Gene ACP6 in Homo sapiens

Synonym: ACPL1, LPAP, PACPL1, UNQ205/PRO231, ACP6

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP161_AA protein Get Run
HsapP161_AA_47-421 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP6_pd Subfamily ACP6 48-420 4.9e-177 580.2 In-house 2-375 (376) alignment 
Range on Protein: 48-420
Range on HMM: 2-375/376.0
LKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDI
|.||.||||||||||.|.|.|| ||.|||...|||..|....||.||||.|.|||.|.....|....||||.|.||||||||||.|.||..|||.|||||
leLkqvqvvfrhGartPikslPqeeeveWdkdlleslpdleidyrvtnlnGepkPeskieekykkeilkGGafkGqLtkvGmqqvfdLGrkLrkrYvedi

PFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQ---CQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSS
.|||..||||||.||||||.|.|||.|||.|||..   .|||.|||..|||.|.||||||.|.|..|....|..|..|...||||||.|...|...|...
kfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiilytdeedeevlyPnrqrcpllsrayrsvrksaislpGisedtkqiadvldisee

DKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDR---ESLQMAVGPFLHILESNLLKAMDSATAPdkiRKLYLYAAHDVTFIPL
.|.||..|.||.||..||||...|.||.....||..||......|...||   |.|...||..|.....|| ||.......   |||.||.|||.|...|
kkldfvslrDniaArlaHnlkvppilkdvidliekhAveelvvlleggdrpekeilklsvGkvlkeilenlekakekeipa...rklrLysaHDttlmtL

LMTLGIFDHKWPPFAVDLTMELYQHlESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLsPEKYHALCSQTQ
|..||.||.||||||.|...|||.. ...|.||...|..||...||....|.||..| ....|..| |..|.| |....
LlalgvFDdkWPpfaadvileLyed.kageyfvrvlYqekelrlrgseedlvPlekFkallavlvl.pkdyaaeCkled
0048946 Phosphoglycerate mutase-like 48-419 2.7e-66 217.3 In-house 39-412 (447) alignment 
Range on Protein: 48-419
Range on HMM: 39-412/447.0
LKLKMVQVVFRHGARSPLKPLPLeeQVEWNPQLLEvppqtqfDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFaGQLTKVGMQQMFALGERLRKNYvedI
..||.|||.||||||.|.|. .   ..|.  .||.       ...|..| |. . .  .. |..  .| .  . |||| .|..|.. ||.|||| |    
celkqvqvlfRHGaRtPtkkylk..gleplldllk.......nanvlelggdlsflndwkyqlkneplwpcgl.gqLTplGreqlyelGkrlrkrY...l

PFLSptfNPQEVFIRSTNIFRNLESTRCLLAGLFQCQ---KEGPIIIHTDEADS-EVLYPnyqSCWSLRQRTRGRRQtASLQPGISEDLKKVKDRMGIDS
..|.   ||.|...||... | |.| ...|||||. .   .  ||.|||.. .  ..|.|   ||  . . ...  . ..|.  ..| |...|.  | . 
gllp...npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp...sCpafkellkkela.eelkellkellerlkkllggln

SDKVDFFILLDNVAAE-QAHNLPSCP---MLKRFARMieQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATapdkirKLYLYAAHDVTFI
 .  |.. | | ...| ..|.|.  .     . . ..  ... | . | .   ..|  ..| ||.|. . ..| .|... .      ||||| ||| | .
ltlsdvydlydlllyetaihglsplcslftpeelevl..eyladlefyyeygygdelarlaggpllneilarledaisgds......klylyfaHdttia

PLLMTLGIFDHKWP------------------PFAVDLTMELYQHLE----SKEWFVQLYYHGKEQVPRGCPDG---LCPLDMFLNAMSVYtLSpeKYHA
.||..||.||...|                  |.|  |..|||.. .    ..|..|...| |...   ||..|   ||||| |.. .. . |.   .  
allsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplplpgCgsgpgglCplddFkellkkf.lp..dwek

LCSQT
||  |
lCglt
0049059 Phosphoglycerate mutase-like 48-416 3e-65 213.8 In-house 41-434 (435) alignment 
Range on Protein: 48-416
Range on HMM: 41-434/435.0
LKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTqfdytvtnlaggpkpyspyDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYvedi
..||.|||.||||||.|.. |. . .. |.  |  ..  .                   ..    .  .. . ||.|| .|..|.. ||.|||| |    
celkqvqvlfRHGaRtPtsklikklealwekllslltypn...................gplsflndwnyplgageLTplGreqayelGkrlrkrY....

PFLsptFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQ-----------KEGPIIIHTDEADSEVLypNYQSCWSLRQRTRGRRQTASL----QPGISEDL
.||   .||.||..||... | |.| ...|||||. .              |..|.|...|   |  .|.||. . .  ..  ...       . |.. |
gfL...ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpafdellkellasdeflelflerilkll

KKVKDRMGIDSSDKVDFFIL--LDNVAAEQAHN--LPSCP--MLKRFARMIeqRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDK--
... ...|.. ||  |.. |   |......||.  || |.    . . ..   .. |   | |   ..|  ..| ||.|. . ..| .|... . . .  
qellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevle..yladlefyylygygdeiaklaggpllneilarledaingdstnlnlt

----------IRKLYLYAAHDVTFIPLLMTLGIFDHKWP---------------------PFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDG--
           .||||| ||| | .|||..||.||...|                     |.|  |..|||..  ..|..|...| ||..   ||..|  
ldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVrvlyngkvlplpgcgsgpg

-LCPLDMFLNAMSVYtLSPeKYHALC
 ||||| |.. .. . |..  .. .|
glCplddFkelvkkf.lpg.ddfdeC
0047369 Phosphoglycerate mutase-like 48-416 7.1e-64 209.5 In-house 42-436 (438) alignment 
Range on Protein: 48-416
Range on HMM: 42-436/438.0
LKLKMVQVVFRHGARSPLKPLPLEEQVEWNpQLLEVPPQTQfdytvtnlaggpkpyspyDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYvedi
..||.|||.||||||.|.| .. ... .|.  |... . .                   ..    ....| . ||||| .|..|...||.|||| |    
celkqvqvlfRHGaRtPtksklkkleplwe.llenattyps..................gplsflndwlgpcgagqLTplGreqayelGkrlrkrY....

PFLsptfNPQEV-FIRSTNIFRNLESTRCLLAGLFQCQKEG--------PIIIHTDEADSEVLYP--NYQSCWSLRQRTRGRRQTASLQP----GISEDL
..|    ||..| ..||... | |.| ...|||||. ...|        || |||.  ....|..  ...||  ...  ... .... .      |.. |
glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrl

KKVKDRMGIDSSDKVDFFILL-DNVAAEQAHNLPSCPMLKRF----ARMIEqRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDK---
||. . .... || .|.. |. .. .| . ..|| .|... |    .. .|  . |   | |   ..|  ..| ||.|. . ..| .|... . . .   
kkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevle.yladlefyylygygnelaklaggpllneilarledaingkstnlnltl

---------IRKLYLYAAHDVTFIPLLMTLGIFDHKWP---------------------PFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDG---
          .||||| |||.|...||..||.||..||                     |.|  |..|||.. ...|..|...| ||..   ||..|   
dsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvlyngkvlplpgcgsgpgg

LCPLDMFLNAMSVYtlSPEKYHALC
||||| |.. .. .   |. .. ||
lCplddFkelvkkl..lpgdfeelC
0048439 Phosphoglycerate mutase-like 48-403 4e-63 207.0 In-house 7-387 (391) alignment 
Range on Protein: 48-403
Range on HMM: 7-387/391.0
LKLKMVQVVFRHGARSPLKPLPLEEQVEWNPqllevppqtqfdytvtnlaggpkpyspydsqyheTTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEdI
..||.|||.||||||.|.. .| ...  .|                                   ... |.  .|.|| .|..|...||.|||| ||.  
celkqvqvlfRHGaRtPtssypnkldpllnk..................................llpngpcglgeLTplGreqlyelGrrlrkrYvd.l

