|     .   .|..     | .. |..  .. . |.     . |..|
nrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrp.lkevtedslaqdllfadpldvqll.aavsekPk....yaknivr

GAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNN
|  | |      .. .|  |. ..|.|   |.|. |. |.|..|||||..|     |||| .... 
glsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 233-487 5.3e-48 156.6 In-house 30-266 (280) alignment 
Range on Protein: 233-487
Range on HMM: 30-266/280.0
AVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYprnHKRIL
 |   |.|||||||.  ||| .. . ..|  .| |.| ||.||||.  |||.||||.  . .||  .. |||||   .| .|||  ||  .|   .. . 
evdapvavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrry...slaly

AFIDEVYRWLPLGSVLNSRVLIVHGGFSDStsldlIKSIDRgkYVSILRPPLTDGEPLDKtewqqifDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNF
. ..|..  ||| .... |.| .|||.|.      ..|.|      . ||  .. | |..       |..|.||.  .    .. ||. | || .|  ..
nefqelldslplvalvsgrilcmhgglsqk.....lvsldd..laelrrpfdsedeclam.......dllwadpenkvtgwaensrgvsvifganvvkdl

LQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLM
 ..  .  ..| |.   .|.||. |.|..|.||| .|    .|. | ......|.
tekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderli
subfamily_YNL217W_pd Subfamily YNL217W 233-361 5.9e-08 25.5 In-house 7-138 (235) alignment 
Range on Protein: 233-361
Range on HMM: 7-138/235.0
AVSQQVTVCGDLHGKLDDLLVVLH-KNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLlslylaFPNAVFLNRGNHEDSVMNArYGFIREVESKYPRNHKRI
  .... | || ||  |.|. .|. |.|        |. ||....| . .||. ..        . |   .||||  |. | | .... .   |..    
vlgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla.ykwvkkpkgaeplefssk

LAFI-----DEVYRW---LPLG-SVLNSRVLIVHGGFSD
. |.     .. ...   |.   ..    .|.||.| . 
fsflesklskadmeyarelgfsldipsdellvvhaGlvp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 234-488 1.6e-46 151.9 In-house 48-287 (297) alignment 
Range on Protein: 234-488
Range on HMM: 48-287/297.0
VSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNpYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYprNHKRILA
|   . ||||.||.. ||| ..|. | | ..| |.| ||.||||.  .| ..|||.  . ||  .|| |||||  ..|  |||  |.. .|  .  |. |
vnapikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkry..qsvrmya

FIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIksidRGKYVSILRPplTDGepldkTEwQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFL
 ...|. ||||  .. ...| .|||.|   . ..        .  | |.  |.|      | . . |..|.|| . .  . .  ||||. || |   .  
afqdvfnwlpltgliatkilcmhgglsplltkeft....ldtlrkiers..teg.....ke.rlvadllwadpisglsgfmenqrgagcgfgrdavlklc

QRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMP
   .|  | |.|.   .|.||.   |..|||||  |     |  |..  ...|  
sefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqc
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 235-497 1.1e-41 135.9 In-house 34-278 (281) alignment 
Range on Protein: 235-497
Range on HMM: 34-278/281.0
SQQVTVCGDLHGKLDDLLVVLHKNGLPSSsNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPrnhKRILAF
 . ..| ||||.. .||  ...  | ..  . .|| ||.||||...||||.||..| ..... ..| ||||| . .| .|||  |   ||    . . | 
dkPivvvGdlhaqfndlkrlfellgrvpe.evlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtkyG...eelwal

IDEVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRgkyvsilrppltdgePLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFL
... .  ||. .  . |||..|||.|   |.|| .. . .               |... .   . |..|.||.       .. ||..  || .| |.  
fqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpk...............pirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvc

QRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAA
.|  . ..||.|    .| | .   |.||.||. || |   | .| ......|  ..|... |.
krleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_PPPLV_pd Subfamily PPPLV 235-487 1.5e-36 119.2 In-house 23-280 (290) alignment 
Range on Protein: 235-487
Range on HMM: 23-280/290.0
SQQVTVCGDLHGKLDDLLV---VLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRI
   . | |||||   || .   || . |   .   ..| ||.||||. ..|..  ||.| . .|  |.| |||||   .   . .  |   |.  . . .
ksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleev

LAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGkYVSILRppltdgEPLDKTEwqQIFDIMWSDPQA------------TMGCVPNTLRG
   . .|. .||| .|.. .|. ||.|   ..  .   |  .   .  |.      ...| .     .||.||||.               | |.|  ||
weafnnvfdalplaavidrkvfcvhagipraimtqayisaiqd.ilerlk......ddidgap..laldilwsdpaedrdlslrgelvlneGfvdndrrG

AGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYyAIGSNKGAYIRLNNQLM
 |  |. |  ..||.|  ||.|.|.|| | .| .. .. ...|.||.|.|   .||. | | .... .
tghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssry.cGssneaalilvdkkkl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 237-493 1e-40 133.1 In-house 8-253 (263) alignment 
Range on Protein: 237-493
Range on HMM: 8-253/263.0
QVTVCGDLHGKLDDLLVVLHKNGLPSsSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNH--KRILAF
 . .||| ||. .||| ..   |  .    |.| ||.|||| . |||..||.|| ||.|  ..| |||||   .|  |||  |.. .. |.   . .  .
pinicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

IDEVYRWLPLGSVLNSRVLIVHGGFSDStsldlIKSIDRGKYVSIlrpPLTDgeplDKTEwQQIFDIMWSDPQA-TMGCVPNTLRGAGVWFGPDVTDNFL
...|. ..|| .... |.| .||| |       .||.|  . . .   ||       ||      |..|.||.  . |  || .|     ||    |.. 
fnqvfsymplcaivskrilcmhggisph.....lkslddiraipl...plet....akth.placdllwadpekdakgfepnkiraisnvfgkkevddlc

QRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQY
.|  .  ..|.|.    |. |. | ..||.|||| |     |  | . .|. |   ||| 
krldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvql
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 237-500 6.1e-36 117.1 In-house 48-296 (307) alignment 
Range on Protein: 237-500
Range on HMM: 48-296/307.0
QVTVCGDLHGKLDDLLVVLHKNGLPSSSnPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRILAFID
 . | |||||...||. ..   | |  .  ||| ||.||||   ||..|||..  ...|. . | ||||| . .| .|||  |. .  |.  . | |...
pcvvvgdlhgqfndlinmfillgrppet.vyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfq

EVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSidrgkYVSILRPPLTDgepldktewqQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQR
 ..  ||. ... ...| .|||.| . | || ..      .   .| |.             . |..|.||. ..     . ||.|. || .| |.  .|
rcfnnlpisaliatkilcmhgglspaltcldelrn.....hpkpirnpfrg..........ivndmlwadpdpsvfewkassrgsgftfgtnviddvckr

HRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQT
  .  .||.|.   .|.  .   |.||||||  |  .  | |. ..... |  . | .. .. . 
lgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpeseni
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 237-495 9.8e-35 113.3 In-house 34-274 (280) alignment 
Range on Protein: 237-495
Range on HMM: 34-274/280.0
QVTVCGDLHGKLDDLLVVLHKNGLPsSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNhkrILAFID
 . | ||.| . .|.  ..   |     .  .| ||.|||| .|.|||.||. | . . . ..| |||||   .|  |||  |.. ||      .   ..
pikvigdihaqyqdmnrlfdligrv.peeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvg...lwwdfq

EVYRWLPLGSVLNSRVLIVHGGFSDS-TSLDLIKSIDRgkyvsilrPpltdGEPLDKTewqQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQR
 ..  .|.  ... |||..|||.|     || |. | |        |     ||||.     . |..||||         ..||    ||  | ..  . 
scfnrmpmsgliskrvlcmhgglspelinldtirnipr........p....cepldrg...llidllwsdptnkgegwfhsirgisymfgkgvveqacks

HRLSYVIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYIS
  .  .||.|.   .|.|.|   ..||.||  || |  .|  | . || .|   | | | 
leidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
PPP_2 238-448 7.2e-69 224.4 In-house 1-198 (198) alignment 
Range on Protein: 238-448
Range on HMM: 1-198/198.0
VTVCGDLHGKLDDLlVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVEskYPRNHKRILAFIDE
|||||||||.|||| . |.||||||... |.|.||.|||||..||||||||.| | .|. |.|.|||||.. .|..||| .||   . ...|...  . |
vtvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqe

VYRWLPLGSVLNSRVLIVHGGFSDSTS-LDLIKSIDRgKYVSILRPPLTDGEPLDKtewqqifdimWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRH
|...|||.......||.||||.|.... || ||...| | .|  . .|.| .. .|          .|||....... |. ||||..||||||...|...
vfelLplaalidekvlvvHGGlseeiklldqikkeer.kiespeegklldlleeek..........lsdpkekeellansarGagllfgpdvteellekn

RLSYVIRSHECK
.|...||.||.|
klkliiRaHevk
PPP_5_Dcr2 238-448 2.1e-68 223.3 In-house 1-199 (199) alignment 
Range on Protein: 238-448
Range on HMM: 1-199/199.0
VTVCGDLHGKLDDLLVVLHKNG-LPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYprNHKRILAFID
|||||||||.|||||. | |.| .||... |||.||.|||||..||||||||.| | .|. |.|.||||||. .|..|||  || |||  ..|.|.  . 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykils

EVYRWLPLGSVLNSRVLIVHGGFSDSTS-LDLIKSIDRgKYVSilrpPLTDGEPLDKTewqqifdiMWSDPQ-ATMGCVPNTLRGAGVWFGPDVTDNFLQ
.|..|||| ......||.|||| |...  ..|.. |.| |...    | ..||  |..        .||||. |. ||  |. ||||..||||||..||.
dvfdwlPlaalidekvlvvhgglspeiksiellekier.kiei....peekgekadll........lwsdprdaqegcklnseRGagllfgpdvtekfle

RHRLSYVIRSHECK
...|...|||||.|
knnlkliirshelk
PPP_4 238-448 7.9e-67 218.1 In-house 1-197 (197) alignment 
Range on Protein: 238-448
Range on HMM: 1-197/197.0
VTVCGDLHGKLDDLLVVLHKNG-LPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKyprNHKRILAFID
|||.||.||.|||||. | ||| |||... |||.||.|||||..||||||||.| | .|. |.|.|||||.. .|..||| .|| .|   ..|.||  . 
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklq

EVYRWLPLGSVLNSRVLIVHGGFSDSTS-LDLIKSIDRgKYVSilrppltdgepldKTEWQQIFDI-MWSDPQ-ATMGcVPNTLRGAGVWFGPDVTDNFL
.|...||| ......||.|||| ||... || |. |.| |..|             ..| ... |. .||||. |. | . |. ||||..||||||..||
dvfdllplaalidekvlvvhgglsdelesldkierier.kies.............pleeekrkdlllwsdpreaqeg.lansvrGagllFgpdvtekfl

QRHRLSYVIRSHECK
....|...|||||.|
eknnlkliirshelk
Metallophos Calcineurin-like phosphoesterase 238-449 1.2e-40 133.0 Pfam-A 3-200 (200) alignment 
Range on Protein: 238-449
Range on HMM: 3-200/200.0
VTVCGDLHGKLDDL---LVVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLL--LSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVES----------
..|.|||||.||||   |  |.|.. ..  ....|.||.||||....|.| ||  |.| |..|. |||.|||||.. .| .|||  |. .          
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

---------------------KYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKsidrgkyvsilrppltdgepldktewqqifdi
                     .||.. ... ... |.. .||| .  . ..|..||..|.|. . .                                  
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

mwsdpqatmgcvpntlrgAGVWFGPDVTDNFLQRHRLSYVIRSHECKP
                  ....||||.....|..... .|.|.|..||
..................gselfgpdalekllekygvdlvlrGHtHkp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 266-488 4.2e-44 144.0 In-house 102-307 (317) alignment 
Range on Protein: 266-488
Range on HMM: 102-307/317.0
PYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYprnHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDS-TS
 |.| ||.||||   .||..||..| |..|. ||| |||||   .| .||| |||. .|    ...      ..  ||| .|.|...| .||| |.. ..
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry...saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDLIKSIDRgkyvsilrppltdgePLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIF
|. .. ..|               ||| ..   . |. |.||.|..    .. ||||  ||..  ..||....|  |.|.|.   .|.||. | |..|||
lkqldklkr...............pldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtif

