Gene FCP1 in Homo sapiens

Synonym: CCFDN, FCP1, CTDP1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family FCP
Subfamily FCP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP120_AA protein Get Run
HsapP120_AA_180-324 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CPDc_SM00577 181-324 4.4e-38 122.5 In-house 1-143 (146) alignment 
Range on Protein: 181-324
Range on HMM: 1-143/146.0
RKLVLMVDLDQTLIHT----TEQHCQQMSNKGIFHFqlgrgePMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKkLFSHRILSRDE
.|.||..|||.||.|.    ........|..   .         ... .||....||.|.|||.||..|| .|. ||.||. .|||.. |...|.|.|..
kkkvLVlDLdetLvhsanmaepksfsevsptdslae......tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkr.llkyrvlyRqd

CIDPFSKTG-NLRNLFPCGDSMVCIIDDREDVWKFAP-NLITVKKYVYFQ
|    .|   .. .|... .|.|.|||..|..... | |.. .|.|....
crlvkgkllkddlsllkvdlskvviiDnseestlvnpenalkikpyisal
subfamily_FCP1_pd Subfamily FCP1 182-324 5.3e-64 206.7 In-house 1-146 (146) alignment 
Range on Protein: 182-324
Range on HMM: 1-146/146.0
KLVLMVDLDQTLIHTTEQ---HCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECI
||||.|||||||||||..   .......|.| .|.| . . . ...|||..|.||||..||||||..|.|.| ||..|| .|||||||||.|||||||..
klvLvvDlDqtlihttkdptievkeekkkdikkftlpeekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrdell

DPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQ
|..|||..|..|||..||||.|||||||||.||.|||.||.|..|.
dassktkklkklfptddsmvviiDDredvWnfaenlikvkpykffk
NIF NLI interacting factor-like phosphatase 184-321 4.6e-25 80.4 Pfam-A 2-133 (159) alignment 
Range on Protein: 184-321
Range on HMM: 2-133/159.0
VLMVDLDQTLIHTTEQHCQqmsnK----GIfhfqlgRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFsHRILSRDECID
.| .|||.||.|..|.  .    |     .      . .   .. .||....||....| ||. .|| .|. ||. .   |||.|||| ...|.|..|  
tLVLDLDetLvhskekkdl....kedgkkv......eektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklf.kkrlyresctl

PFS-KTGNLRNLfpcGD--SMVCIIDDREDVWKF-APNLITVKKYV
  . .. .|. |   |.  | | |.||.......   |.| .....
rngkyvKdLsll...grdlsrvvivDdsprsfelqpdngipiepfy
subfamily_DULLARD_pd Subfamily DULLARD 184-321 1.4e-17 55.8 In-house 3-146 (153) alignment 
Range on Protein: 184-321
Range on HMM: 3-146/153.0
VLMVDLDQTLIHTTEQHCQQMSNK------GIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILsRDEC
.|..|||.||||..... .. ..|       . .... . . ...   |||.  ||....| |.| .|| . . ||.... .|| .. ....|   |..|
tlvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryy.rqhC

IDPFSKT-GNLRNLFPcGDSMVCIIDDREDVW-KFAPNLITVKKYV
.  ..|   .|  . .   | |.|.|.    . |.. | |..| ..
vlesgkytkdlslvss.dlssviilDnspvayrknpdnaipikswl
subfamily_SCP_pd Subfamily SCP 184-313 5.3e-12 37.7 In-house 2-127 (142) alignment 
Range on Protein: 184-313
Range on HMM: 2-127/142.0
VLMVDLDQTLIHTTEQHCQqmSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEkKLFSHRiLSRDECIdpFSK
.|..|||.||.|.. .  .  .   .   ..   .  ..   ||| ..||.....|.|. .||     ||. .| .|| . |....| | |..|.  | |
clvidldetlvhssfkpvk..nadfvvpveidgtvhqvyvlkrphvdeflkrvgelfevvlftaslakyadpvadlldkk.kvlrar.lfrescv..fhk

