Gene PPP4C in Homo sapiens

Synonym: PP4, PP4C, PPH3, PPP4, PPX, PPP4C

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP141_AA protein Get Run
HsapP141_AA_3-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 4-293 8.9e-123 403.3 In-house 27-328 (473) alignment 
Range on Protein: 4-293
Range on HMM: 27-328/473.0
ISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVR
..|||. ||.|....|..|.... |. .|.||| .|.|..... ...|.||||||..||..|..  |  ||....|.||.|||| .|.|...||||||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPDRITLIRGNHESRQITQVYGFYDECLRKYgSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDT
||....|.|||||.|.....|||.||.|.|| .. ..... | ...| |.|.|.|||..|||||||....|||||.|.| .|.|.||...|||||||...
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

TG--------WGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNET------VLTVWSAPNYCYRCGNVAAILELDEHLqKDFIIFEAA
 |        .| |||||||||| |.| .|   |..|.|.|.|. |.|||...|.        ..||.||||||.|.|| ||.|..||.|   ||.|...
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PQET
|.. 
phpl
subfamily_PPP4C_pd Subfamily PPP4C 5-292 7e-186 609.2 In-house 1-288 (288) alignment 
Range on Protein: 5-292
Range on HMM: 1-288/288.0
SDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRY
||||||||.|||||||||.|||||||||||||||||||||||||||||||||||||||.|||.||||||||||||.||||||||||||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTT
||||||||||||||||||||||||||||||||..|||||||.||||||.||||||||||||||||||.|||.||.|||||||||.||.||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQE
||.|||||||||||||||.|||.||||..|||||||||||||.||||.|||||||||||||||||||||||||.|.||| |||||..|
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 5-292 8.2e-158 517.1 In-house 2-289 (290) alignment 
Range on Protein: 5-292
Range on HMM: 2-289/290.0
SDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRY
.|||..||.|..|. ..|||||.|| ||.||| .||||| | .|||||||.||||.|| |||..||..|.|||||.||.||||.|||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTT
..|||..||||||||||||||||||||||||. .||.| |..||||.|.|..|..|||.||||||||.|||.||..|| |||||.||.||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQE
|||.||||||| || |.  .|| .|.. .| ||||||||||.| ... | |..||||||||||| |||||||..|.. |. |..||..
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
0049330 Metallo-dependent phosphatases 5-293 3.7e-114 373.9 In-house 15-303 (309) alignment 
Range on Protein: 5-293
Range on HMM: 15-303/309.0
SDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRY
|.||..||.|... |..|.|.. |. ||.||| .|.|..... ...|.||||||..||..|..  | .||....|.||.|||| .|.|..|||||||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRITLIRGNHESRQITQVYGFYDECLRKYGsVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPE-DT
||...|.|||||.|.....|||.||.||||| . .|..... ...| | |.|.|||.||||||||....||||| ..| .|.|.||..||||||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

TGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQET
 |.. .|||.|..|| ..| .|   |..|.|.|.|..|..||...|.. ..||.||||||.|.||..|.||.||.|   |..||..|...
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
0053225 Metallo-dependent phosphatases 5-290 1.6e-110 362.0 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRY
..||..||.|... |..|.|.. |. .|.|||..|.|..... ...|.|||||...||..|..  | .||....|.||.|||| .|.|...||||||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTT
||...|.|||||.......|||.||.|||||.  .|..... ...| |.|.|.|||..|||||||.. .||||| |.| ...|..|...||||||| . .
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAP
||. |.||.|..|| ..| .|  .|..|.|.|.||.|..||...|.. ..||.|||||..|.||..|.|.|||.|  .|..|.. .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP6C_pd Subfamily PPP6C 6-294 2.4e-152 499.1 In-house 1-289 (290) alignment 
Range on Protein: 6-294
Range on HMM: 1-289/290.0
DLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYP
.||. ||. ..|. . |...|.||..  ..|.|||||| | ||||||||||||||||.|||| ||.||.|.|.|.|||||||.||.||| .||.||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTG
|||||.||||||||||||||||||||.|||....|.|||..|| |...||||....|||||||| ..||||||.|.| ||.||.|..|||.||||||   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETR
| |||||||||||| |. .|.. |....||||||||.||.|..|.| . ||||||||||||||||.||.|... .... .|.| |.|.|
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP7C_pd Subfamily PPP7C 6-184 5.4e-38 123.7 In-house 19-203 (383) alignment 
Range on Protein: 6-184
Range on HMM: 19-203/383.0
DLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDS----PVTVCGDIHGQFYDLKELF-RVGGDVPETNYLFMGDFVDRGFYSVETFLLLLAL
.... ||.... .|..   |  .  .|...|..  |..|| .     ||||||.||.. ||  .. . |   .| .|.| |||||||  |||  |.||||
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KVRYPDRITLIRGNHESRQITQVYGFYDECLRKY--GSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSiQTLDQIRTIDRKQ
 . ||  . | |||||   .   |||  |   ||   .  . |   ..| .| |...|| ||. ||||.| .   |. .  |.|..
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkiersk
subfamily_PPG1_pd Subfamily PPG1 7-292 3.1e-137 449.8 In-house 1-299 (300) alignment 
Range on Protein: 7-292
Range on HMM: 1-299/300.0
LDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPD
||. .|.|...||. |. ||.|. | .|.||.||||... ||||| ||.||||||. |.|..||.||.|||||.||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYDECLRKY-GSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPE----
||||.|||||||||||||||| |||||| |  .||.| |||||||.|.|||| .|.|||||||||....|||. .|| .|||..| ..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DTTG--WGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQE
      |  |  . ||.||||| .| ||| .|   ||.. | |||||..|||. .|.. . |||||||||||||| |.|||| |.... | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 9-289 3.2e-96 314.9 In-house 13-294 (298) alignment 
Range on Protein: 9-289
Range on HMM: 13-294/298.0
RQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
  ... . .. |||..|. |...|..|. . . .  ||.|..||||||||. ||  ||  .|  |..||||.||.|||| ...|. .|||| ||.||...
vslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnf

TLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPED-TTGWG
 |.|||||  .| .|||||.|| |.| |....    ..|. | | |.| |.|.|.|||||. ...|||.|.. | .. ...    ||||.|||. ..|| 
fllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwa

VSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAA
 . ||... ||.|||...    |||...||||.| .||..  .  ..|..|||.|| .  | ||....||.|.  | ..  .
ensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPP3C_pd Subfamily PPP3C 15-278 2.9e-86 283.0 In-house 36-312 (452) alignment 
Range on Protein: 15-278
Range on HMM: 36-312/452.0
RRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGN
 .   ..|...  .  .| ..| .|... .|..|.||.|||||||||| .|| ||||  .|.|||.||.|||| .|.|. | |.|||. ||... |.|||
lkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGn

HESRQITQVYGFYDECLRKYgSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGV------
||.| .|. . | .||  || | .|.  |.| || | |.|..... .|||||||| |..||.|...|| .|.|. ||.|||||||| .  |         
hecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfv

--SPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFN------ETVLTVWSAPNYCYRCGNVAAILELDEH
  |.||  |...   |..|  .||.  | |||.   .||. . .       ...|..|||||.    | ||.|.... 
pnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 15-289 1.6e-84 276.4 In-house 3-275 (280) alignment 
Range on Protein: 15-289
Range on HMM: 3-275/280.0
RRCelIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGN
 .|  ||| .....  | ..||. .. .  ||.||.||||.|||. ||  ||   .  |..||||.||.|||| . .|  ||||| |||||... ..|||
lac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYDECLRKYgSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPE-DTTGWGVSPRGA
||  .| . |||.||. |.| |  ..    |..| | | |.. |.|.|.|||||. ...||... . |  . ...    ||||.||| ..|||. ..||.
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAA
 ..||..|| ..    |||.|.| ||.| .||..  .  ..||.|||.|.    | ||.| .||.|.  | ..  |
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 15-287 7.6e-77 251.5 In-house 18-293 (297) alignment 
Range on Protein: 15-287
Range on HMM: 18-293/297.0
RRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGN
  ...| |  |  |   | ...  . ..  |..|. ||||||||| ||  ||. ||  | .||||.||.|||| .|.|| .|||| ||..|  . |.|||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSP---SIQTLDQIRTIDRKQEVpHDGPMCDLLWSDPED-TTGWGVSP
||   . .|||||.|| ..| || ..    ..|..| |. .|  ||.|.||||||      ||| .| |.| .|  ... ..||||.||    .|.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFE
||||  || | | .  .  ..|..|||||.| .||..     ..|..||| || .  |.||..  ||.||  | |. 
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 17-293 7.3e-86 281.1 In-house 21-298 (299) alignment 
Range on Protein: 17-293
Range on HMM: 21-298/299.0
CELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
 . .|| |.. ||| |........ .  |..|. ||||||||. ||  .| . |  |..|.||.||.||||   .|.  |||. |..||.|. ..|||||
tksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDT-TGWGVSPRGAGY
   | .|||||.|| ..| |  .|    . |... |. .| ..|.|.|||||| .|||||.| . | |. |      ||||.||...  .|    ||  |
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

LFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQET
.|| ||||.     |||...||||.| .||..  .  ..|..||| || .  | |||...|| |   | ... .|.. 
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-284 1.5e-73 240.7 In-house 3-270 (280) alignment 
Range on Protein: 17-284
Range on HMM: 3-270/280.0
CELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
|...   |. |.      |..||||.   ..|. | |||| |. |.. || . | ||| . .|.||.||||   .| ..||..||.|| ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGsVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPED-TTGWGVSPRGAGY
.  . ..|||| ||  ||| | .|     .|. . .|..|  ...|.|||||| .  || || | |  |    | . ||||||| .   ||  | ||  |
tpsvnkiygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFI
.||  || |   . .||.| ||||.| .||.      ..||.| |||| .  | ||.. |.  ||  | 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 18-287 7.1e-83 271.3 In-house 6-281 (284) alignment 
Range on Protein: 18-287
Range on HMM: 6-281/284.0
ELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDV------PETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLI
.|.|| |.  || .|||.. .|.  . ...||...||||||| ||. |. . |         |..|||.||.|||| .|.|  .||.|.|...||...|.
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQVYGFYDECLRKYgSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDT-TGWGVSP
||||||| . . |||| || ..| |....      |  . |.|... ||.|.|||.|  .  |.|.  ..|  ..|  | ..|| |.||| . .|.  ||
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFE
|||| .||.. | .|.   ..|.. ||||.||.||..  .  ..|..||| || .  |.||.|..||.|   | ...
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 18-286 3.6e-64 209.5 In-house 14-286 (290) alignment 
Range on Protein: 18-286
Range on HMM: 14-286/290.0
ELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
. ......  .  |..|||     . .| .|... ||||||. .| . |   |  |. ..||.||.||||  |.|  |||. .|.||. .. |.||||| 
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

RQITQVYGFYDECLRKYGSvTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQ--EVPHDGPMCDLLWSDPED---TTGWGVSPRG
|.. ..|||..|  || ||  .|.   ..|. ||| | .. ||.|.|||.|. |.. . .... . .     ..| . ||||.||.     |      |.
rkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

AGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIF
   .|| ... ..     ...| |||..  ||... |.. ..||.||| |. .  |. ||... | |.  ....
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-70 1.2e-13 44.0 In-house 7-59 (317) alignment 
Range on Protein: 18-70
Range on HMM: 7-59/317.0
ELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGG
.|.||.|.  || .|||.. .|    ....|||..||||||| ||. |. . |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 18-68 1.4e-08 27.2 In-house 9-59 (339) alignment 
Range on Protein: 18-68
Range on HMM: 9-59/339.0
ELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRV
.|.  .|.  || .|||..  |  . ....|. | ||||||| ||  .. .
dlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldm
subfamily_PPP1C_pd Subfamily PPP1C 19-288 6.4e-108 353.2 In-house 9-278 (282) alignment 
Range on Protein: 19-288
Range on HMM: 9-278/282.0
LIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 .||.|..||..||||||.... . ... ||...||||||..||  ||  .|  ||.||||.||.||||  |.|| .||||.|..||... |.|||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGSVtVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPED-TTGWGVSPRGAGYLF
.|...||||||| |.|..  .|.  |..|..| |.|..| ||.||||||||... |.|||.| |  |||..| .||||||||.. ..||. . ||  . |
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEA
|.|||..| . ||.|.|.||||.| .||... .. ..||.|||||| . .| .|.|..||.|  .| |. .
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_PPZ_pd Subfamily PPZ 19-285 2.9e-78 256.4 In-house 24-290 (300) alignment 
Range on Protein: 19-285
Range on HMM: 24-290/300.0
LIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 .|.||.  .| ||||... . ..  .  .| . ||.|||. ||  ||   |  | .||||.||.||||  |.|| ||||. |..||. . |.|||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECLRKyGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTT-GWGVSPRGAGYLF
..|.|||||||| |.   . .|.   . |. | |.||. |||||||||||| ....|.|| . |  .||  | . ||||||| |..  |    ||  | .
nvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFII
    . .|     .|..|||| .| .||..  . ...||.||||||    |  |.. . | |   | .
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfel
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 19-287 2.2e-72 236.4 In-house 9-280 (287) alignment 
Range on Protein: 19-287
Range on HMM: 9-280/287.0
LIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 ......  .  |..|||   . . .|..|.|..||||||. ||  .|   |  |...|||.||.||||  |.|  |||..||..|| .. |.||||| .
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

QITQVYGFYDECLRKYGsVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQE--VPHDGPMCDLLWSDPED-TTGWGV-SPRGAG
.| ..|||..|  ||..   ...   ..|..|.| |... .|.|.|||.|| ...||..... . .     ..| . ||||.|||  . .  .   |.  
kinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirais

YLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFE
 .||  .| ..    |||.| |||... |||.. |.. ..||.||| |. .  |..|.. ... |.  |. . 
vvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 19-287 1.1e-70 231.3 In-house 2-272 (284) alignment 
Range on Protein: 19-287
Range on HMM: 2-272/284.0
LIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
||   .|..|  .| .|. ..  .  |.||. .|||||||| ||  ||   |    .||||.||.|||| . .|| |||.| || .|... ..|||||  
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

QITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPM-CDLLWSDPED-TTGWGVSPRGAGYL
 | ..||||.|| |.|   .|.     .|  . |.|..  .|.|.|||.|  .| . |.|.| |  . |    .  |.||||| .   ||    ||  |.
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyv

FGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFE
|||| . ..    .||.. ||||.| .||..  |  ..|..||| || .  | ||.. ... |   |... 
fgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlr
PPP_3 20-287 4.8e-122 399.2 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
IKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
..|.|.| |. |..||| .|||......|||||||||||..|| |||..||..|||.|||.||.|||| .|.|..|||||||..||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDL-LWSDPEDTTGWGVSPRGAGYLFG
|..||||..|.|.|.|. .|.....|.|..|.|.|.||.|...|||||||||..||||....||.|||..|...|| |.||||...|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFE
.||...|. .|....|.|||.|..|||. .... |.||.||||||.|..|..|||.|.|.|...| ..|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-279 4.4e-52 170.1 In-house 6-290 (302) alignment 
Range on Protein: 20-279
Range on HMM: 6-290/302.0
IKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVG--GD---------VPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ..||. .|. .  | | .|... .. .|||. ||||||| ||  ..      .           .  ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLRKYGSVT---VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRK-QEVPHDGPMCDLLWSDPEDTT
 |.|||||.. |   ||| .|   ..|      .|.   |.| .. |.|..  ||.|||||.|| ...|..|. |.|  .|| .|    |||..|| |. 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVSP----------RGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHL
.  . .          ||  ..|    | ..    ....| |||| . ||.|.. .. .||..|||.|     |  |.|..|   
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-279 5.7e-52 169.8 In-house 7-291 (302) alignment 
Range on Protein: 20-279
Range on HMM: 7-291/302.0
IKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVG--GD---------VPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ..||. .|. .  | | .|... .. .|||. ||||||| ||  ..      .           .  ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLRKYGSVT---VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRK-QEVPHDGPMCDLLWSDPEDTT
 |.|||||.. |   ||| .|   ..|      .|.   |.| .. |.|..  ||.|||||.|| ...|..|. |.|  .|| .|    |||..|| |. 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVSP----------RGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHL
.  . .          ||  ..|    | ..    ....| |||| . ||.|.. .. .||..|||.|     |  |.|..|   
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
PPP_1 21-274 2e-115 377.6 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
KESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
.|.|...|. |..|.|..|.|...|....||||||||||.|| .||.|||..|||||||.||.|||| .|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDL--------LWSDPEDTTGWGVSPRG
|.||||..|.|.|..| ......|..||.|.|.|.||.||..|||||||....|||||...||.|||..|..|||        |..|.|.....  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
||||||.||...|. .|....|.|||....|||.......|.|..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 21-288 1.5e-106 348.3 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
KESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
...||..|. ...||| .|.|. .|..||||.||||||..|| .|.. .| .||..|.|.||.|||| .|.|. |||.|||..||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDP-EDTTGWGVSPRGAGYLFGS
...|||..|. ||| .  ..  ..|.|..|.|.|..| ||.|.||||||....||.|| ..| .| |..|...||||||| ... |.  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEA
|.| .|  .|....|.|||..|.|||.. ... ..|..||||||....|.||.|.....|.  .. ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 21-289 1.1e-81 267.2 In-house 9-277 (281) alignment 
Range on Protein: 21-289
Range on HMM: 9-277/281.0
KESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
 . |....  ... |..||...  .|.|..| ||.|.|| |||.|| . | |||. ..|.||.||||  |.|...||..||.||.||| |.|||||  ..
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

TQVYGFYDECLRKYGsVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPED-TTGWGVSPRGAGYLFGS
 ..|||| ||  ||| . .|    . |. | .|| |. .. |.|||||| . .||..| . .  . .. | . ||||.||.. . .|  | ||....|| 
nkiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

DVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAA
.|| .     ....| ||||.|..||.      ..||.|.||||    | ||.| .|| |. ... .  |
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-291 4e-63 206.4 In-house 23-294 (307) alignment 
Range on Protein: 23-291
Range on HMM: 23-294/307.0
SEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQ
 |.. .  .|. |.  |  .  .| |. | ||.|||| || ..| . |  ||| |.| ||.||||. |.|. |||.. |. ||. | |.|||||  .. .
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

VYGFYDECLRKYGS--VTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDT-TGWGVSPRGAGYLFGS
 ||||.||.         .|      |. | .||.|  ||.|.||||||..  ||..|   .    |  | . |.||.||. .   |  | ||.|. ||.
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgt

DVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQ
.|. .      ...| ||||....||       ..|..||| ||    |  ..| .|| |  . . |  . .
nviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpese
subfamily_PPP5C_pd Subfamily PPP5C 25-290 3.3e-83 272.4 In-house 39-310 (322) alignment 
Range on Protein: 25-290
Range on HMM: 39-310/322.0
VKALCAKAREILVEESNVQRVD----SPVTVCGDIHGQFYDLKELFRVGGDVPET-NYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
. .. ..|.|.| ... .  ..    . .||||||||||||| ..|.. | . |.  ||| ||||||| .|||. |.||..|. ||... | |||||| .
alkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdn

ITQVYGFYDECLRKYGSvTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSP-SIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFG
. ..||| .|.  || . .|    ||.|..| |. .|. |.. |||||      |||..|.||| .. |..| ...||||||....| . | || |  ||
mnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfG

SDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILEL-DEHLQKDFIIFEAAP
 ||  .|   |....| |.|.. .|||. . .  ..||.|||||| . || .|...| ...|.  |  ||| .
pdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_PPPLV_pd Subfamily PPPLV 26-277 1.6e-54 178.2 In-house 3-277 (290) alignment 
Range on Protein: 26-277
Range on HMM: 3-277/290.0
KALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDL----KELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQIT
 .|| .| .||..| ..  ..||. | ||.||.. ||    | |.|.| |.  ...||.||.|||| .|||    |||||| || .. |.||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGSV--TVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDR---KQEVPHDG-PM-CDLLWSDPEDTT----------
. . .. |.  |.|     ||   ...||.| |.|.|| |.||||.|.  .|.|  .| .|.    . . . || |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GWG-VSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCgNVAAILELDE
  |.   . || |..|..| . .|   |... . |||.   .|..   .  .|||.|. .||    | ||.. .|.
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-287 1.7e-55 181.6 In-house 5-254 (263) alignment 
Range on Protein: 45-287
Range on HMM: 5-254/263.0
VDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSV----TVW
...|. .||| |||. ||  .|   |   .|.|||.||.|||| .|.|  .||..||.  | .. |.||||| . | . |||. |  ...       .|.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

RYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPM-CDLLWSDPE-DTTGWGVS-PRGAGYLFGSDVVAQFNAANDIDMICRA
 .  ..| |. | ||.  .|.|.|||.|| ...||.||.|    |  .  |. |||||.||| |. |.     |    .||   | ..    |||.| ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFE
||.|  || .  .  ..||.||  |     | ||.. ... |.  |. ..
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlk
Metallophos Calcineurin-like phosphoesterase 48-240 3e-47 154.5 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----KELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLL--LALKVRYPDRITLIRGNHESRQITQVYGFYDECL----------
...|.||.||...||     .|...... . ...||.||.|||| .| ||. ||  |.||...|... |.||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIrtidrkqevphdgpmcdllwsdpedttgwgv
                       ....   ..... |.|..|.| |..||||...||.||.| .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYLFGSDVVAQFNAANDIDMICRAHQL
    ...|||.|..  .   ...|...|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 9.1e-83 269.8 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFD
||||||.|||..|| .||..|...||..|||.||.|||| .|.|..|||||||..||....|.||||||.....||||..|.|.|.|. .|.....|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDL-----LWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQL
.|.|.|.||.|...||||||..|..||||....||.|.|..|...||     |....|.....  | ||||.|||.||....  .|....|.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 5.8e-78 254.5 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-KELFRVGGDVP-ETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKyGSVTVWRYCTEI
|||.||||||..||  .|...||. . |..|.|.||.|||| .|.|..|||||||..||....|.||||||......|||..|.|.|  . .........
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVP-HDGPMCDL-LWSDPE-DTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQL
||.|.|.|.||.|...||||||.....||.|..|.||.|.| ... ..|| |||||. ...|.  | ||||.|||.||. .|  .|....|.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 1.5e-76 249.8 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-KELFRVGGDVP-ETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEI
||||||.|||..||  .||. ||| . |..|.|.||.|||| .|.|..|||||||..||....|.|||||..|....|||..|.|.||..  ........
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVP-HDGPMCDL-LWSDPE-DTTG-WGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQL
||.|.|.|.||.|...|||||||.|....... |.||.|.| ..| ..|| |||||. ...| .  | ||||.||| ||. .|   |....|.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-287 2e-70 230.5 In-house 101-313 (317) alignment 
Range on Protein: 75-287
Range on HMM: 101-313/317.0
TNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYgSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTL
 .|||.||.|||| .|.|  .||.|||..|||...|.||||||| . . |||| |. ..| |....     .|  | |.|... ||.|.|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRTIDRKQEVPHDGPMCDLLWSDPEDT-TGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAIL
.|. ...|  ..|  | ..|| |.||. . .|.  |.|||| .||.. | .|.   |.|.. ||||.|..||..  .  ..|..|||.|| .  |.||.|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDEHLQKDFIIFE
..|..|.  . ...
svdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-287 2e-54 177.9 In-house 121-332 (339) alignment 
Range on Protein: 76-287
Range on HMM: 121-332/339.0
NYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSvTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLD
 |||.||.|||| .|.|  .|| |||. ||||| |.||||||| .   |||| |   .| .  ..    ..|. . . |.|.  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRTIDRKQEVPHDGPMCDLLWSDPEDT-TGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
|.  . |  |.|  | . || |.||. |  |.  | ||| ..||   .  |    |..|. | ||.| .||..     ..|..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDEHLQKDFIIFE
.|..|.    .| 
idkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 192-294 1.2e-19 63.3 In-house 237-339 (383) alignment 
Range on Protein: 192-294
Range on HMM: 237-339/383.0
MCDLLWSDPEDTTG-WGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAp
. |.|||||. ..| .  . ||.|  ||.|| ... .  ..... |.|.  .|||..  ...|||..|| ||     |  | . | ..|.  .. . |. 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas.

QETR
..|.
katk