SASNYYAIGSNKGAYIRLNNQLMP
|| .|     | .| ......|. 
sapsycGqldniaavlsvdkklki
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 267-486 6.6e-36 117.1 In-house 122-324 (339) alignment 
Range on Protein: 267-486
Range on HMM: 122-324/339.0
YVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRnhkRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDStsld
|.| ||.||||   .||..|| .| ||.|. ..| |||||   .|. ||| |||. .|     ..   .....  .|. .|.|  .. .||| |.     
ylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda...qlyecfqnmfnvfpfcavinntimcmhggiseh....

lIKSIDRgkyVSILRPpltdgePLDKTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSA
 . |...   .|...       ||.  .   . |. |.||. |      . ||| . |||     ||..  |  ||| |.   .|.||.   ...|||||
.ltsfnq...fsvfkr......pleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsa

SNYYAIGSNKGAYIRLNNQL
 ||     |  | . ....|
pnycgqndntaavfsidkkl
EF-hand_5 EF hand 616-638 2e-07 19.5 Pfam-A 1-23 (25) alignment 
Range on Protein: 616-638
Range on HMM: 1-23/25.0
LVAIFNIIDADNSGEITLDEFET
|...|. .|....| |. .|...
lkdtFrafDkNgDGkIsreELkr
EF-hand_6 EF-hand domain 617-640 1.9e-07 20.5 Pfam-A 3-26 (31) alignment 
Range on Protein: 617-640
Range on HMM: 3-26/31.0
VAIFNIIDADNSGEITLDEFETAI
 ..|...| |..|.|...|.  |.
reaFklfDkdgdGkidaeELrkaL
EF-hand_7 EF-hand domain pair 618-680 2.6e-12 36.6 Pfam-A 4-66 (66) alignment 
Range on Protein: 618-680
Range on HMM: 4-66/66.0
AIFNIIDADNSGEITLDEFETAIDLLVAHMPgaysKAEMLEK----CRMMDLNGDGKVDLNEFLEAF
 .|. .| |..| .. .|.. ... |  ..       |. |      ...|.||||.....|||.|.
eaFkllDkdgdgyldkeeLlrllkhlgspli....deevrevldyifkeiDkngdGvlsfeEflqai
EF-hand_1 EF hand 618-640 9.1e-08 20.9 Pfam-A 4-26 (29) alignment 
Range on Protein: 618-640
Range on HMM: 4-26/29.0
AIFNIIDADNSGEITLDEFETAI
 .|...| |..| |...|| .|.
eaFkefDkDgdGkIsfeEfkeal
EF-hand_8 EF-hand domain pair 628-680 1.9e-09 26.3 Pfam-A 2-51 (54) alignment 
Range on Protein: 628-680
Range on HMM: 2-51/54.0
SGEITLDEFETAIDLLVAHMpgaYSKAEMLEKCRMMDLNGDGKVDLNEFLEAF
.|.|| .|.  |..||  ..    |. |. .  |..|..||||....||....
kGlItreeLkralallglkg...lseeevdilfrefDtdgdGkisfeEFcvll
EF-hand_6 EF-hand domain 656-681 4.1e-06 16.3 Pfam-A 2-27 (31) alignment 
Range on Protein: 656-681
Range on HMM: 2-27/31.0
MLEKCRMMDLNGDGKVDLNEFLEAFR
. |  ...| .||||.|..|.. |.|
lreaFklfDkdgdGkidaeELrkaLr
EF-hand_1 EF hand 660-681 6.7e-08 21.3 Pfam-A 6-27 (29) alignment 
Range on Protein: 660-681
Range on HMM: 6-27/29.0
CRMMDLNGDGKVDLNEFLEAFR
 ...| .||||....||.||..
FkefDkDgdGkIsfeEfkealk
EF-hand_5 EF hand 661-677 1.1e-06 17.1 Pfam-A 6-22 (25) alignment 
Range on Protein: 661-677
Range on HMM: 6-22/25.0
RMMDLNGDGKVDLNEFL
|..|.|||||..  |. 
rafDkNgDGkIsreELk