Gene TIMM50 in Homo sapiens

Synonym: TIM50, TIM50L, PRO1512, TIMM50

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family FCP
Subfamily TIM50
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP124_AA protein Get Run
HsapP124_AA_250-376 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
NIF NLI interacting factor-like phosphatase 251-398 6.9e-35 112.3 Pfam-A 1-159 (159) alignment 
Range on Protein: 251-398
Range on HMM: 1-159/159.0
YTLVLELTGVLLHPEWSL-----------ATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDP-HGFISYRLFRDATRYMDGHHVKDIS
.||||.| ..|.| ...             | ...||||| . ....|.  ||.||||... ..| |..| .|| . ....||.|. ... .|..|||.|
ktLVLDLDetLvhskekkdlkedgkkveektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklfkkrlyresctlrngkyvKdLs

CLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGN-SDDRVLLDLSAFLKTIAlnGVEDVR
 |.||  |||.|| ....|.|||.||. ..|. |. ..|. ||.|. ||. ..   ..|||
llgrdlsrvvivDdsprsfelqpdngipiepfygdsdkdtellkllpfleale..ksddvr
CPDc_SM00577 251-376 4e-27 87.0 In-house 3-145 (146) alignment 
Range on Protein: 251-376
Range on HMM: 3-145/146.0
YTLVLELTGVLLHP----------EWSLA-----TGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYR-LFRDATRYMDGHHV
..|||.|  .|.|           |.|       | ....|||...  ....| |.|.|||||.. ..| ...| .||.. ..|| |.|...|...|...
kvLVlDLdetLvhsanmaepksfsevsptdslaetlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkrllkyrvlyRqdcrlvkgkll

KD-ISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDD
||  | |..|. .||..| ..|.....| | .. .|.  ...|
kddlsllkvdlskvviiDnseestlvnpenalkikpyisalsd
subfamily_TIM50_pd Subfamily TIM50 252-377 1.9e-61 197.8 In-house 1-126 (126) alignment 
Range on Protein: 252-377
Range on HMM: 1-126/126.0
TLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVD
||||||. ||.||||. .||||||||||......|||.|.|||.||||.|.||.||||..||...|.||||||||.|.||.||||.|.|||| ..|.|||
tlvlelkdvlvhpewtyktGwrfkkrPgvdafleqlaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvd

CKKEAFRLQPYNGVALRPWDGNSDDR
..|....||| | .||..|.||.||.
ldkksvklqpenalalkkweGnaddk
subfamily_FCP1_pd Subfamily FCP1 272-360 7.1e-06 18.2 In-house 43-133 (146) alignment 
Range on Protein: 272-360
Range on HMM: 43-133/146.0
WRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFI-SYRLF-RDaTRYMDGHHVKD-ISCLNRDPARVVVVDCKKEAFRLQ
.  |.||...  ...|..|||. |.| .| . |  .   .||.. . | |.. ||       ...|.  . ...|   ||..| ... .. .
yyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrd.elldassktkklkklfptddsmvviiDDredvWnfa
subfamily_DULLARD_pd Subfamily DULLARD 273-375 9e-16 49.9 In-house 47-150 (153) alignment 
Range on Protein: 273-375
Range on HMM: 47-150/153.0
RFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPH-GFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD
.  ||| .. .... .  |..||||. . . | ...| .| . | .. |..|.  .  .|...||.|... |  .|...|   .|.| .| |..... | 
yvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryyrqhCvlesgkytkdlslvssdlssviilDnspvayrknpdnaipikswl

GNSD
 ...
sdps
subfamily_CTDSPL2_pd Subfamily CTDSPL2 275-376 1.3e-22 72.3 In-house 39-141 (142) alignment 
Range on Protein: 275-376
Range on HMM: 39-141/142.0
KKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGF-ISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGN
..|| ......... |.|...||. . . |  |.| .||.   | .||||.   ..|| ..||.|.| || .....|| . .|| .|  ||. .  |  .
rlrpflreflervsklfevilftaskkvyadklldlldpekklikhrlfrehcvcvdgnyikdlsilGrdlektiivdnspqafayqlenGipieswfed

SDD
..|
end
subfamily_SCP_pd Subfamily SCP 275-376 1.4e-19 62.3 In-house 40-141 (142) alignment 
Range on Protein: 275-376
Range on HMM: 40-141/142.0
KKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNS
 ||| .. ...... |.|.|.||.     | |. | .| ......||||..  .  | .|||.| | ||  .|..||   ... . | | | .. |  ..
lkrphvdeflkrvgelfevvlftaslakyadpvadlldkkkvlrarlfrescvfhkgnyvkdlsrlgrdlkkviivdnspasyifhpenavpveswfddk

DD
.|
ed