Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| PhoD | PhoD-like phosphatase | 93-181 | 4.3e-09 | 26.8 | Pfam-A | 62-150 (453) | alignment | ||
Range on Protein: 93-181
Range on HMM: 62-150/453.0
LIHHANMTGLEPNTQYFYRCGG--KQGTSTTFNFTTPpPLGSVEEpLYIAMIGDLGQTTDSISTLDHIRADFEAHITVLVGDLSYADSAEQ
. ....|||||...|||| .. .| . ...| | ..||. | .|.... .. .......... . . . .|| |......
ytvkvevtgLepgqeyfYrfraeegesespvGrtrTl.peaaves.lrlavvSCsnyeqGyfnayrelaekedlDfvlhlGDyiYeygegt
|
|||||||||
| Metallophos | Calcineurin-like phosphoesterase | 139-345 | 1.1e-21 | 71.0 | Pfam-A | 3-200 (200) | alignment | ||
Range on Protein: 139-345
Range on HMM: 3-200/200.0
IAMIGDLGQTTDSI----STLDHIRADFEAHITVLVGDLSYADSAEQNEPTRNCtqkrwdswgQIVEPYFAYQPLMVLPGNHEVEQVGPL-PATQEQFL-
|. ||||. . | |..|.|. .. . . |||.... . . . . |.. ... |...|.||||. ... ... ||.
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalld.........ylvlklllpipvfllrGNHesdpgnsaygflleqlkd
---------AYQSRfrmpspssgsnsgNlyYSFNIGPAHYIMLNSYMDFNHSDPQYMWLEEDLRKVDRTVTPWVVCNMHAPWYNSDVHHHDEYEETAMRA
.|... . . . .. |.. .. . |...|||.|....|. ..... .|.|.. |. ...|. | ..
lrglangeeeyenl.............k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpd
SMEDLLHQYRVDFVFSGHVHAY
.|.|| .|.|| |..||.| .
alekllekygvdlvlrGHtHkp
|
|||||||||
| Metallophos_2 | Calcineurin-like phosphoesterase superfamily domain | 139-375 | 8e-09 | 27.7 | Pfam-A | 3-144 (156) | alignment | ||
Range on Protein: 139-375
Range on HMM: 3-144/156.0
IAMIGDLGQTTDSISTL-DHIrADfeAHITVLVGDlsyadS--AeqneptrnctqkrwdswGQIVEPYFAYqPLMVLPGNHEVEQvgpLPATQEQFLayq
||.|.|| |..... ..| . . . . .|| . ..|| .. |. ...|||. .. ||.... |
iaiiSDlHgnldaleavledi.ke..vdlilhaGD.....lvep.................eevvelledi.pvlavrGnhDeae...lpkelavel...
srfrmpspssgsnsgnlyysfnigpahyimlnsymdfnhsdpqymwleeD----------LrkvdrtvtpwvvcnmhapwyNSDVHHHDEYEETAMRASM
. . | ... . ... .
.................................................llaaaaleiegd....................rvllvhgtplsvqsseeel
EDLLHQYRVDFVFSGHVHAYERmyptynnkTDPTGTTYINIGDGGN-REGP
. || ....|.||.||.| .. .. .||...| | |. |||.
aellkeagadlvflGHtHkpkv........ekrggtlvvnpGsvgepregd
|
|||||||||
| PAPL | 140-345 | 3.7e-50 | 162.8 | In-house | 1-194 (194) | alignment | |||
Range on Protein: 140-345
Range on HMM: 1-194/194.0
AMIGDLGQTTDSI-STLDHIRADFEAHITVLVGDLSYADSaeqneptrncTQKRWDSWG--QIVEPYFAYQPLMVLPGNHEVEQvgplpatqeQFLAYQS
|..||||||. | ..| . .. . . ..||||.|||. .|..||... . .||..|. |.||.||||| |. .| .|..
