Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
Herpes_UL20 | Herpesvirus egress protein UL20 | 14-53 | 5.7e-06 | 12.6 | Pfam-A | 55-94 (179) | alignment | ||
Range on Protein: 14-53
Range on HMM: 55-94/179.0
VAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSR
..... | .| || ..... | .. | ||||.. .
rflvlglaitalyylrlalealllyrNikrDrLPLsklqq
|
|||||||||
CPDc_SM00577 | 60-212 | 3.3e-48 | 155.4 | In-house | 1-146 (146) | alignment | |||
Range on Protein: 60-212
Range on HMM: 1-146/146.0
KRKILVLDLDETLIHShHDGVLRPTVRPGTPPDFILKvvidkhpVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQ
|.|.|||||||||.|| .. .... . .|.|.... . ..|.|||.|| ||. .....|||.||.... | ....| ||..| . .|..|||
kkkvLVlDLdetLvhs.anmaepksfsevsptdslae.......tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkrllkyrvlyRq
HCTLELGSYIKD-LSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDT
.|.|. |...|| ||... |||..||.|||. ... .|.||..||...|..|||
dcrlvkgkllkddlsllkvdlskvviiDnseestlvnpenalkikpyisalsdt
|
|||||||||
subfamily_DULLARD_pd | Subfamily DULLARD | 61-212 | 1.3e-81 | 263.8 | In-house | 1-152 (153) | alignment | ||
Range on Protein: 61-212
Range on HMM: 1-152/153.0
RKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQH
||.||||||||||||.||.| ..||.|||.|||..||.|||.||.|.|.||||||.||.|||.||.||.||||||.|..||.||||..|.||||||||||
rktlvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryyrqh
CTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDT
|.|| |.|.||||.|.|||||..|||||| |||..||||||||||.||||||
CvlesgkytkdlslvssdlssviilDnspvayrknpdnaipikswlsdpsdt
|
|||||||||
NIF | NLI interacting factor-like phosphatase | 62-231 | 1.1e-53 | 173.4 | Pfam-A | 1-159 (159) | alignment | ||
Range on Protein: 62-231
Range on HMM: 1-159/159.0
KILVLDLDETLIHSHHDGVLrptvrpgtP-----PdfilkvviDkHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRY
|.|||||||||.|| .. | . . . . ...|.|||..| ||. .|..||.|.||||.. | .| |||| .. ..|.|.
ktLVLDLDetLvhskekkdl........kedgkkv........e.ektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklfkkrl
YRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSD-PSDTALLNLLPMLDALRFTADVR
||..|||. |.|.||||....|||..||.|.|| .....|||.|||.....| ..||.||.|||.|.||.. |||
yresctlrngkyvKdLsllgrdlsrvvivDdsprsfelqpdngipiepfygdsdkdtellkllpflealeksddvr
|
|||||||||
subfamily_SCP_pd | Subfamily SCP | 62-212 | 4.8e-47 | 151.3 | In-house | 1-142 (142) | alignment | ||
Range on Protein: 62-212
Range on HMM: 1-142/142.0
KILVLDLDETLIHSHHdgvlrptvRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRsILKRRYYRQHC
|.||.||||||.|| .| . .||.. | ||. . .| |||||| ||. |.. .|.|.||||. |.. ||| ||... .|. | .|..|
kclvidldetlvhssf........kpvknadfvvpveidgtvhqvyvlkrphvdeflkrvgelfevvlftaslakyadpvadlldkkk.vlrarlfresc
TLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDT
. |.|.|||| . ||....|.|||| .| ||.||.|..|||.|..||
vfhkgnyvkdlsrlgrdlkkviivdnspasyifhpenavpveswfddkedt
|
|||||||||
subfamily_FCP1_pd | Subfamily FCP1 | 63-204 | 2.7e-19 | 61.7 | In-house | 3-141 (146) | alignment | ||
Range on Protein: 63-204
Range on HMM: 3-141/146.0
ILVLDLDETLIHSHHDGVLrpTVRPgTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCT
.||.|||.||||. .| . .|. . | | . ... ..|..||.. ||| .|. ||| ..| . | ...| || .... ..| . .
vLvvDlDqtlihttkdpti..evke.ekkkdikkftlpeekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrdel
LELGSYIKDLSVV-HSDLSSIVILDNSPGAYrSHPDNAIPIKS
|. | .|.|. . .| | .||.|. . .. .| | .|.
ldassktkklkklfptddsmvviiDDredvW.nfaenlikvkp
|
|||||||||
subfamily_CTDSPL2_pd | Subfamily CTDSPL2 | 64-211 | 3.8e-39 | 125.9 | In-house | 2-141 (142) | alignment | ||
Range on Protein: 64-211
Range on HMM: 2-141/142.0
LVLDLDETLIHSHhdgvlrptVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTL
|||||||||.|. ... . . ..|. ... . .|..||.. ||| ||. .|...|||| ..| . | || .. .| | .|.||
lvldldetlvhcs........lekleeatltfpvlfenktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklikhrlfrehcvc
ELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSD
|.||||||.. ||. ..|.|||| |. .| |||.|||.| |
vdgnyikdlsilGrdlektiivdnspqafayqlenGipieswfedend
|
|||||||||
subfamily_TIM50_pd | Subfamily TIM50 | 108-211 | 8e-25 | 79.4 | In-house | 23-125 (126) | alignment | ||
Range on Protein: 108-211
Range on HMM: 23-125/126.0
VHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNsRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFS
..||| ||.||| ... .|.||||.. .. . . |||| ..... | .|..... |. .|||| . ||| ....| . ... .|.||. .| |
fkkrPgvdafleqlaelfeivvftseqgltaaplidkldP.kqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkksvklqpenalalkkweG
DPSD
. |
nadd
|