Gene CDC25A in Homo sapiens

Synonym: CDC25A2, CDC25A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC3
Superfamily CC3
Family CDC25
Subfamily CDC25
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP188_AA protein Get Run
HsapP188_AA_366-478 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
M-inducer_phosp M-phase inducer phosphatase 86-329 5.2e-95 306.0 Pfam-A 1-259 (259) alignment 
Range on Protein: 86-329
Range on HMM: 1-259/259.0
LDSPGPLDSKENLE-----------NPMRRIHSLPQKLLGCSPALKRSHSDSLDH-----DifQLIDPDENKENEAFEFKKPVRPVsrgcLHSHGLQEGK
|||||||||||. |           .|.|||.||||||||.|||||||.||.||.     |  .||...||||||.|||||||.||    |......|.|
LdspgpldskeaeeaipdaarvkkkiplrrinslpqkllgssPalkrsasdaldsekrkad..alisssenKENegfefKkpvkpv....lrallwaerk

DLFTQRQNSAPARMLSSN-ERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTN-------LDNRCKLFDS
.|..|||.||||.||||. |....| |....|..|.|.|..| ..||||||||||.|.||.|.|.||.||||..||||.....       |..||.|..|
ellvqrqssapalmlsspeekveveegemkalgspistvsktdkeeDDGFvDlldaeelkdeleepsgmasLlsaPLvkkleeeeekdlillsrcrLyrs

PSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSG-ASPK-ESTNPEKaheTLhqSLSLASSPKGTIENI
|||..|.||.||||.||...|..| ..|||||.|  ...| |...|.|   ..  ||...|..|..||.|
pslpesltrpvLKrverpkdeetPvkvKrrksvsspveekeeaeepkk...rv..slrskSlckveieti
Subfamily.CDC25.PD 367-478 1.5e-48 155.1 In-house 2-116 (117) alignment 
Range on Protein: 367-478
Range on HMM: 2-116/117.0
SVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP-TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPEL
..|.|....||....|||||||||||||||||||||...||.|...||.| |. .. ||.||.|||||||||||...|..||.||  |  |||||.||||
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YVLKGGYKEFFMKCQ
|.|.||||||| ...
ylLegGykeffeeve
Family.CDC25.PD 367-478 1.5e-48 155.1 In-house 2-116 (117) alignment 
Range on Protein: 367-478
Range on HMM: 2-116/117.0
SVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP-TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPEL
..|.|....||....|||||||||||||||||||||...||.|...||.| |. .. ||.||.|||||||||||...|..||.||  |  |||||.||||
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YVLKGGYKEFFMKCQ
|.|.||||||| ...
ylLegGykeffeeve
Group.Cx5R-II.PD 367-478 1.5e-48 155.1 In-house 2-116 (117) alignment 
Range on Protein: 367-478
Range on HMM: 2-116/117.0
SVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP-TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPEL
..|.|....||....|||||||||||||||||||||...||.|...||.| |. .. ||.||.|||||||||||...|..||.||  |  |||||.||||
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YVLKGGYKEFFMKCQ
|.|.||||||| ...
ylLegGykeffeeve
subfamily_CDC25_pd Subfamily CDC25 369-478 1.5e-49 158.0 In-house 2-113 (114) alignment 
Range on Protein: 369-478
Range on HMM: 2-113/114.0
LNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPELYVL
|.|.|.. |.|..|||||||||||||||||||||...||||..||||| |... || |..|||||||||||...|..||.||  |  |||||.|||||.|
lkgefeekiaevliiDcRypyEyegGHikgavnlysreeveeellkkpkvkseekrkiiifhCefsseRgPklarllrevdrelnkeeypkleypelyll

KGGYKEFFMKCQ
..||||||....
ekGYkeffeeve
subfamily_Acr2_pd Subfamily Acr2 370-473 2.7e-09 27.5 In-house 3-108 (113) alignment 
Range on Protein: 370-473
Range on HMM: 3-108/113.0
NGKFANLIKEFVIIDCRYpYEYEGGHIKGAVNLHMEEEVEDFL----LKKPIVP--TDGK-RVIVVFHCEFSSERGPRMC-RYVRERDRlgneyPKLHYP
.|.  .| ..| ..| |   .| ..||| |  . .   ..|      ||| ..   .|..  . |.|||  | .|||..    .|  |       .|   
eGlietlredfqvvdvrr.edyardhikdawhvavsrlkqdkeylrelkkrllekqadsrgalkvifhctlskqrGPkvamlllrsldt.....aelsrc

ELYVLKGGYKEF
 |.||.||.  |
rlwvlrggfskf
Rhodanese Rhodanese-like domain 372-473 3.2e-17 55.1 Pfam-A 4-110 (113) alignment 
Range on Protein: 372-473
Range on HMM: 4-110/113.0
KFANLI--KEFVIIDCRYPYEYEGGHIKGAVNLHM-----------EEEVEDFLLKKPIVPTDGKRVivVFHCeFSSERGPRMCRYVRERDRLGNEYPkl
....|.  ...|..|.| |.||..|||.||||.             ... .. | .. .   . |.|  |..| .|..|. .... ...     . |.  
elkellekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktv..vvyc.rsgnrsggaaalllalilkelgyk..

hypELYVLKGGYKEF
   . |||.||....
...nvyvLdGGfeaw