TGNLRNLFPCGDSM--VCIIDDREDVWKFAPN
.  ...|   | ..  | |.|.    . | |.
gnyvkdlsrlgrdlkkviivdnspasyifhpe
subfamily_CTDSPL2_pd Subfamily CTDSPL2 185-278 7e-19 60.2 In-house 2-92 (142) alignment 
Range on Protein: 185-278
Range on HMM: 2-92/142.0
LMVDLDQTLIHTTEQHCQQMSNKGIFHFQlgRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRiLSRDECI
|..|||.||.|.. .. .. . . . .|.    .  .. ||||. ..|||...||.|. .||   ..||. .  .|||||||. || | |..|.
lvldldetlvhcslekleeatltfpvlfe..nktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklikhr.lfrehcv
subfamily_TIM50_pd Subfamily TIM50 223-320 7.7e-07 21.3 In-house 23-119 (126) alignment 
Range on Protein: 223-320
Range on HMM: 23-119/126.0
TRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPeKKLFSHRILSRDECIDPFSKTGNLRNLFpCGDSMVCIIDDREDVWKFAP-NLITVKKY
.. ||  . |||..|.|.|. |||  . |.|. .   ||| |.| ..|..         ... .| .|     | | ..|  ..  |. | | ...||.
fkkrPgvdafleqlaelfeivvftseqgltaaplidkldP.kqlimyrlfrdatkyvdGehvkdlskln.rdlskvivvdldkksvklqpenalalkkw
PTCB-BRCT twin BRCT domain 638-710 1.3e-15 46.8 Pfam-A 2-63 (63) alignment 
Range on Protein: 638-710
Range on HMM: 2-63/63.0
AIIFSGLHPTNfpieKTREHYHATALGAKILTRLvLSpdapdRATHLIAARAGTEKVLQAQECGhLHVVNPDW
 | .||.....    ..|  ....||||.| ..|  .     . ||||..||..||. .||..| ..||.|.|
vicvsgysgdd....rkrlqkliralGasiskdl.tk.....kvTHLickraegeKyekAqkwg.ipvVspeW
BRCT BRCA1 C Terminus (BRCT) domain 661-715 1.7e-06 17.7 Pfam-A 29-78 (78) alignment 
Range on Protein: 661-715
Range on HMM: 29-78/78.0
TALGAKIltrlvlSPDAPDRATHLIAARA--GTEKVLQAQECGhLHVVNPDWLWSCL
 .||.|.      |..  .. |||.. .   .|.|.|.|.. .  ..||..||. |.
kelGGkv......stevskktthlvvgepelrtlkylaaialn.ipivneeWlldci
FCP1_C FCP1, C-terminal 716-961 3.5e-132 427.4 Pfam-A 1-263 (263) alignment 
Range on Protein: 716-961
Range on HMM: 1-263/263.0
ERWDKVEEQLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGP-PAP-----SSSLPIRQEPSSFRAVP
|||.|||||||||.||.||.|||||||||||||.| .||||||.|. .|||||||||||||.||||||.||... |||     ||||....||||.|||.
erwekveeqlfPlkddytkkqrensPaafpdresvlqtalfhpapirlkaqPgPevriydsvtGklirkgaqasapaplqapsssslsdkgepsslravq

PPQPQMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRP----EEQEEEPQPRK---PGTRRERTLGAP
|.|.|.||||....||.||||||||||||||||||||||||||||||||||||||||||||||||||...    ||.||..|.||   |..|||....||
phqeqlfgeeagesqddeqpGPsrrkrqpsmsetmPlytlckedlesmdkevddilGegsddsdsekkkkedkeeeeeeaaqqrkqkaPeerresdvrap

ASSERSAAGGRGPRGHKRKLNEE---DAASESSRESSNEDE-GSSSEADEMAKALEAELNDLM
.||||||||||.||||||||.||   ||.||.|.||||||| ||||||||||.|||||||||.
sssersaaggrvPrGhkrkldeedeedaeseeskessnedeeGssseademaaaleaelndll