PFLSPTF--NPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPN-YQSCWSLRQRTRGRRQTASLQ-------PGISEDLKKVKD
 .|....  ||.||..||... | |.| ...|||||. ..  .|.. . | ....|.|. ...|. |.. .. . ..|  .       . ..| |..|..
gllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlg

RMGIDS-----------------------SDKVDFFILLDNVAAEQAHNLPSCPM-LKRF-----ARMIEQRaVDTSLYILPKEDrESLQMAVGPFLHIL
 . ...                       |.  |.| | |.. .|.||.||  .  ....     ....    |.  .| |   . |  ..| ||.|. .
lnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladl.vnelyyyltgsg.eiaklaggpllnei

ESNLlkamdsATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDH------KWPPFAVDLTMELYQHLESKEWFVQLYYHGK--------------------E
 ..|      ... .. .||||| ||| |...||..||.|..      ..||.|  |..|||.. ...|..|...|.|.                     
lddl......vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldefllrlv

QVPRGCPDG---LCPLDMFLNAMS
..  ||..|   ||||| |.. ..
lplpgcgsgpgglCplddFvelvk
subfamily_ACP2_pd Subfamily ACP2 48-419 2e-60 197.2 In-house 7-359 (361) alignment 
Range on Protein: 48-419
Range on HMM: 7-359/361.0
LKLKMVQVVFRHGARSPLKPLPLEEqvewnpqllevppqtqfdytvtnlaggpkpyspydsqYHETTLKGGMfaGQLTKVGMQQMFALGERLRKNYVEDI
 |||.|||.||||.||||...| ..                                     | |..  .|.  ||||. ||||.. ||. ||| |||| 
rkLkfvqvlfRHGdRsPlntypndk.....................................ykedewpqgl..GqLTeeGmqqqyeLGkfLrkrYvedt

PFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEG---------PIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDL---KKV
 ||....||.....||... | |.| ...|||||. ...          |. .|| ......|  . ..|   ..  .  .... ..  ..|     .|.
kfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevkklleenkellekl

KDRMGiDSSDKVDFFILLDNVAAEQA-HN-LPSCPMLKR-FARMIEQ---RAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKiRKLY
... |  . |. .|. | |..  |.. .| |.  ....  . ...|.    .     ..  ...||  ..  ||.|. | .|. .. . .  ..| .||.
sestg.edidlenfyqlsdtlicerkyanelnlpewandelfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkk.lklf

LYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHlESKEWFVQLYYHGKEQVPRG------CP-DGLCPLDMFLNAMSVYTLSPekYHALCSQT
||.||| |  .||..||||..|.||.|  . .|||.. .... .|...|. ... ..       |. . .|||. | . .. ....   .. ||  .
lYSaHDttlaalLeaLgifekkappyasaiivElyee.ddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipdd..vdelCeak
subfamily_PXYLP1_pd Subfamily PXYLP1 48-417 3e-24 77.0 In-house 22-417 (419) alignment 
Range on Protein: 48-417
Range on HMM: 22-417/419.0
LKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPP-----QTQFDYTVTNLAGGPKP---YSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERL
 ||| | || ||| | ||. .|  .. |.| .| .          .| .  .  | | .     .|..|     . ...   ||||..|. |.. .|. |
fkLkavlvvirhGDrtPlsdipkskraeinCdlsaasknlvdklksfldnssseasgsdfenkvgplkslPllpnheriCelgqLtqkGvvqhLevGdll

RKNYVEDIPFL--SPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTdeADSEVLYPNYQSCWSLRQRTR-GRRQTASLQPGISEDLKKVK
|| | .   .|     ..  || . .|.  | | |.  || ||.. .|   | ...    |     .  || .|... .    . . |. |   |..|  
rkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpkaklkairvre..spsvafClgeCsCPallrkrlekeadkqlLlrgkvldvmksv