avfGDlGqtnasslkrlqketqkgkydailhvGDlaYadd..........eqnewdgdefmrqieplaasvpymvapGNHEeey.........nfsnyka
RFRMPSPS----SGSNSGNLYYSFNIGPAHYIMLNSYMDFNHSDPQYMWLEEDLRKVDRTVTPWVVCNMHAPWYNSDVHHHDEYEETAMRASMEDLLHQY
||.||. . |.||. .|||. ...|.|.|.|. |..... || ||||||.||.|..|||... .|.|.|.|. ...|. |. .|.|..||||..|
rfsmpgseegesnssesgsnsysfetesvhfivlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllyky
RVDFVFSGHVHAY
.|| |..||.|.|
gVDlvlaGHeHsY
|
|||||||||
| ACP5 | 141-343 | 8.1e-08 | 24.2 | In-house | 3-197 (198) | alignment | |||
Range on Protein: 141-343
Range on HMM: 3-197/198.0
MIGDLGQTTDS-----ISTLDHIRADFEAHITVLVGDLSYADSAEQNEPTRnctqkRWDSWGQIVEPYFAYQPLMVLPGNHEVEQVgplPATQEQFLAYQ
..|| |.. . ... . .. .... . .|| | | .. . .| .|. .|.. | .|. |||.... . | . .
vvGDwGrkgeynqsavakqmgkvaekldidfvlslGDnfyddGvtsvddpr.....fkesfekiytakslqvpWyvvlGNHDyrgn...vsaqieyakrs
SRFRMPSPSSGSNSGNLYYSFNIGPAHYIMLNSYMDfNHSDPQYMWLEEDLRKVDRTVTPWVVCNMHAPWYNSDVHHHdeyeETAMRASMEDLLHQYRVD
. |.||. . .. ... . . . ..... .... . ..|.. ... . . |.. | | | |.. .. . ... ||..|.||
kdsrfpslryslskkevvtelftekkdeksdqreva.erekyaeeqlkwlekalakstadwkiVvGHhpvySigehgd....tkelverllpllkkykvd
FVFSGHVH
. ..|| |
aYlnGHdH
|
|||||||||
| subfamily_ACP5_pd | Subfamily ACP5 | 142-346 | 2.5e-59 | 192.4 | In-house | 2-189 (189) | alignment | ||
Range on Protein: 142-346
Range on HMM: 2-189/189.0
IGDLGQ-TTDSISTLDHIRADFEAHITVLVGDLSYADSAeqneptrnCTQKRWDSWGQIVEPYFAYQPLMVLPGNHEVEQvgplpatqeQFLAYQSRFRM
.||||. ...|..|| . ... |..... ||||.||..| ... ||.. ...||. .. |.||..||||... .| ||..||.|
fgDlgvseaaslatllkeeeaneldliihvGDlaYalka........kneavwdefmnlieplaskvPymvsiGnhesds.........nfsaykkrfsm
PspssgsnS--GnlYYSFNIGPAHYIMLNSYMDFNHSDPQYMWLEEDLRKV-DRTVTPWVVCNMHAPWYNSDVHHHDE-YEETAMRA----SMEDLLHQY
| | .|||..||.|.|.|....||.....|| |||.||... .|. |||.....| |.| |. ...| .|||..|. |.||||..|
p.......skne..wYsfdygpvhfislstevdfslgseqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllyky
RVDFVFSGHVHAYE
.||...||| |.||
kvdlalsgHeHsYe
|
|||||||||
| subfamily_PAPL_pd | Subfamily PAPL | 266-344 | 3.7e-06 | 18.3 | In-house | 140-211 (212) | alignment | ||
Range on Protein: 266-344
Range on HMM: 140-211/212.0
LNSYMDFNHSDPQYMWLEEDLRKvdrTVTPWVVCNMHAPWYNSDVHHhdeyEETAMRASMEDLLHQYRVDFVFSGHVHA
|. .| . . |..||||.|.. . ... | | . | . .. ... ||..|.|. .||| |
legpvdvslaeeqwawleeeLka...seadylivaGhypvwsvaehG....ptkiLvkrLkPlLekynvtaylsGhDhn
|
|||||||||
| Metallophos_C | Iron/zinc purple acid phosphatase-like protein C | 360-423 | 1.8e-18 | 58.0 | Pfam-A | 2-61 (62) | alignment | ||
Range on Protein: 360-423
Range on HMM: 2-61/62.0
GTTYINIGDGGNREGPaeGYFPQPEWSAYREPVFGHGRLALFNATHAHFTWHKNVDSEpvVSDD
....| .|..||.. . |||||||.|| .|..|| .|.||.|...... | . | |.
ApvhIvvGaAGnglsk..fskpqpewsafresdyGysrltvvNrthLhwefvrsddgq..vlDs
|
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