DR--MGIDSSD-KVDFFILLDNVAAEQAHNLPsCPMLKrfARMIEQRAVDTSLYILPK----EDRESLQMAVGP-FLHILESNLLKAMDSATAPDKIRKL
 .   |..    .      .| . .   ||..  |. .     .|   ||.   ..      . ..|    .|  . . |  .... |  ..   .  | 
getlkgtilqttlngisnpvdalltvlChnvs.lPcrr..eGcvepshvdvlhkladelsqrsakksyyklsGllraypllrdivsrmlkiieGvdkekf

YLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVP---------RGCPDGLCPLDM---FLNAMSVYTLSPEKYHALC
 ||..||||. ||. .||. . ... .|  | .|||.  .|||..... |.||..           .. ...||||.    |..   . .|| ..|.  |
vlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDvtqkvdfCegdskrskkdlCPlenlvrfvkkdyfsalsatnykdaC

S
.
t
0046349 Phosphoglycerate mutase-like 49-421 8e-70 229.0 In-house 6-395 (409) alignment 
Range on Protein: 49-421
Range on HMM: 6-395/409.0
KLKMVQVVFRHGARSPLKPlpleeqvewnpqllevppqtqfdytvT-----------NlaggpkpyspydsqyhettlKGGMFAGQLTKVGMQQMFALGE
.||.|||.||||||.|.|                           .                                 |.. ||||| .|..|...||.
eLkqvqvlfRHGaRtPtkk..........................lsflpnwpginwt....................ngpcgagqLTplGreqayelGk

RLRKNYVEdIPFLSPT--FNPQEVFIRSTNIFRNLESTRCLLAGLF-QCQKEG--------------PIIIHTDEAD-----SEVLYPNYQSCWSLRQRT
|||| ||. . .|...  .||.|...||... | |.| ...||||| ... |               ||.|.|  ..     ...|.|....|  | . .
rlrkrYvd.lgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkll

RGRRQT-AS--------------LQPGISEDLKKVKDRM-----GIDSSDKVDFFI-LLDNVAAEQAHNLPSCP----MLKRFARMIEQrAVDTSLYILP
.   .. .               | . . . |||. .|.     |.. .|  |..  | |. ..|.||.||  |    . .. .. ..  . | . |.| 
kenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlay.ladleyyyly

KEDrESLQMAVGPFLHILESNLLKAMDSATAPDKI--RKLYLYAAHDVTFIPLLMTLGIFD-----HKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQ
... |  ..| ||.|. . ..| .|... . .. .  .|||||.|||.|...||..||.||     ...||.|  |..|||.. ...|..|...|.|...
gsg.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlynggpl

VPRGCPDGlCPLDMFLNAMSVYTLSPE--KYHALCSQTQV
   ||..| |||. |.. .. .  . .   .  ||. .. 
plpgcgeg.cplsefkellkkrlpgcgltdfdklCpledf
0049226 Phosphoglycerate mutase-like 49-416 3.5e-66 216.7 In-house 2-340 (342) alignment 
Range on Protein: 49-416
Range on HMM: 2-340/342.0
KLKMVQVVFRHGARSPLKPLPLEEQVEWNpqllevppqtqfdytvtnlaggpkpyspydsqyhettlkGGMFAGQLTKVGMQQMFALGERLRKNYvedIP
|||.|||..|||.|.||. .||..  ||.                                       .|. .|.|| .|..|...||.|||| |     
kLkqvqvliRHGdRtPlakgpldflnewf.......................................wgcglgeLTplGreqayelGrrlrkrY...lg

FLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEG----------PIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASL---QPGISEDLKKV
.|..|.||.||..||... | |.| ...|||||. .. .          . || ..|. . .|...|.||  . .  .   ... .    . | . |||.
llpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkkl

KDRMGIDSSDKVDFFI-LLDNVAAEQAHNLPSCPMLKRF--ARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDsataPDKIRKLYLYA
....|.. |. .|..  | |....|.||.||  | .. |    ...  |.|.  | .   ..|  ..| ||.|. . ..| .|..    . . .||||| 
skllglnlstlsdvadtlydlllyelahglplppwcslftleelkalyaldllyyygigygeeiarlaggpllneilarleeaie....gpsdlklylyf

AHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHleSKEWFVQLYYHGKE------QVPRGCpDGLCPLDMFLNAMSVYTLSpeKYHALC
|||.|...||..||.||...||.|  |..|||..  ..|..|...|.|.       .   || ||||||| |.. .. .. .   .  ||
ahdttiaallsalglfddqlPpyasnlvfElyec..dgeyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkkflpg..dfeelC
0053031 Phosphoglycerate mutase-like 49-416 1.4e-62 205.0 In-house 2-340 (342) alignment 
Range on Protein: 49-416
Range on HMM: 2-340/342.0
KLKMVQVVFRHGARSPLKPLPLEEQVEWNPqllevppqtqfdytvtnlaggpkpyspydsqyhettlkgGMFAGQLTKVGMQQMFALGERLRKNYvedIP
.||.|.|..|||||.||  .||..  ||.                                        .. ||.|| .|..|...||.|||| |     
eLkqvivlvRHGaRtPlskgpldplnewfy.......................................pcgageLTplGreqayelGrrlrkrY...lg

FLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGP---------IIIHTDEAD-SEVLYPNYQSCWSLRQRTRGRRQTAS---LQPGISEDLKKV
.|..|.||.||..||... | |.| ...|||||. .. .          | ||| ... . .|.|||..|. . .   .. ...    | . ..| |.|.
llpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqkl

KDRMGIDSSDKVD-FFILLDNVAAEQAHNLPSCPMLKR--FARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSataPDKIrKLYLYA
 ...|.. || .| .. | |....|.||.||  | ..   . ...   |.|.  |      .|  ..| ||.|. . ..| ... .   |... ||||| 
skglgltlsdlldlvsdlydlllyelahglplppwctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisg...pldl.klylyf

AHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLesKEWFVQLYYHGK------EQVPRGCpDGLCPLDMFLNAMSVYTLSpeKYHALC
||| |...||..||.||...||.|  |..|||..   .|..|...|.|.      ..   || ||||||. |.. .. . ..   .  ||
ahdttiaallsaLglfddqlPpyasnlvfElyedp..geyyVrvlynggtlseplvlplpgc.dglcplsefkelvkkllpg..dfeklC
His_Phos_2 Histidine phosphatase superfamily (branch 2) 49-379 2.2e-53 174.3 Pfam-A 1-347 (347) alignment 
Range on Protein: 49-379
Range on HMM: 1-347/347.0
KLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEvppqtqfdytvtnLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVediP
.||.|.||.|||.|.|..  ... . |.. .||.             |.. ....  .  ....  |.  . .|.||. |..|...|||.||..|.    
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk.............lknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp...g

FLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQK------------EGPIIIHTDE----ADSEVLYPNYQSCWSLRQ-----RTRGRRQTASLQPG
.|.. .....|.|||..  | |.| ....|||.. ..              .. ..| .    ...|.| ....||. ...      .| . ....|.. 
llrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkv

ISEDLK-KVKDR-MGIDSSDKVDFFILLDNVAAEQA--HNLPSCPMLKR----FARMIEQRAVDTsLYILPKEDRESLQMAVGPFLHILESNLLKAMDSA
. |.|. ....   | |. .  .   .|.. . |.   .... . . .     .. . . ..... || | .  .|  .   ...|. | ...|....  
mdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledlee.lyklygigdeeklkigllllnpllkkilsdleet

TaPDKIRKLYLYAAHDVTFIPLLMTLGIFD------HKWPPFAVDLTMELYQHlESKEWFVQLYYH
. |.. .||.||..|| . ..||..||...      ....|.|  ...|||.. . |...|.|...
q.psrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyed.sekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 49-379 2.2e-53 174.3 In-house 1-347 (347) alignment 
Range on Protein: 49-379
Range on HMM: 1-347/347.0
KLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEvppqtqfdytvtnLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVediP
.||.|.||.|||.|.|..  ... . |.. .||.             |.. ....  .  ....  |.  . .|.||. |..|...|||.||..|.    
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk.............lknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp...g

FLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQK------------EGPIIIHTDE----ADSEVLYPNYQSCWSLRQ-----RTRGRRQTASLQPG
.|.. .....|.|||..  | |.| ....|||.. ..              .. ..| .    ...|.| ....||. ...      .| . ....|.. 
llrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkv

ISEDLK-KVKDR-MGIDSSDKVDFFILLDNVAAEQA--HNLPSCPMLKR----FARMIEQRAVDTsLYILPKEDRESLQMAVGPFLHILESNLLKAMDSA
. |.|. ....   | |. .  .   .|.. . |.   .... . . .     .. . . ..... || | .  .|  .   ...|. | ...|....  
mdenlakrlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrqledlee.lyklygigdeeklkigllllnpllkkilsdleet

TaPDKIRKLYLYAAHDVTFIPLLMTLGIFD------HKWPPFAVDLTMELYQHlESKEWFVQLYYH
. |.. .||.||..|| . ..||..||...      ....|.|  ...|||.. . |...|.|...
q.psrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyed.sekkfyvrllfs
subfamily_MINPP1_pd Subfamily MINPP1 49-239 4e-08 24.5 In-house 30-215 (420) alignment 
Range on Protein: 49-239
Range on HMM: 30-215/420.0
KLKMVQVVFRHGARSPLKPLPLEEQVEWNpQLLEVPPQTQ-FDYTVT-NLAggpkpyspydsqyhETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEd
||. .|...||| | | |    . | ... .. .   |.. .. ... .|.              ..      ....|.. | ...  |..|| ... . 
klvklqiiaRHGtRypskskikkiqetle.kiknyseqldgklsilnedle..............snleyetelekslvaqgqeeleelakrlarrfpa.

ipFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGL-----FQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQ------PGISEDLKKV
  ...   ||... ..||.. | ..|    . ||        ..  .. . . |..|. |   ..|| .  .  . .  .   .      . ... |...
..lfeevynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqesdklLrffdsCkkyknkvkknelnlkeeeefleskelqkaleei

KDRM
..|.
akrl
subfamily_HP2-Group1_pd Subfamily HP2-Group1 115-182 5.4e-12 36.8 In-house 86-152 (422) alignment 
Range on Protein: 115-182
Range on HMM: 86-152/422.0
LKGGMFAGQLTKVGMQQMFALGERLRKNYVEDiPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQ
 .|    .||| .| .|  . |. ||| ||..  || ..... ||..|| .. | . |...|. |.. 
daGdcavaqltleGykqqelnGqilrkvyvdt.GflkssldssevylrsddesrtilsaqalilGmyp
subfamily_HP2-Group1_pd Subfamily HP2-Group1 252-416 1.7e-14 44.9 In-house 251-416 (422) alignment 
Range on Protein: 252-416
Range on HMM: 251-416/422.0
LLDNVAAEQAHNLPSCPMLK--RFARMIEQRA-VDTSLYILPKEDReSLQMAVGPFLhileSNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIF
| | . . | ||.   . |    . |....      | .  |  ..   .. .| .|     .. | .  . . ...||. ||. || |.|.|| .|.. 
lvdclithqchnaaipdkltedlakrgldellyrsysslkypsvek.yarvGiGfll....kdiwkevnesltGedlrkfllysGhdttliqllsalnvd

DHKWPPFAVDLTMELYQHLESKE-----WFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSvyTLSPEK-YHAlC
. ||||.|  | .||..   . .     . |.. | || .    |    |... | . .|  |. |.. ..  |
efkwppyasllllellevstapaastpqyavrvlynGklkklpfcdanecsyeqfeayls..tviphddaed.c